CD31 antibody | TLD-3A12
Mouse anti Rat CD31 antibody, clone TLDl-3A12 (MCA1334G) used for the demonstration of vasculature in Rat omentum by immunohistofluorescence.
Image caption:
Angiogenesis and macrophage accumuation in visceral peritoneum. Macrophage accumulation (Ed2 positive staining) in omentum (a) and mesentery (b) and angiogenesis (CD31 positive staining) in omentum (c) and mesentery (d) after 5 weeks of PDF exposure and paricalcitol treatment. Representative examples of the omentum with ED2 in green and CD31 in red of control rat (group I), PDF-exposed rat (group III), and PDF-exposed rat treated with paricalcitol (group IV) (e). All data presented as median and interquartiles. Whiskers indicate the extremes. ∗ p <0.05; ∗∗ p <0.01.
From: Stavenuiter AW, Farhat K, Vila Cuenca M, Schilte MN, Keuning ED, Paauw NJ, terWee PM, Beelen RH, Vervloet MG.
Protective Effects of Paricalcitol on Peritoneal Remodeling during Peritoneal Dialysis.
Biomed Res Int. 2015;2015:468574.
This is from an open access article distributed under the terms of a Creative Commons Attribution License.
Mouse anti Rat CD31 antibody, clone TLD-3A12 (MCA1334G) used for detection of rat endothelial cells by immunofluorescence.
Image caption:
Evaluation of endothelial cell apoptosis with TUNEL staining in frozen sections. Quantification of TUNEL positive cells showed significantly more TUNEL(+) cells/lesion (A) and TUNEL (+) cells/mm2 (B) with treatment of NP-ATPμ-Raf compared to the control group on day 3 and 5 after laser injury. There was a statistically significant reduction of CNV size noted on day 7(C). Double-immunofluorescent staining of frozen sections (x20) obtained at 3, 5 and 7 days after laser photocoagulation for the endothelial cell marker CD31 and TUNEL stain (D). *P<0.01. Data are expressed as the mean ± SE.
From: Salehi-Had H, Roh MI, Giani A, Hisatomi T, Nakao S, et al. (2011)
Utilizing Targeted Gene Therapy with Nanoparticles Binding Alpha v Beta 3 for Imaging and Treating Choroidal Neovascularization.
PLoS ONE 6(4): e18864.
This is from an open access article distributed under the terms of a Creative Commons Attribution License.
Mouse anti Rat CD31 antibody, clone TLD-3A12 (MCA1334G) used for detection of ret endothelial cells by immunohistochemistry of tumor cryostat sections.
Image caption:
Comparison of tumour microvessel fractal dimension and diameter in control and rhEPO-treated rats. (A, B) Examples of CD31-stained microvessels in the tumour core of control and rhEPO-treated animals. Bar, 25 μm. (C) Microvessel fractal dimension in the tumour core and rim in control and rhEPO-treated animals. Columns, mean; bars, s.e.; *P=0.006. (D) Microvessel diameter in the tumour core and rim in control and rhEPO-treated animals. Columns, mean; bars, s.e.; *P<0.001; **P=0.07.
From: Ceelen W, Boterberg T, Smeets P, Van Damme N, Demetter P, Zwaenepoel O, Cesteleyn L, Houtmeyers P, Peeters M, Pattyn P.
Recombinant human erythropoietin alpha modulates the effects of radiotherapy on colorectal cancer microvessels. Br J Cancer. 2007 Mar 12;96(5):692-700.
This is from an open access article distributed under the terms of a Creative Commons Attribution License.
Mouse anti Rat CD31 antibody, clone TLD-3A12 (MCA1334G) used for the detection of mesenteric vasculature in rats by immunofluorescence.
Image caption:
(A) Portal-systemic shunting in common bile duct-ligated (CBDL) rats treated with vehicle or brilliant blue G (BBG, CBDL-vehicle: n = 5; CBDL-BBG: n = 7). Compared with vehicle, BBG significantly improved the severity of shunting. (B) Mesenteric vascular density in sham or CBDL rats treated with vehicle or BBG (sham-vehicle: n = 6; sham-BBG: n = 6; CBDL-vehicle: n = 6; CBDL-BBG: n = 9). Vascular area and length per unit of mesenteric window area were significantly reduced in CBDL rats with BBG treatment. ap<0.05 vs. sham-vehicle group. bp<0.005 vs. sham-BBG group. cp<0.005 vs. CBDL-vehicle group.
