Dengue Virus

Recombinant DENV NS1 proteins, antibodies & inactivated pathogen

Blog: Four virus serotypes One Dengue Vaccine

Blog: Four virus serotypes...One Dengue vaccine 

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About Dengue Virus

Dengue, according to the W.H.O., is the most rapidly spreading mosquito borne virus in the world. Dengue virus (DENV) is a member of the Flaviviridae family and infection is characterized, in its severe forms, by fever and shock.

The virus has four strains (also called serotypes), which are referred to as DENV-1, DENV-2, DENV-3, and DENV-4. Once cells are infected, DENV encodes a non-structural protein 1 (NS1), a relatively conserved 45- to 50-KDa glycoprotein. NS1 protein is then secreted as a soluble hexamer from the infected mammalian cells.

Previous studies have indicated that NS1 is an effective marker for serotyping and diagnosis of acute Dengue infection, yet its function is not fully understood. 

Bio-Rad offering

Our recombinant DENV NS1 proteins are presented in their native folded state complete with post-translational modifications. This allows them to deliver optimal antigenicity and makes them suitable for use in vaccine research and serology-based assays. The recombinant DENV NS1 proteins are available in all 4 serotypes.

Bio-Rad also offers a DENV type 2 inactivated pathogen along with antibodies to the virus itself, plus an antibody to the Saint Louis Encephalitis virus strain (MSI-7) envelope glycoprotein, Clone 6b6c-1. This clone also reacts with other members of Flaviviridae including; Dengue 1 (Hawaii), Dengue 2 (New Guinea C), Dengue 3 (H87) and Dengue 4 (H241).  


Four Serotypes of Dengue Virus (DENV) Non-Structural Protein 1 (NS1)

Product Code Specificity Format Target Applications
PIP047B DENGUE Virus Type 1 NS1 Antigen Rec. Protein Viral  E
PIP048B DENGUE Virus Type 2 NS1 Antigen Rec. Protein Viral E
PIP049A DENGUE Virus Type 3 NS1 Antigen Rec. Protein Viral E
PIP050B DENGUE Virus Type 4 NS1 Antigen Rec. Protein Viral E

Additional Dengue virus related products

Inactivated Pathogen

Product Code Specificity Format Target Applications
PIP006 DENGUE Virus Type 2 antibody  Inactivated Pathogen Viral  E

Antibodies to Dengue Virus

Product Code Specificity Target Host Isotype Clone Applications
2645-5057 DENGUE Virus antibody: Purified Viral Mouse IgG1 3H5.1 IF
MCA2277 DENGUE Virus antibody: Purified Viral Mouse IgG2a Dengue 1-11(3) E, P*, WB
OBT0745 DENGUE Virus antibody: Purified Viral Mouse IgG2a 5161 E
OBT1676 ST. Louis Encephalitis Virus antibody: Purified  Viral Mouse IgG2a 6b6c-1 E, IF