CD79a antibody | HM57
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|Product Code||Applications||Pack Size||List Price||Your Price||Qty|
|Mouse anti Human CD79a antibody, clone HM57 recognizes an epitope within the cytoplasmic domain of CD79a. CD79a, also known as mb-1, is a 45 kDa protein that is expressed by B lymphocytes during differentiation from early pre-B cell stage through to plasma cells.
The CD79a molecule associates with CD79b (B29) to form a heterodimer that is non-covalently linked to surface immunoglobulin, forming the B-cell receptor (BCR) complex. The CD79a/CD79b heterodimers are also necessary for intracellular signaling following antigen-binding to surface immunoglobulin.
- Target Species
- Species Cross-Reactivity
Target Species Cross Reactivity Mouse Rabbit Horse Pig Monkey Rat Bovine Guinea Pig Fallow deer American Bison Red deer Ferret Goat
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- Pack Size: 25 µg, 0.2 mg, 0.1 mg
0.09% Sodium Azide (NaN3)Pack Size: 1 ml 0.09% Sodium Azide (NaN3) 1% Bovine Serum Albumin
- Carrier Free
- Synthetic peptide corresponding to 202-216 amino acid sequence of human mb-1
- Approx. Protein Concentrations
- Pack Size: 25 µg, 0.2 mg, 0.1 mgIgG concentration 1.0mg/mlPack Size: 1 mlIgG concentration 0.1mg/ml
- Fusion Partners
- Spleen cells from immunised Balb/c mice were fused with cells of the Sp2/0 myeloma cell line
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Flow Cytometry 1||1/10 Pack Size: 25 µg, 1 ml
1/50 Pack Size: 0.2 mg, 0.1 mg
|1/50 Pack Size: 25 µg
1/25 Pack Size: 1 ml
1/100 Pack Size: 0.2 mg, 0.1 mg
|Immunohistology - Frozen|
|Immunohistology - Paraffin 2||1/100||1/500|
- 1 Membrane permeabilization is required for this application. The use of Leucoperm (Product Code BUF09) is recommended for this purpose.
- 2This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
- Histology Positive Control Tissue
- Human tonsil
References for CD79a antibody
Mason, D.Y. et al. (1991) The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells.
J Immunol. 147 (11): 2474-82.
Jones, M. et al. (1993) Detection of T and B cells in many animal species using cross-reactive anti-peptide antibodies.
J Immunol. 150 (12): 5429-35.
Christgau, M. et al. (1998) Characterization of immunocompetent cells in the diseased canine periodontium.
J Histochem Cytochem. 46: 1443-54.
Spaas, J.H. et al. (2013) Culture and characterisation of equine peripheral blood mesenchymal stromal cells.
Vet J. 195 (1): 107-13.
Nelson, D.D. et al. (2010) CD8(+)/perforin(+)/WC1(-) gammadelta T cells, not CD8(+) alphabeta T cells, infiltrate vasculitis lesions of American bison (Bison bison) with experimental sheep-associated malignant catarrhal fever.
Vet Immunol Immunopathol. 136: 284-91.
De Schauwer, C. et al. (2012) In search for cross-reactivity to immunophenotype equine mesenchymal stromal cells by multicolor flow cytometry.
Cytometry A. 81 (4): 312-23.
Long, H. et al. (2016) Polyostotic Lymphoma in a Ferret (Mustela putorius furo).
J Comp Pathol. 154 (4): 341-4.
Schinköthe J >et al. (2016) Characterization of tuberculous granulomas in different stages of progression and associated tertiary lymphoid tissue in goats experimentally infected with Mycobacterium avium subsp. hominissuis.
Comp Immunol Microbiol Infect Dis. 47: 41-51.
View The Latest Product References
Bozkurt, Y.A., et al. (2014) Histological and immunohistological studies of the structure of lymph nodes in Kilis goats.
Biotech Histochem. 89(6):440-5.
Froment R & Bédard C (2016) Marked hyperphosphatasemia associated with an acute leukemia in a Great Dane.
Vet Clin Pathol. Aug 18. [Epub ahead of print]
Aresu, L. et al. (2015) Canine indolent and aggressive lymphoma: clinical spectrum with histologic correlation.
Vet Comp Oncol. 13 (4): 348-62.
Poggi, A. et al. (2015) Flow cytometric evaluation of ki67 for the determination of malignancy grade in canine lymphoma.
Vet Comp Oncol. 13 (4): 475-80.
Gelain ME et al. (2014) CD44 in canine leukemia: analysis of mRNA and protein expression in peripheral blood.
Vet Immunol Immunopathol. 159 (1-2): 91-6.