From: Tung H-C, Lee F-Y, Wang S-S, Tsai M-H, Lee J-Y, Huo T-I, et al. (2015)
The Beneficial Effects of P2X7 Antagonism in Rats with Bile Duct Ligation-induced Cirrhosis.
PLoS ONE 10(5): e0124654.
This is from an open access article distributed under the terms of a Creative Commons Attribution License.
Mouse anti Rat CD31 antibody, clone TLD-3A12 (MCA1334G) used for the quantitation of vascular channels in venous thrombi by western blotting.
Image caption:
Effects of Temporary Dietary Iron Restriction on Leukocyte Recruitment, Neovascularization, and Plasmin System of Stasis-Induced Venous Thrombi in Rats. (A) Representative images of CD68 staining of the venous thrombi. Scale bars: 100 μm. (B) Quantification of CD68 positive cells in the venous thrombi of the DVT and DVT+IR groups (n = 6 in each group). (C) Representative images of vWF staining of the venous thrombi. Scale bars: 50 μm. Arrows show vascular channels. (D) Quantification of vascular channels in the venous thrombi of the DVT and DVT+IR groups (n = 6 in each group). The number of CD68 positive cells or vascular channels in 10 randomly selected high power fields (HPF) was counted in a blinded manner. (E) CD31 protein expression (top; representative gel blots depicting expression of CD31 and GAPDH, bottom; relative levels of expression) in the venous thrombi of the DVT and DVT+IR groups (n = 5 in each group). (F) Intrathrombotic gene expression of uPA, tPA, PAI-1, and fibrinogen α chain in the DVT and DVT+IR groups (n = 4 in each group). *p <0.05 versus the DVT group.
From: Oboshi M, Naito Y, Sawada H, Hirotani S, Iwasaku T, Okuhara Y, et al. (2015)
Temporary Dietary Iron Restriction Affects the Process of Thrombus Resolution in a Rat Model of Deep Vein Thrombosis.
PLoS ONE 10(5): e0126611.
This is from an open access article distributed under the terms of a Creative Commons Attribution License.
Mouse anti RatCD31 antibody, clone TLD-3A12 (MCA1334G) used for the detection of rat CD31 by immunohistochemistry on paraffin embedded tissue sections.
Image caption:
Effects of the PPAR-δ agonist GW610742 on angiogenesis.Representative images from the sham-operated (Sham), myocardial infarction alone (MI), and MI treated with GW610742 (MI + GW) groups on day 7 (A) and day 14 (B) post-surgery. Images using Masson's trichrome staining (MT) show vessels (arrows) in the heart post-operation. The immunoreactivity and positive cell numbers for CD31 and Ki-67 (arrows) were counted in each group post-operation. Values are represented as the mean ± the standard error of the mean (SEM). *P < 0.05 and vs. **P < 0.01 the corresponding MI group. Scale bars = 100 μm and 50 μm for MT, CD31, and Ki-67 staining, respectively. Sham (n = 3/each day), MI (n = 7/each day), MI + GW (n = 7/each day).
From: Park JR, Ahn JH, Jung MH, Koh J-S, Park Y, Hwang S-J, et al.. (2016)
Effects of Peroxisome Proliferator-Activated Receptor-δ Agonist on Cardiac Healing after Myocardial Infarction.
PLoS ONE 11(2): e0148510.
This is from an open access article distributed under the terms of a Creative Commons Attribution License.
Mouse anti RatCD31 antibody, clone TLD-3A12 (MCA1334G) used for the detection of rat CD31 by immunohistochemistry paraffin embedded tissue sections.
Image caption:
Effects of the PPAR-δ agonist GW610742 on angiogenesis.Effects of GW610742 on cardiac angiogenesis on day 0 and day 3 post MI.
Representative images from the sham-operated (Sham), myocardial infarction alone (MI), and MI treated with GW610742 (MI + GW) groups on day 0 (Figure A) and day 3 (Figure B) post-surgery. Images for CD31 and Ki-67 staining show a few vessels in the heart post-operation. The immunoreactivity and positive cell numbers for CD31 and Ki-67 were counted in each group. Values are represented as the mean ± SEM. Scale bars = 100 μm and 50 μm for CD31 and Ki-67 staining, respectively. Sham (n = 3), MI (n = 7), MI + GW (n = 7).
From: Park JR, Ahn JH, Jung MH, Koh J-S, Park Y, Hwang S-J, et al. (2016)
Effects of Peroxisome Proliferator-Activated Receptor-δ Agonist on Cardiac Healing after Myocardial Infarction.
