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Recombinant DENV NS1 proteins, antibodies & inactivated pathogen
Blog: Four virus serotypes...One Dengue vaccine
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Dengue, according to the W.H.O., is the most rapidly spreading mosquito borne virus in the world. Dengue virus (DENV) is a member of the Flaviviridae family and infection is characterized, in its severe forms, by fever and shock.
The virus has four strains (also called serotypes), which are referred to as DENV-1, DENV-2, DENV-3, and DENV-4. Once cells are infected, DENV encodes a non-structural protein 1 (NS1), a relatively conserved 45- to 50-KDa glycoprotein. NS1 protein is then secreted as a soluble hexamer from the infected mammalian cells.
Previous studies have indicated that NS1 is an effective marker for serotyping and diagnosis of acute Dengue infection, yet its function is not fully understood.
Our recombinant DENV NS1 proteins are presented in their native folded state complete with post-translational modifications. This allows them to deliver optimal antigenicity and makes them suitable for use in vaccine research and serology-based assays. The recombinant DENV NS1 proteins are available in all 4 serotypes.
Bio-Rad also offers a DENV type 2 inactivated pathogen along with antibodies to the virus itself, plus an antibody to the Saint Louis Encephalitis virus strain (MSI-7) envelope glycoprotein, Clone 6b6c-1. This clone also reacts with other members of Flaviviridae including; Dengue 1 (Hawaii), Dengue 2 (New Guinea C), Dengue 3 (H87) and Dengue 4 (H241).