CD79a antibody | HM57

Mouse anti Human CD79a

Product Type
Monoclonal Antibody
Clone
HM57
Isotype
IgG1
Specificity
CD79a

Product Code Applications Pack Size List Price Your Price Qty
MCA2538T
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C F * P * WB 25 µg loader
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loader
MCA2538H
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SDS Safety Datasheet SDS
C F * P * WB 1 ml loader
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loader
MCA2538
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SDS Safety Datasheet SDS
C F * P * WB 0.2 mg loader
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loader
MCA2538GA
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C F * P * 0.1 mg loader
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loader
Search for Batch Specific Datasheets

Mouse anti Human CD79a antibody, clone HM57 recognizes an epitope within the cytoplasmic domain of CD79a. CD79a, also known as mb-1, is a 45 kDa protein that is expressed by B lymphocytes during differentiation from early pre-B cell stage through to plasma cells.

The CD79a molecule associates with CD79b (B29) to form a heterodimer that is non-covalently linked to surface immunoglobulin, forming the B-cell receptor (BCR) complex. The CD79a/CD79b heterodimers are also necessary for intracellular signaling following antigen-binding to surface immunoglobulin.

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rabbit
Horse
Pig
Monkey
Rat
Bovine
Guinea Pig
Fallow deer
American Bison
Red deer
Ferret
Goat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
Pack Size: 25 µg, 0.2 mg, 0.1 mg
0.09%Sodium Azide (NaN3)
Pack Size: 1 ml
0.09%Sodium Azide (NaN3)
1%Bovine Serum Albumin
Carrier Free
Yes
Immunogen
Synthetic peptide corresponding to 202-216 amino acid sequence of human mb-1
Approx. Protein Concentrations
Pack Size: 25 µg, 0.2 mg, 0.1 mg
IgG concentration 1.0mg/ml
Pack Size: 1 ml
IgG concentration 0.1mg/ml
Fusion Partners
Spleen cells from immunised Balb/c mice were fused with cells of the Sp2/0 myeloma cell line
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry 1 1/10 Pack Size: 25 µg, 1 ml
1/50 Pack Size: 0.2 mg, 0.1 mg
1/50 Pack Size: 25 µg
1/25 Pack Size: 1 ml
1/100 Pack Size: 0.2 mg, 0.1 mg
Immunohistology - Frozen
Immunohistology - Paraffin 2 1/100 1/500
Western Blotting
  1. 1 Membrane permeabilization is required for this application. The use of Leucoperm (Product Code BUF09) is recommended for this purpose.
  2. 2This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
Histology Positive Control Tissue
Human tonsil

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Description Mouse IgG1 Negative Control

