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CD68 antibody | FA-11

Product Code Applications Pack Size List Price Your Price Qty
MCA1957T
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SDS Safety Datasheet SDS
C F * IF IP P * WB * 25 µg loader
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MCA1957GA
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SDS Safety Datasheet SDS
C F * IF IP P * WB * 0.1 mg loader
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loader
MCA1957
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C F * IF IP P * WB * 0.25 mg loader
List Price Your Price
loader

Rat anti Mouse CD68 antibody, clone FA-11 recognizes mouse macrosialin, a heavily glycosylated transmembrane protein and murine homolog of human CD68, classified as a unique scavenger receptor (ScR) family member, due to the presence of a lysosome associated membrane protein (LAMP)-like domain.

CD68 is considered a pan macrophage marker, predominantly expressed on the intracellular lysosomes of tissue macrophages/monocytes, including Kupffer cells, microglia, histiocytes and osteoclasts, and is expressed to a lesser extent by dendritic cells and peripheral blood granulocytes.

CD68 is expressed by many tumor types including some B cell lymphomas, blastic NK lymphomas, melanomas, granulocytic (myeloid) sarcomas, hairy cell leukemias, and renal, urinary and pancreatic tumors, and can be used to demonstrate the presence/localization of macrophages.

Rat anti mouse CD68 antibody, clone FA-11, has been used in many mouse models for the identification of CD68 in immunohistochemical assays, using both frozen and paraffin-embedded tissues (Masaki et al. 2003) and (Devey et al. 2009).

Rat anti mouse CD68 antibody, clone FA-11 can be used in flow cytometry to detect intracellular CD68, following permeabilization, and can detect surface macrosialin at low levels in resident mouse peritoneal macrophages which can be enhanced with thioglycollate stimulation.
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Our CD68 (FA-11) Antibody has been referenced in >648 publications*


*Based on June 2020 data from CiteAb's antibody search engine.

Target Species
Mouse
Product Form
Purified IgG - liquid
Preparation
MCA1957T, MCA1957: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
MCA1957GA: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
Buffer Solution
MCA1957T: Phosphate buffered saline.
MCA1957GA, MCA1957: Phosphate buffered saline
Preservative Stabilisers
0.09% sodium azide (NaN3)
Carrier Free
Yes
Immunogen
Purified Concanavalin A acceptor glycoprotein from P815 cell line.
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Regulatory
MCA1957T: For research purposes only.
MCA1957GA, MCA1957: For research purposes only
Guarantee
MCA1957T: 12 months from date of despatch.
MCA1957GA, MCA1957: 12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry 1 1/50 1/100
Immunofluorescence
Immunohistology - Frozen
Immunohistology - Paraffin 2
Immunoprecipitation
Western Blotting 3
  1. 1 Membrane permeabilization is required for this application. Bio-Rad recommends the use of Leucoperm (Product Code BUF09) for this purpose.
  2. 2This product may require antigen retrieval using heat treatment prior to staining of paraffin sections. Either sodium citrate buffer or Tris/EDTA buffer may be used for this purpose (Martin-Manso et al. 2008). Staining has also been achieved without antigen retrieval (Lu et al. 2010).
  3. 3 Non-reducing conditions recommended.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 10μl of the suggested working dilution to label 106 cells in 100μl

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Description Rabbit F(ab')2 anti Rat IgG:HRP
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Description Goat F(ab')2 anti Rat IgG:FITC (Mouse Adsorbed)
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Description Goat anti Rat IgG:DyLight®550 (Mouse Adsorbed)
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Description Goat anti Rat IgG:DyLight®650 (Mouse Adsorbed)
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Description Goat anti Rat IgG:Dylight®800 (Mouse Adsorbed)
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Description Goat anti Rat IgG:HRP (Mouse Adsorbed)
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Description Goat F(ab')2 anti Rat IgG:RPE (Mouse Adsorbed)

Description Product Code Applications Pack Size List Price Your Price Quantity
Rat IgG2a Negative Control MCA1212 E F 1 ml loader
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Description Rat IgG2a Negative Control

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Antigen Retrieval Buffer, pH8.0 BUF025A P 500 ml
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Description Antigen Retrieval Buffer, pH8.0
Leucoperm BUF09 F 50 Tests
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Description Leucoperm

Source Reference

  1. Smith, M. and Koch, G. (1987) Differential expression of murine macrophage surface glycoprotein antigens in intracellular membranes.
    J Cell Sci. 87:113-9.

