Dectin-1 antibody | BD6
Mouse anti Human Dectin-1
- Product Type
- Monoclonal Antibody
- Clone
- BD6
- Isotype
- IgG2b
- Specificity
- Dectin-1
Antibody Quality and Performance Guarantee
| Mouse anti Human Dectin-1 antibody, clone BD6 recognizes human Dectin-1, also known as beta-glucan receptor (βGR) or CD369. Dectin-1 is a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans, glucose polymers that form cell-wall components or exopolymers of yeasts, fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial, yeast, viral and protozoan infections, as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells. Human Dectin-1 has two major (βGR-A and βGR-B) and several minor isoforms. βGR-A and βGR-B differs by the presence and absence, respectively, of a stalk region. Mouse anti Human Dectin-1 antibody, clone BD6 recognizes βGR-A only. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- MCA4662: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- MCA4662GA: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Carrier Free
- Yes
- Immunogen
- NIH3T3 cells expressing full length Beta-glucan receptor.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- Fusion Partners
- Spleen cells from immunized C57BL/6 were fused with cells of the murine SP2 myeloma cell line.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry |  |
1/25 | 1/200 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse IgG2b Negative Control | MCA691 | F | 100 Tests |
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| Description | Mouse IgG2b Negative Control | ||||||
Source Reference
-
Willment, J.A. et al. (2005) The human beta-glucan receptor is widely expressed and functionally equivalent to murine Dectin-1 on primary cells.
Eur J Immunol. 35 (5): 1539-47.
References for Dectin-1 antibody
-
Plantinga, T.S. et al. (2009) Early stop polymorphism in human DECTIN-1 is associated with increased candida colonization in hematopoietic stem cell transplant recipients.
Clin Infect Dis. 49 (5): 724-32. -
Hoeksema, M.A. et al. (2014) Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions.
EMBO Mol Med. 6 (9): 1124-32.
- Synonyms
- Beta Glucan Receptor
- CD369
- RRID
- AB_1628802
- UniProt
- Q9BXN2
- Entrez Gene
- CLEC7A
MCA4662
148808
168961
MCA4662GA
151269
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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