PLoS ONE 11(2): e0148510.
This is from an open access article distributed under the terms of a Creative Commons Attribution License.
Mouse anti Rat CD31 antibody, clone TLD-3A12 (MCA1334G) used for the demonstration of CD31 expressing cells in rat epicardial tissue sections by immunofluorescence.
Image caption:
Improved donor cell survival by epicardial PM-MSC coating. (b–d). Immunofluorescence demonstrated that the PM-MSC complex (orange; labelled with CM-DiI) covered the surface of LV walls (both peri-infarct and infarct areas) at 1 h (b), Day 3 (c), and Day 28 (d). The majority of surviving MSCs retained on the heart surface. Scale bar = 1 mm (e–g). Immunofluorescence demonstrated that donor cells in the IM-MSC group were found forming isolated cell-clusters (orange; labelled with CM-DiI) at 1 h (e), Day 3 (f), and Day 28 (g). The surviving donor cell numbers in the IM-MSC group appeared to be smaller compared to the PM-MSC group. Scale bar = 1 mm (h–j). Immunolabeling detected a monolayer of epicardial cells (green) on the surface of heart in the Sham group (h). The epicardial cells disappeared by one day after PM-MSC placement (i). There were sprouting vessels (green) from the heart into the PM-MSC complex by Day 3 after placement (j). Scale bar = 50μm.
From: Ichihara Y, Kaneko M, Yamahara K, Koulouroudias M, Sato N, Uppal R, Yamazaki K, Saito S, Suzuki K.
Self-assembling peptide hydrogel enables instant epicardial coating of the heart with mesenchymal stromal cells for the treatment of heart failure.
Biomaterials. 2018 Feb;154:12-23.
This is from an open access article distributed under the terms of the Creative Commons Attribution License.
Mouse anti Rat CD31 antibody, clone TLD-3A12 (MCA1334GA) used for the evaluation of vessel formation in rat myocardium by immunofluorescence.
Image caption:
Myocardial angiogenesis. (A) Immunofluorescence staining for endothelium (CD31, in red), pericytes (NG2, in green), smooth muscle cells (SMA, in cyan) and nuclei (DAPI, in blue) in sections of myocardium injected with phosphate‐buffered saline, control cells (CD8) or ASC expressing uncontrolled heterogeneous levels (ALL) or a specific homogeneous VEGF level (SPEC).
From: Melly L, Cerino G, Frobert A, Cook S, Giraud MN, Carrel T, Tevaearai Stahel HT, Eckstein F, Rondelet B, Marsano A, Banfi A.
Myocardial infarction stabilization by cell-based expression of controlled Vascular Endothelial Growth Factor levels.
J Cell Mol Med. 2018 May;22(5):2580-91.
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.
Mouse anti Rat CD31 antibody, clone TLD-3A12 (MCA1334GA) used for the evaluation of vessel formation in rat myocardium by immunofluorescence.
Image caption:
Cell engraftment. Survival of human ASC was assessed by immunostaining for (HLA)‐Class I (red), while endothelium was detected by CD31 expression (green), and nuclei by DAPI staining (blue) 4 weeks after injection of phosphate‐buffered saline, control cells (CD8) or the two VEGF ‐expressing populations (ALL and SPEC). White arrows indicate single engrafted human cells.
From: Melly L, Cerino G, Frobert A, Cook S, Giraud MN, Carrel T, Tevaearai Stahel HT, Eckstein F, Rondelet B, Marsano A, Banfi A.
Myocardial infarction stabilization by cell-based expression of controlled Vascular Endothelial Growth Factor levels.
J Cell Mol Med. 2018 May;22(5):2580-91.
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.
Fitc conjugated Mouse anti Rat CD31 antibody, clone TLD-3A12 (MCA1334F) used to assess CD31 expression on putitive rat adipose derived stem cells (ADSCs) by flow cytometry.
Image caption:
Identification of ADSCs and assessment of their plating efficiency. A. Flow cytometry analysis showed that surface markers including CD44, CD73 and CD90 were positive. While CD45, CD11b and CD31 were negative.
From: Aminzadeh A, Tekiyeh Maroof N, Mehrabani M, Bahrampour Juybari K, Sharifi AM.
Investigating The Alterations of Oxidative Stress Status, Antioxidant Defense Mechanisms, MAP Kinase and Mitochondrial Apoptotic Pathway in Adipose-Derived Mesenchymal Stem Cells from STZ Diabetic Rats.