References for CD68 antibody

  1. Rabinowitz, S.S. & Gordon, S. (1991) Macrosialin, a macrophage-restricted membrane sialoprotein differentially glycosylated in response to inflammatory stimuli.
    J Exp Med. 174 (4): 827-36.
  2. Ramprasad, M.P. et al. (1996) Cell surface expression of mouse macrosialin and human CD68 and their role as macrophage receptors for oxidized low density lipoprotein.
    Proc Natl Acad Sci U S A. 93 (25): 14833-8.
  3. da Silva, R.P. & Gordon, S. (1999) Phagocytosis stimulates alternative glycosylation of macrosialin (mouse CD68), a macrophage-specific endosomal protein.
    Biochem J. 338 ( Pt 3): 687-94.
  4. de Beer, M.C. et al. (2003) Lack of a direct role for macrosialin in oxidized LDL metabolism.
    J Lipid Res. 44: 674-85.
  5. Masaki, T. et al. (2003) Heterogeneity of antigen expression explains controversy over glomerular macrophage accumulation in mouse glomerulonephritis.
    Nephrol. Dial. Transplant 18:178-81.
  6. Schleicher, U. et al. (2005) Minute numbers of contaminant CD8+ T cells or CD11b+CD11c+ NK cells are the source of IFN-{gamma} in IL-12/IL-18-stimulated mouse macrophage populations.
    Blood 105: 1319-1328.
  7. Echeverry, A. et al. (2007) Murine neonates are highly resistant to Yersinia enterocolitica following orogastric exposure.
    Infect Immun. 75: 2234-43.
  8. Baran, C.P. et al. (2007) Important roles for macrophage colony-stimulating factor, CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis.
    Am J Respir Crit Care Med. 176: 78-89.
  9. View The Latest Product References
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  14. Plüddemann, A. et al. (2009) The macrophage scavenger receptor A is host-protective in experimental meningococcal septicaemia.
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  15. Bacci, M. et al. (2009) Macrophages are alternatively activated in patients with endometriosis and required for growth and vascularization of lesions in a mouse model of disease
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    J Exp Med. 208: 455-67.
  31. Rahaman, S.O. et al. (2011) Vav family Rho guanine nucleotide exchange factors regulate CD36-mediated macrophage foam cell formation.
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    J Lipid Res. 52: 1542-50.
  36. Giannattasio, G. et al. (2011) The purinergic g protein-coupled receptor 6 inhibits effector T cell activation in allergic pulmonary inflammation.
    J Immunol. 187: 1486-95.
  37. Papadeas, S.T. et al. (2011) Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo.
    Proc Natl Acad Sci U S A. 108: 17803-8.
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    J Neurosci 32: 3652-64
  39. Kyaw, T. et al. (2012) Depletion of B2 but not B1a B cells in BAFF receptor-deficient ApoE mice attenuates atherosclerosis by potently ameliorating arterial inflammation.
    PLoS One. 7: e29371.
  40. Akbarshahi, H. et al. (2012) Enrichment of Murine CD68(+)CCR2(+) and CD68(+)CD206(+) Lung Macrophages in Acute Pancreatitis-Associated Acute Lung Injury.
    PLoS One. 7: e42654.
  41. Douglas, G. et al. (2012) Endothelial-Specific Nox2 Overexpression Increases Vascular Superoxide and Macrophage Recruitment in ApoE-/- mice.
    Cardiovasc Res. 94: 20-9.
  42. Rojanathammanee, L. et al. (2013) Pomegranate polyphenols and extract inhibit nuclear factor of activated T-cell activity and microglial activation in vitro and in a transgenic mouse model of Alzheimer disease.
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    J Am Heart Assoc. 2 (5): e000411.
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  46. Nishikawa, K. et al. (2015) Resveratrol increases CD68⁺ Kupffer cells colocalized with adipose differentiation-related protein and ameliorates high-fat-diet-induced fatty liver in mice.
    Mol Nutr Food Res. 59 (6): 1155-70.
  47. Nishiyama, K. et al. (2015) Mouse CD11b+ Kupffer Cells Recruited from Bone Marrow Accelerate Liver Regeneration after Partial Hepatectomy.
    PLoS One. 10 (9): e0136774.
  48. Hamour, S. et al. (2015) Local IL-17 Production Exerts a Protective Role in Murine Experimental Glomerulonephritis.
    PLoS One. 10 (8): e0136238.
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    Neurobiol Aging. 42: 50-60.
  50. Xiang, X. et al. (2016) TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance.
    EMBO Mol Med. 8 (9): 992-1004.
  51. Wang L et al. (2016) Bone Fracture Pre-Ischemic Stroke Exacerbates Ischemic Cerebral Injury in Mice.
    PLoS One. 11 (4): e0153835.
  52. Nguyen, T.V. et al. (2016) Multiplex immunoassay characterization and species comparison of inflammation in acute and non-acute ischemic infarcts in human and mouse brain tissue.
    Acta Neuropathol Commun. 4 (1): 100.
  53. Giraldo, J.A. et al. (2017) The impact of cell surface PEGylation and short-course immunotherapy on islet graft survival in an allogeneic murine model.
    Acta Biomater. 49: 272-283.
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    J Neuroinflammation. 13 (1): 287.