References for CD79a antibody

  1. Mason, D.Y. et al. (1991) The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells.
    J Immunol. 147 (11): 2474-82.
  2. Jones, M. et al. (1993) Detection of T and B cells in many animal species using cross-reactive anti-peptide antibodies.
    J Immunol. 150 (12): 5429-35.
  3. Christgau, M. et al. (1998) Characterization of immunocompetent cells in the diseased canine periodontium.
    J Histochem Cytochem. 46: 1443-54.
  4. Spaas, J.H. et al. (2013) Culture and characterisation of equine peripheral blood mesenchymal stromal cells.
    Vet J. 195 (1): 107-13.
  5. Nelson, D.D. et al. (2010) CD8(+)/perforin(+)/WC1(-) gammadelta T cells, not CD8(+) alphabeta T cells, infiltrate vasculitis lesions of American bison (Bison bison) with experimental sheep-associated malignant catarrhal fever.
    Vet Immunol Immunopathol. 136: 284-91.
  6. De Schauwer, C. et al. (2012) In search for cross-reactivity to immunophenotype equine mesenchymal stromal cells by multicolor flow cytometry.
    Cytometry A. 81 (4): 312-23.
  7. Long, H. et al. (2016) Polyostotic Lymphoma in a Ferret (Mustela putorius furo).
    J Comp Pathol. 154 (4): 341-4.
  8. Schinköthe J >et al. (2016) Characterization of tuberculous granulomas in different stages of progression and associated tertiary lymphoid tissue in goats experimentally infected with Mycobacterium avium subsp. hominissuis.
    Comp Immunol Microbiol Infect Dis. 47: 41-51.
  9. View The Latest Product References
  10. Bozkurt, Y.A., et al. (2014) Histological and immunohistological studies of the structure of lymph nodes in Kilis goats.
    Biotech Histochem. 89(6):440-5.
  11. Froment R & Bédard C (2016) Marked hyperphosphatasemia associated with an acute leukemia in a Great Dane.
    Vet Clin Pathol. Aug 18. [Epub ahead of print]
  12. Aresu, L. et al. (2015) Canine indolent and aggressive lymphoma: clinical spectrum with histologic correlation.
    Vet Comp Oncol. 13 (4): 348-62.
  13. Poggi, A. et al. (2015) Flow cytometric evaluation of ki67 for the determination of malignancy grade in canine lymphoma.
    Vet Comp Oncol. 13 (4): 475-80.
  14. Gelain ME et al. (2014) CD44 in canine leukemia: analysis of mRNA and protein expression in peripheral blood.
    Vet Immunol Immunopathol. 159 (1-2): 91-6.
  15. Paebst, F. et al. (2014) Comparative immunophenotyping of equine multipotent mesenchymal stromal cells: an approach toward a standardized definition.
    Cytometry A. 85 (8): 678-87.
  16. De Schauwer, C. et al. (2014) Characterization and profiling of immunomodulatory genes of equine mesenchymal stromal cells from non-invasive sources.
    Stem Cell Res Ther. 5 (1): 6.
  17. Claessen, C. et al. (2015) Equid herpesvirus 1 (EHV1) infection of equine mesenchymal stem cells induces a pUL56-dependent downregulation of select cell surface markers.
    Vet Microbiol. 176 (1-2): 32-9.
  18. Novacco, M. et al. (2015) Prognostic factors in canine acute leukaemias: a retrospective study.
    Vet Comp Oncol. Jan 26. [Epub ahead of print]
  19. Hillmann, A. et al. (2016) Comparative Characterization of Human and Equine Mesenchymal Stromal Cells: A Basis for Translational Studies in the Equine Model.
    Cell Transplant. 25 (1): 109-24.
  20. Moore, P.F. et al. (2013) Canine inflamed nonepitheliotropic cutaneous T-cell lymphoma: a diagnostic conundrum.
    Vet Dermatol. 24 (1): 204-11.e44-5.
  21. Nagata, K. et al. (2017) Epstein-Barr Virus Lytic Reactivation Activates B Cells Polyclonally and Induces Activation-Induced Cytidine Deaminase Expression: A Mechanism Underlying Autoimmunity and Its Contribution to Graves' Disease.
    Viral Immunol. Mar 23. [Epub ahead of print]
  22. Wessels, M. et al. (2017) Systemic necrotizing polyarteritis in three weaned lambs from one flock.
    J Vet Diagn Invest. May 1:1040638717709856. [Epub ahead of print]
  23. Uitterdijk, A. et al. (2017) Time course of VCAM-1 expression in reperfused myocardial infarction in swine and its relation to retention of intracoronary administered bone marrow-derived mononuclear cells.
    PLoS One. 12 (6): e0178779.
  24. Forner, R. et al. (2021) Distribution difference of colostrum-derived B and T cells subsets in gilts and sows.
    PLoS One. 16 (5): e0249366.
  25. Murphy, E.G. et al. (2019) First detection of Hepatitis E virus (Orthohepevirus C) in wild brown rats (Rattus norvegicus.) from Great Britain.
    Zoonoses Public Health. 66 (6): 686-94.
  26. Skovdal, S.M. et al. (2019) Inhaled nebulized glatiramer acetate against Gram-negative bacteria is not associated with adverse pulmonary reactions in healthy, young adult female pigs.
    PLoS One. 14 (10): e0223647.
  27. Collins, J.J.P. et al. (2018) Impaired Angiogenic Supportive Capacity and Altered Gene Expression Profile of Resident CD146+ Mesenchymal Stromal Cells Isolated from Hyperoxia-Injured Neonatal Rat Lungs.
    Stem Cells Dev. 27 (16): 1109-24.
  28. Matsuyama, S. et al. (2021) Properties of macrophages and lymphocytes appearing in rat renal fibrosis followed by repeated injection of cisplatin.
    J Vet Med Sci. 83 (9): 1435-42.
  29. Mu&mtilde;oz-Silvestre, A. et al. (2020) Pathogenesis of Intradermal Staphylococcal Infections: Rabbit Experimental Approach to Natural Staphylococcus aureus Skin Infections.
    Am J Pathol. 190 (6): 1188-210.
  30. Carroll, C.S.E. et al. (2021) Simple and effective bacterial-based intratumoral cancer immunotherapy.
    J Immunother Cancer. 9 (9): e002688.[Epub ahead of print].
  31. do Prado Duzanski, A. et al. (2022) Cell-mediated immunity and expression of MHC class I and class II molecules in dogs naturally infected by canine transmissible venereal tumor: Is there complete spontaneous regression outside the experimental CTVT?
    Res Vet Sci. 145: 193-204.
  32. Maciag, S.S. et al. (2022) The influence of source of porcine colostrum in development of early immune ontogeny in the piglet
    Res Sq. Mar 24 [Epub ahead of print].

Further Reading

  1. Piriou-Guzylack, L. (2008) Membrane markers of the immune cells in swine: an update.
    Vet Res. 39: 54.

Synonyms
MB-1
RRID
AB_905978
UniProt
P11912
Entrez Gene
CD79A
GO Terms
GO:0016021 integral to membrane
GO:0004888 transmembrane receptor activity
GO:0005771 multivesicular body
GO:0009897 external side of plasma membrane
GO:0019815 B cell receptor complex
GO:0030183 B cell differentiation
GO:0042100 B cell proliferation
GO:0045121 membrane raft
GO:0050853 B cell receptor signaling pathway
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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