Adenovirus Antibodies and Antigens

About Adenoviruses

Adenoviruses are non-enveloped, icosahedral viruses that can cause respiratory illness, infantile gastroenteritis, and other mild disorders such as conjunctivitis. Adenoviruses are approximately 70‑90 nm in diameter, containing linear double-stranded DNA. They are very resistant and can withstand adverse pH conditions and treatment with chemical or physical agents.

These features of adenoviruses have made them a useful tool for gene transfection and expression in mammalian cells. Due to their infectivity to both quiescent and proliferating cells, adenoviruses have been used as vectors in vaccination and in gene therapy 1,2. Read a micro-review ‘Adenovirus – a Versatile Immunological Tool’ for more background information on this and how it contributed to the discovery of a new memory T cell, and find out which markers and antibodies are key for researching the anti-viral immune response.

Adenovirus Antibodies

Bio-Rad offers a comprehensive range of mammalian adenovirus antibodies, including serotypes 1, 2, 3, 4, 5, 6, 40, and 41. We also offer the adenovirus serotype 5 antigen and a purified protein preparation of the native virus. Our range of adenovirus antibodies includes a polyclonal antibody (0151-9004) which recognizes many adenovirus proteins. We also provide a selection of monoclonal antibodies which recognize the adenovirus hexon. To facilitate quick and simple product selection, the diagram below shows the adenovirus particle’s main components and related products.

Did you know?

  • There are over 50 immunologically distinct serotypes of Adenovirus, which are categorized into the subgenera A-F based on different morphological, oncogenic, hemagglutinating and DNA sequence properties
  • The virus capsid is composed of three different proteins: 12 fiber attachment proteins associated with 12 penton base proteins and 240 hexon proteins, which form the main capsid component 3

Adenovirus particle

Quick and simple antibody selection against the Adenovirus particle:

Hexon

Monoclonal Antibody Clones:

B025 (AD51)
7C11
1431 (2C4)
1461 (3G0)
8C4
1463
Adenovirus particle diagram
 
Related Products:

Antigens

Type 5 hexon

Purified protein

Native Adenovirus

Poly-Specific

Polyclonal Antibody:

0151-9004

References

  1. Thomas. C. E, et al. (2002). Adenovirus binding to the coxsackievirus and adenovirus receptor or integrins is not required to elicit brain inflammation but is necessary to transduce specific neural cell types.
    J Virol. 76(7):3452-60.
  2. Abad. L.W, et al. (2002). Development of a biosensor-based method for detection and isotyping of antibody responses to adenoviral-based gene therapy vectors.
    Anal Biochem.1;310(1):107-13.
  3. Ebner. K, et al. (2005) Comparative sequence analysis of the hexon gene in the entire spectrum of human adenovirus serotypes: phylogenetic, taxonomic, and clinical implications.
    J Virol. 79(20):12635-42.

View all Adenovirus references

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