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    J Neurosci. 37 (14): 3926-39.
  56. Nakaya, M. et al. (2017) Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction.
    J Clin Invest. 127 (1): 383-401.
  57. Maeda, K. et al. (2017) Inhibition of H3K9 methyltransferase G9a ameliorates methylglyoxal-induced peritoneal fibrosis.
    PLoS One. 12 (3): e0173706.
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    PLoS Biol. 15 (8): e2001993.
  59. Koh, A.J. et al. (2017) The skeletal impact of the chemotherapeutic agent etoposide.
    Osteoporos Int. 28 (8): 2321-33.
  60. Menzies, R.I. et al. (2017) Hyperglycemia-induced Renal P2X7 Receptor Activation Enhances Diabetes-related Injury.
    EBioMedicine. 19: 73-83.
  61. Takane, K. et al. (2017) Detrimental Effects of Centrally Administered Angiotensin II are Enhanced in a Mouse Model of Alzheimer Disease Independently of Blood Pressure.
    J Am Heart Assoc. 6 (4): e004897.
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    J Vasc Surg. 67 (2): 573-584.e2.
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    Oxidative Med Cellular Longev. 2017: 1-18.
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    J Clin Invest. 127 (8): 2904-15.
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    Am J Pathol. 187 (4): 740-751.
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    J Mol Med (Berl). 96 (12): 1359-73.
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    Diabetes. 67 (9): 1880-91.
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    Glia. 66 (12): 2632-2644.
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    Glia. 66 (12): 2589-603.
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    BMC Nephrol. 19 (1): 61.
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    PLoS One. 13 (3): e0193737.
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    Am J Physiol Cell Physiol. 317 (4): C776-C787.
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    Am J Transl Res. 11 (7): 4063-76.
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    Alcohol Clin Exp Res. 43 (7): 1403-13.
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    Cardiovasc Res. 116 (3): 554-565.
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    Brain Behav Immun. 87: 243-55.
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  87. Götze, A.M. et al. (2020) IL10 Alters Peri-Collateral Macrophage Polarization and Hind-Limb Reperfusion in Mice after Femoral Artery Ligation.
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  98. Grundmann, S.M. et al. (2020) High-phosphorus diets reduce aortic lesions and cardiomyocyte size and modify lipid metabolism in Ldl receptor knockout mice.
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    J Neuroinflammation. 17 (1): 365.
  101. Huang, J. et al. (2020) Bone Fracture Enhanced Blood-Brain Barrier Breakdown in the Hippocampus and White Matter Damage of Stroke Mice.
    Int J Mol Sci.21(22):8481.
  102. Lowe, P.P. et al. (2020) Chronic alcohol-induced neuroinflammation involves CCR2/5-dependent peripheral macrophage infiltration and microglia alterations.
    J Neuroinflammation. 17 (1): 296.
  103. Stroobants, S. et al. (2020) Aged Tmem106b knockout mice display gait deficits in coincidence with Purkinje cell loss and only limited signs of non-motor dysfunction.
    Brain Pathol. : e12903.
  104. Alberti, S. et al. (2020) The antiplatelet agent revacept prevents the increase of systemic thromboxane A2 biosynthesis and neointima hyperplasia.
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    J Neuroinflammation. 17 (1): 159.
  106. Ribeiro, P.C. et al. (2020) Therapeutic potential of human induced pluripotent stem cells and renal progenitor cells in experimental chronic kidney disease.
    Stem Cell Res Ther. 11 (1): 530.
  107. Miró, L. et al. (2020) Dietary Supplementation with Spray-Dried Porcine Plasma Attenuates Colon Inflammation in a Genetic Mouse Model of Inflammatory Bowel Disease.
    Int J Mol Sci. 21(18): 6760.
  108. Zhou, F. et al. (2020) β-Carotene conversion to vitamin A delays atherosclerosis progression by decreasing hepatic lipid secretion in mice.
    J Lipid Res. 61 (11): 1491-1503.
  109. Nelvagal, H.R. et al. (2020) Comparative proteomic profiling reveals mechanisms for early spinal cord vulnerability in CLN1 disease.
    Sci Rep. 10 (1): 15157.
  110. Grubišić, V. et al. (2020) Enteric Glia Modulate Macrophage Phenotype and Visceral Sensitivity following Inflammation.
    Cell Rep. 32 (10): 108100.
  111. Riedl, K.A. et al. (2020) Wall shear stress analysis using 17.6 Tesla MRI: A longitudinal study in ApoE-/- mice with histological analysis.
    PLoS One. 15 (8): e0238112.
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Synonyms
Macrosialin
RRID
AB_322219
UniProt
P31996
Entrez Gene
Cd68
GO Terms
GO:0005886 plasma membrane
GO:0016021 integral to membrane
GO:0005765 lysosomal membrane
GO:0010008 endosome membrane

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