CD48 antibody | MEM-102
Mouse anti Human CD48
- Product Type
- Monoclonal Antibody
- Clone
- MEM-102
- Isotype
- IgG1
- Specificity
- CD48
Mouse anti Human CD48 antibody, clone MEM-102 recognizes human CD48, also known as B-lymphocyte activation marker BLAST-1, BCM1 surface antigen, Leukocyte antigen MEM-102, SLAM family member 2 or Signaling lymphocytic activation molecule 2. CD 48, as a mature molecule is a 193 amino acid, ~45 kDa cell membrane glycoprotein containing 2 Ig-like domains. CD48 acts as a counter-receptor for CD2 (Kato et al. 1992) and is involved in immune regulation and tolerance (McArdel et al. 2016) Mouse anti Human CD48 antibody, clone MEM-102 is useful for the visualisation of CD48 expressing cells by immunofluorescence (Enose-Akahata et al. 2009) and flow cytometry and may be used to differentiate haemapoietic tumors, sarcomas and melanomas. |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Rhesus Monkey - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- MCA1053GT: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- MCA1053G: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% sodium azide (NaN3)
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Flow Cytometry | |||
Immunofluorescence | |||
Immunohistology - Frozen | 1/50 | 1/100 | |
Immunohistology - Paraffin | |||
Western Blotting 1 |
- 1This product recognizes CD48 under non-reducing conditions.
- Flow Cytometry
- Use 10μl of the suggested working dilution to label 106 cells in 100μl
- Histology Positive Control Tissue
- Tonsil
Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
---|---|---|---|---|---|---|---|
Mouse IgG1 Negative Control | MCA928 | F | 100 Tests | Log in | |||
List Price | Your Price | ||||||
Log in | |||||||
Description | Mouse IgG1 Negative Control |
Source Reference
-
Bazil, V. et al. (1989) Monoclonal antibodies against human leucocyte antigens. III. Antibodies against CD45R, CD6, CD44 and two newly described broadly expressed glycoproteins MEM-53 and MEM-102.
Folia Biol (Praha). 35 (5): 289-97.
References for CD48 antibody
-
Korínek, V. et al. (1991) The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1.
Immunogenetics. 33 (2): 108-12. -
Cinek, T. & Horejsí, V. (1992) The nature of large noncovalent complexes containing glycosyl-phosphatidylinositol-anchored membrane glycoproteins and protein tyrosine kinases.
J Immunol. 149 (7): 2262-70. -
Kanuga, N. et al. (2002) Characterization of genetically modified human retinal pigment epithelial cells developed for in vitro and transplantation studies.
Invest Ophthalmol Vis Sci. 43: 546-55. -
Staffler, G. et al. (2003) Selective inhibition of T cell activation via CD147 through novel modulation of lipid rafts.
J Immunol. 171 (4): 1707-14. -
Fukushima, K. et al. (2005) Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production.
J Biol Chem. 280: 18056-62. -
Enose-Akahata, Y. et al. (2009) High expression of CD244 and SAP regulated CD8 T cell responses of patients with HTLV-I associated neurologic disease.
PLoS Pathog. 5: e1000682. -
Larochelle, A. et al. (2011) Human and rhesus macaque hematopoietic stem cells cannot be purified based only on SLAM family markers.
Blood. 117:1550-4. -
Peterson, L.A. et al. (2019) Individual Differences in the Response of Human β-Lymphoblastoid Cells to the Cytotoxic, Mutagenic, and DNA-Damaging Effects of a DNA Methylating Agent, N-Methylnitrosourethane.
Chem Res Toxicol. 32 (11): 2214-26.
View The Latest Product References
- Synonyms
- BLAST-1
- RRID
- AB_323736
- UniProt
- P09326
- Entrez Gene
- CD48
- GO Terms
- GO:0005515 protein binding
- GO:0006952 defense response
- GO:0007596 blood coagulation
- GO:0005887 integral to plasma membrane
- GO:0045121 membrane raft
- GO:0050900 leukocyte migration
MCA1053GT
1707MCA1053G
1608 1707If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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