Paebst, F. et al. (2014) Comparative immunophenotyping of equine multipotent mesenchymal stromal cells: an approach toward a standardized definition.
Cytometry A. 85 (8): 678-87.
De Schauwer, C. et al. (2014) Characterization and profiling of immunomodulatory genes of equine mesenchymal stromal cells from non-invasive sources.
Stem Cell Res Ther. 5 (1): 6.
Claessen, C. et al. (2015) Equid herpesvirus 1 (EHV1) infection of equine mesenchymal stem cells induces a pUL56-dependent downregulation of select cell surface markers.
Vet Microbiol. 176 (1-2): 32-9.
Novacco, M. et al. (2015) Prognostic factors in canine acute leukaemias: a retrospective study.
Vet Comp Oncol. Jan 26. [Epub ahead of print]
Hillmann, A. et al. (2016) Comparative Characterization of Human and Equine Mesenchymal Stromal Cells: A Basis for Translational Studies in the Equine Model.
Cell Transplant. 25 (1): 109-24.
Moore, P.F. et al. (2013) Canine inflamed nonepitheliotropic cutaneous T-cell lymphoma: a diagnostic conundrum.
Vet Dermatol. 24 (1): 204-11.e44-5.
Nagata, K. et al. (2017) Epstein-Barr Virus Lytic Reactivation Activates B Cells Polyclonally and Induces Activation-Induced Cytidine Deaminase Expression: A Mechanism Underlying Autoimmunity and Its Contribution to Graves' Disease.
Viral Immunol. Mar 23. [Epub ahead of print]
Wessels, M. et al. (2017) Systemic necrotizing polyarteritis in three weaned lambs from one flock.
J Vet Diagn Invest. May 1:1040638717709856. [Epub ahead of print]
Uitterdijk, A. et al. (2017) Time course of VCAM-1 expression in reperfused myocardial infarction in swine and its relation to retention of intracoronary administered bone marrow-derived mononuclear cells.
PLoS One. 12 (6): e0178779.
Forner, R. et al. (2021) Distribution difference of colostrum-derived B and T cells subsets in gilts and sows.
PLoS One. 16 (5): e0249366.
Murphy, E.G. et al. (2019) First detection of Hepatitis E virus (Orthohepevirus C) in wild brown rats (Rattus norvegicus.) from Great Britain.
Zoonoses Public Health. 66 (6): 686-94.
Skovdal, S.M. et al. (2019) Inhaled nebulized glatiramer acetate against Gram-negative bacteria is not associated with adverse pulmonary reactions in healthy, young adult female pigs.
PLoS One. 14 (10): e0223647.
Collins, J.J.P. et al. (2018) Impaired Angiogenic Supportive Capacity and Altered Gene Expression Profile of Resident CD146+ Mesenchymal Stromal Cells Isolated from Hyperoxia-Injured Neonatal Rat Lungs.
Stem Cells Dev. 27 (16): 1109-24.
Matsuyama, S. et al. (2021) Properties of macrophages and lymphocytes appearing in rat renal fibrosis followed by repeated injection of cisplatin.
J Vet Med Sci. 83 (9): 1435-42.
Mu&mtilde;oz-Silvestre, A. et al. (2020) Pathogenesis of Intradermal Staphylococcal Infections: Rabbit Experimental Approach to Natural Staphylococcus aureus Skin Infections.
Am J Pathol. 190 (6): 1188-210.
Carroll, C.S.E. et al. (2021) Simple and effective bacterial-based intratumoral cancer immunotherapy.
J Immunother Cancer. 9 (9): e002688.[Epub ahead of print].
do Prado Duzanski, A. et al. (2022) Cell-mediated immunity and expression of MHC class I and class II molecules in dogs naturally infected by canine transmissible venereal tumor: Is there complete spontaneous regression outside the experimental CTVT?
Res Vet Sci. 145: 193-204.
Maciag, S.S. et al. (2022) The influence of source of porcine colostrum in development of early immune ontogeny in the piglet
Res Sq. Mar 24 [Epub ahead of print].
Piriou-Guzylack, L. (2008) Membrane markers of the immune cells in swine: an update.
Vet Res. 39: 54.
- Entrez Gene
- GO Terms
- GO:0016021 integral to membrane
- GO:0004888 transmembrane receptor activity
- GO:0005771 multivesicular body
- GO:0009897 external side of plasma membrane
- GO:0019815 B cell receptor complex
- GO:0030183 B cell differentiation
- GO:0042100 B cell proliferation
- GO:0045121 membrane raft
- GO:0050853 B cell receptor signaling pathway
- View More GO Terms
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