Cell J. 2020 Jul;22(Suppl 1):38-48.
doi: 10.22074/cellj.2020.6958.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Mouse anti Rat CD31 antibody, clone TLD-3A12 (MCA1334G) used to demonstrate angiogenesis in rat liver by immunofluorescence.
Image caption:
Effects of glycyrrhizin on intrahepatic angiogenesis.
Intrahepatic angiogenesis over sinusoidal area was evaluated by CD31 staining targeting endothelial cells. Intrahepatic angiogenesis over portal area was investigated by α-SMA staining for vascular smooth muscle cells. The results were consistent. Intrahepatic vessels increased significantly in BDL-vehicle group compared with sham-vehicle group. Glycyrrhizin did not significantly influence the vascular numbers in the liver (n = 6, 6, 6, 6). Scale bar = 200 μm.
From: Pun CK, Huang HC, Chang CC, Chuang CL, Yen CH, Hsu SJ, Lee FY, Hou MC, Huang YH.
Glycyrrhizin Attenuates Portal Hypertension and Collateral Shunting via Inhibition of Extrahepatic Angiogenesis in Cirrhotic Rats.
Int J Mol Sci. 2021 Jul 17;22(14):7662.
doi: 10.3390/ijms22147662.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Mouse anti Rat CD31 antibody, clone TLD-3A12 (MCA1334G) used to label rat mesenteric vasvulature by immunofluorescence.
Image caption:
Effects of the MMP-2/MMP-9 inhibitor SB-3CT on extrahepatic systems.
Mesenteric vascular density was decreased in the SB-3CT-treated group.
From: Huang HC, Ho HL, Chang CC, Chuang CL, Pun CK, Lee FY, Huang YH, Hou MC, Hsu SJ.
Matrix metalloproteinase-9 inhibition or deletion attenuates portal hypertension in rodents.
J Cell Mol Med. 2021 25 (21):10073-87.].
doi: 10.1111/jcmm.16940
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Mouse anti Rat CD31 antibody, clone TLD-3A12 (MCA1334G) used to label CD31 expressing cells in rat liver by immunohistochemistry on formalin fixed, paraffin embedded tissue sections.
Image caption:
The immunohistochemical staining of liver in sham and BDL rats with or without alirocumab treatments. There were many CD31-positive staining cells (green arrow indicating brown cells) and free cholesterol droplet (green arrow indicating light blue cells) in the liver of BDL rats (magnification 200×), indicating the increased intrahepatic angiogenesis and steatosis. In contrast, there are scanty CD31-positive staining cells and free cholesterol droplet in the liver of sham rats. Alirocumab did not reduce the numbers of CD31-staining cells and filipin-staining droplets in BDL and sham rats
From: Huang HC, Hsu SJ, Chang CC, Chuang CL, Hou MC, Lee FY.
Effects of PCSK-9 Inhibition by Alirocumab Treatments on Biliary Cirrhotic Rats.
Int J Mol Sci. 2022 Jul 2;23(13):7378.
doi: 10.3390/ijms23137378.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
FITC conjugated Mouse anti Rat CD31 antibody, clone TLD-3A12 (MCA1334F) used to label rat vasculature endothelial cells by flow cytometry.
Image caption:
Gating strategy for different cell populations from LV tissue and PBLs. (a) Representative gating images of flow cytometry analysis for single-cell populations from WT LV tissue at 72 h after MI using the pan-leukocyte cell surface marker CD45, cTnT for cardiomyocytes (CMs), CD31 for vascular endothelial cells (VECs), α-SMA for smooth muscle cells (SMCs) and fibroblasts, HIS48 for neutrophils, and HIS36 for macrophages.
From: Zhou X, Zhang C, Wu X, Hu X, Zhang Y, Wang X, Zheng L, Gao P, Du J, Zheng W, Shang H, Hu K, Jiang Z, Nie Y, Hu S, Xiao RP, Zhu X, Xiong JW.
Dusp6 deficiency attenuates neutrophil-mediated cardiac damage in the acute inflammatory phase of myocardial infarction.
Nat Commun. 2022 Nov 5;13(1):6672.
doi: 10.1038/s41467-022-33631-z.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Biotinylated Mouse anti Rat CD31 antibody, clone TLD-3A12 (MCA1334B) used to label mesenteric vaculature by immunofluorescence.
