CD41 antibody | PM6/248
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Mouse anti Human CD41
- Product Type
- Monoclonal Antibody
|Mouse anti Human CD41 antibody, clone PM6/248 recognizes the human CD41 cell surface antigen, a ~140 kDa glycoprotein expressed by platelets and megakaryocytes. CD41 is also known as platelet glycoprotein IIb, and functions as a receptor for fibrinogen, fibronectin and vWF.
It has not been established if clone PM6/248 recognizes free CD41 or CD41 only when complexed with CD61. However, antibody binding is reduced in the presence of EDTA suggesting that the epitope recognized is dependent upon an intact CD41/61 complex.
- Target Species
- Species Cross-Reactivity
Target Species Cross Reactivity Baboon
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide
- Carrier Free
- Human platelet plasma membranes.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line.
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 106 cells or 100ul whole blood
References for CD41 antibody
Hornby, E.J. et al. (1991) Activation of human platelets by exposure to a monoclonal antibody, PM6/248, to glycoprotein IIb-IIIa.
Br J Haematol. 79 (2): 277-85.
Michelson, A.D. et al. (1995) A panel of platelet mAb for the study of haemostasis and thrombosis in baboons.
Leucocyte Typing V. Oxford University Press p 1230-1231.
Zahler, S. et al. (1999) Acute cardiac inflammatory responses to postischemic reperfusion during cardiopulmonary bypass.
Cardiovasc Res. 41: 722-30.
Massoudy, P. et al. (2001) Evidence for inflammatory responses of the lungs during coronary artery bypass grafting with cardiopulmonary bypass.
Chest. 119: 31-6.
Wang, J.S. et al. (2005) Effects of exercise training and deconditioning on platelet aggregation induced by alternating shear stress in men.
Arterioscler Thromb Vasc Biol. 25: 454-60.
Kahng, J. et al. (2008) Quantitative comparisons of antibody-binding sites of platelet glycoprotein IIb/IIIa in aplastic anemia and idiopathic thrombocytopenic purpura.
Ann Clin Lab Sci. 38: 6-11.
Chae, H. et al. (2009) EDTA Inhibits the Binding of Clone 96.2C1, an Anti-CD41a Monoclonal Antibody, to the Platelets and Addition of Heparin and CaCl2 to the Antibody Neutralizes the EDTA-induced Inhibitory Effect
Korean J Hematol 44: 42 - 6.
Maloney, S.F. ety al. (2010) P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions.
Integr Biol (Camb). 2: 183-92.
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Welsh, J.D. et al. (2012) Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse.
J Thromb Haemost. 10 (11): 2344-53.
Foruzanmehr, M. et al. (2014) Nano-structure TiO2 film coating on 316L stainless steel via sol-gel technique for blood compatibility improvement
Nanomedicine J. 1 (3): 128-36.
Kamat, V. et al. (2015) Microfluidic assessment of functional culture-derived platelets in human thrombi under flow.
Exp Hematol. 43 (10): 891-900.e4.
Miyazaki, K. et al. (2015) Immature platelet fraction measurement is influenced by platelet size and is a useful parameter for discrimination of macrothrombocytopenia.
Hematology. 20 (10): 587-92.
Vučetić, D. et al. (2018) Flow cytometry analysis of platelet populations: usefulness for monitoringthe storage lesion in pooled buffy-coat platelet concentrates.
Blood Transfus. 16 (1): 83-92.
Burdorf, L. et al. (2019) Thromboxane and histamine mediate PVR elevation during xenogeneic pig lung perfusion with human blood.
Xenotransplantation. 26 (2): e12458.
Miura, S. et al. (2022) Effects of human TFPI and CD47 expression and selectin and integrin inhibition during GalTKO.hCD46 pig lung perfusion with human blood.
Xenotransplantation. 29 (2): e12725.
- INTEGRIN ALPHA IIB
- Entrez Gene
- GO Terms
- GO:0002576 platelet degranulation
- GO:0004872 receptor activity
- GO:0008305 integrin complex
- GO:0007229 integrin-mediated signaling pathway
- GO:0007411 axon guidance
- GO:0042802 identical protein binding
- GO:0030168 platelet activation
- GO:0031092 platelet alpha granule membrane
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