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CD68 antibody | FA-11

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SDS Safety Datasheet SDS
C F * IF IP P * WB * 25 µg loader
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Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C F * IF IP P * WB * 0.1 mg loader
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Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C F * IF IP P * WB * 0.25 mg loader
List Price Your Price

Rat anti Mouse CD68 antibody, clone FA-11 recognizes mouse macrosialin, a heavily glycosylated transmembrane protein and murine homolog of human CD68, classified as a unique scavenger receptor (ScR) family member, due to the presence of a lysosome associated membrane protein (LAMP)-like domain.

CD68 is considered a pan macrophage marker, predominantly expressed on the intracellular lysosomes of tissue macrophages/monocytes, including Kupffer cells, microglia, histiocytes and osteoclasts, and is expressed to a lesser extent by dendritic cells and peripheral blood granulocytes.

CD68 is expressed by many tumor types including some B cell lymphomas, blastic NK lymphomas, melanomas, granulocytic (myeloid) sarcomas, hairy cell leukemias, and renal, urinary and pancreatic tumors, and can be used to demonstrate the presence/localization of macrophages.

Rat anti mouse CD68 antibody, clone FA-11, has been used in many mouse models for the identification of CD68 in immunohistochemical assays, using both frozen and paraffin-embedded tissues (Masaki et al. 2003) and (Devey et al. 2009).

Rat anti mouse CD68 antibody, clone FA-11 can be used in flow cytometry to detect intracellular CD68, following permeabilization, and can detect surface macrosialin at low levels in resident mouse peritoneal macrophages which can be enhanced with thioglycollate stimulation.
CiteAb logo - trusted, tested, published

Our CD68 (FA-11) Antibody has been referenced in >648 publications*

*Based on June 2020 data from CiteAb's antibody search engine.

Target Species
Product Form
Purified IgG - liquid
MCA1957T, MCA1957: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
MCA1957GA: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
Buffer Solution
MCA1957T: Phosphate buffered saline.
MCA1957GA, MCA1957: Phosphate buffered saline
Preservative Stabilisers
0.09% sodium azide (NaN3)
Carrier Free
Purified Concanavalin A acceptor glycoprotein from P815 cell line.
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
MCA1957T: For research purposes only.
MCA1957GA, MCA1957: For research purposes only
MCA1957T: 12 months from date of despatch.
MCA1957GA, MCA1957: 12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry 1 1/50 1/100
Immunohistology - Frozen
Immunohistology - Paraffin 2
Western Blotting 3
  1. 1 Membrane permeabilization is required for this application. Bio-Rad recommends the use of Leucoperm (Product Code BUF09) for this purpose.
  2. 2This product may require antigen retrieval using heat treatment prior to staining of paraffin sections. Either sodium citrate buffer or Tris/EDTA buffer may be used for this purpose (Martin-Manso et al. 2008). Staining has also been achieved without antigen retrieval (Lu et al. 2010).
  3. 3 Non-reducing conditions recommended.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 10μl of the suggested working dilution to label 106 cells in 100μl

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Description Leucoperm

Source Reference

  1. Smith, M. and Koch, G. (1987) Differential expression of murine macrophage surface glycoprotein antigens in intracellular membranes.
    J Cell Sci. 87:113-9.

References for CD68 antibody

  1. Rabinowitz, S.S. & Gordon, S. (1991) Macrosialin, a macrophage-restricted membrane sialoprotein differentially glycosylated in response to inflammatory stimuli.
    J Exp Med. 174 (4): 827-36.
  2. Ramprasad, M.P. et al. (1996) Cell surface expression of mouse macrosialin and human CD68 and their role as macrophage receptors for oxidized low density lipoprotein.
    Proc Natl Acad Sci U S A. 93 (25): 14833-8.
  3. da Silva, R.P. & Gordon, S. (1999) Phagocytosis stimulates alternative glycosylation of macrosialin (mouse CD68), a macrophage-specific endosomal protein.
    Biochem J. 338 ( Pt 3): 687-94.
  4. de Beer, M.C. et al. (2003) Lack of a direct role for macrosialin in oxidized LDL metabolism.
    J Lipid Res. 44: 674-85.
  5. Masaki, T. et al. (2003) Heterogeneity of antigen expression explains controversy over glomerular macrophage accumulation in mouse glomerulonephritis.
    Nephrol. Dial. Transplant 18:178-81.
  6. Schleicher, U. et al. (2005) Minute numbers of contaminant CD8+ T cells or CD11b+CD11c+ NK cells are the source of IFN-{gamma} in IL-12/IL-18-stimulated mouse macrophage populations.
    Blood 105: 1319-1328.
  7. Echeverry, A. et al. (2007) Murine neonates are highly resistant to Yersinia enterocolitica following orogastric exposure.
    Infect Immun. 75: 2234-43.
  8. Baran, C.P. et al. (2007) Important roles for macrophage colony-stimulating factor, CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis.
    Am J Respir Crit Care Med. 176: 78-89.
  9. View The Latest Product References
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    J Lipid Res. 61 (11): 1491-1503.
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    Sci Rep. 10 (1): 15157.
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    Cell Rep. 32 (10): 108100.
  111. Riedl, K.A. et al. (2020) Wall shear stress analysis using 17.6 Tesla MRI: A longitudinal study in ApoE-/- mice with histological analysis.
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  112. Gómez-Almería, M. et al. (2021) BiP Heterozigosity Aggravates Pathological Deterioration in Experimental Amyotrophic Lateral Sclerosis.
    Int J Mol Sci. 22(22):12533.
  113. Freeley, S.J. et al. (2022) The lectin pathway does not contribute to glomerular injury in the nephrotoxic nephritis model.
    Nephrology (Carlton). 27 (2): 208-14.
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Flow Cytometry


Immunohistology - Frozen

Immunohistology - Paraffin

Western Blotting

Entrez Gene
GO Terms
GO:0005886 plasma membrane
GO:0016021 integral to membrane
GO:0005765 lysosomal membrane
GO:0010008 endosome membrane

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