Image caption:
Effects of chronic alcohol administration on the mesentery
(A) Mesenteric angiogenesis was evaluated by the vascular density of mesenteric windows. In the cirrhotic rats, the mesenteric vascular density was markedly higher than in the sham rats. The vascular area per unit area of mesenteric window was significant higher in the chronic alcohol-treated BDL group (n = 6, 6, 5, 6; Sham-vehicle; Sham-alcohol; BV, BDL-vehicle; BA, BDL-alcohol).Insert image caption
From: Pun CK, Huang HC, Chang CC, Hsu SJ, Chuang CL, Huang YH, Hou MC, Lee FY.
Low-dose alcohol exacerbates hyperdynamic circulation and shunting in non-alcoholic cirrhotic rats.
Biosci Rep. 2024 Jul 31;44(7):BSR20240354.
doi: 10.1042/BSR20240354.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Mouse anti Rat CD31
- Product Type
- Monoclonal Antibody
- Clone
- TLD-3A12
- Isotype
- IgG1
- Specificity
- CD31
Antibody Quality and Performance Guarantee
| Mouse anti Rat CD31 antibody, clone TLD-3A12 recognizes rat PECAM-1 (CD31), a 661 amino acid type 1 transmembrane protein expressed primarily on endothelial cells, platelets and leucocytes. Clone TLD-3A12 has been shown to partially block the proliferative response of antigen-specific CD4+ T cells to antigen-presenting cells and relevant antigen (Stevenson, K.S. et al.2009). Mouse anti Rat CD31 antibody, clone TLD-3A12 is suitable for use in IHC on formalin-fixed paraffin-embedded sections pre-treated with 0.2M boric acid, pH7.0. (Wilson et al. 2007). Mouse anti Rat CD31, clone TLD-3A12 has been shown to be cross-reactive with endothelial cells derived from rhesus macaque (Maclean et al. 2001) |
- Target Species
- Rat
- Species Cross-Reactivity
-
Target Species Cross Reactivity Rhesus Monkey Pig - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% sodium azide (NaN3)
- Carrier Free
- Yes
- Immunogen
- Activated, Lewis rat derived microglial cells.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunized BALB/c mouse were fused with cells of the mouse SP2 myeloma cell line.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
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| Flow Cytometry | |
1/10 | 1/100 |
| Immunofluorescence | |
||
| Immunohistology - Frozen | |
1/10 | 1/100 |
| Western Blotting | |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10μl of the suggested working dilution to label 106 cells in 100μl
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse IgG1 Negative Control | MCA1209 | F | 0.1 mg |
|
Log in | ||
| List Price | Your Price | ||||||
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Log in | ||||||
| Description | Mouse IgG1 Negative Control | ||||||
Source Reference
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Glia. 7 (1): 34-40.
References for CD31 antibody
-
Williams, K.C. et al. (1996) PECAM-1 (CD31) expression in the central nervous system and its role in experimental allergic encephalomyelitis in the rat.
J Neurosci Res. 45 (6): 747-57. -
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MacLean, A.G. et al. (2001) Rhesus macaque brain microvessel endothelial cells behave in a manner phenotypically distinct from umbilical vein endothelial cells.
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Arthritis Rheum. 48: 2173-7. -
Wilson, E. et al. (2007) An evaluation of the immunohistochemistry benefits of boric acid antigen retrieval on rat decalcified joint tissues.
J Immunol Methods. 322: 137-42.
View The Latest Product References
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Biomed Res Int. 2015: 468574. -
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PLoS One. 10 (5): e0124654. -
Park; J.R. et al. (2016) Effects of Peroxisome Proliferator-Activated Receptor-δ Agonist on Cardiac Healing after Myocardial Infarction.
PLoS One. 11 (2): e0148510. -
Lux, M. et al. (2016) In vitro maturation of large-scale cardiac patches based on a perfusable starter matrix by cyclic mechanical stimulation.
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Biomaterials. 154: 12-23. -
Melly, L. et al. (2018) Myocardial infarction stabilization by cell-based expression of controlled Vascular Endothelial Growth Factor levels.
J Cell Mol Med. 22 (5): 2580-91. -
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- Synonyms
- PECAM-1
- RRID
- AB_322925
- UniProt
- Q3SWT0
- Entrez Gene
- Pecam1
- GO Terms
- GO:0005515 protein binding
- GO:0002687 positive regulation of leukocyte migration
- GO:0007155 cell adhesion
- GO:0016021 integral to membrane
- GO:0006928 cellular component movement
- GO:0009986 cell surface
- GO:0030054 cell junction
- GO:0034097 response to cytokine stimulus
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