CD239 antibody | BRIC221


Product Details
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Pig - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- TRIS buffered glycine
- Preservative Stabilisers
0.09% Sodium Azide - Immunogen
- Human erythrocytes.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
Storage Information
- Storage
- Store at +4oC or at -20oC if preferred.
This product should be stored undiluted.
Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P50895
- Entrez Gene
- BCAM
- GO Terms
- GO:0005055 laminin receptor activity
- GO:0005887 integral to plasma membrane
- GO:0007160 cell-matrix adhesion
- GO:0009897 external side of plasma membrane
- GO:0043236 laminin binding
- Regulatory
- For research purposes only
Applications of CD239 antibody
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA | |||
Flow Cytometry | |||
Immunofluorescence | |||
Immunohistology - Frozen | |||
Western Blotting 1 |
- 1Non-reducing conditions required
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Secondary Antibodies Available
Negative Isotype Controls Available
Description | Product Code | Applications | Pack Size | List Price | Quantity |
---|---|---|---|---|---|
Mouse IgG2b Negative Control | MCA691 | F | 100 Tests |
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Product Specific References
References for CD239 antibody
-
Parsons, S.F. et al. (1997) Use of domain-deletion mutants to locate Lutheran blood group antigens to each of the five immunoglobulin superfamily domains of the Lutheran glycoprotein: elucidation of the molecular basis of the Lu(a)/Lu(b) and the Au(a)/Au(b) polymorphisms.
Blood. 89 (11): 4219-25. -
Sakai, E. et al. (2007) Construction of recombinant hemagglutinin derived from the gingipain-encoding gene of Porphyromonas gingivalis, identification of its target protein on erythrocytes, and inhibition of hemagglutination by an interdomain regional peptide.
J Bacteriol. 189: 3977-86. -
Bruce, L.J. et al. (2003) A band 3-based macrocomplex of integral and peripheral proteins in the RBC membrane.
Blood. 101: 4180-8. -
Kjellgren, D. et al. (2004) Laminin isoforms in human extraocular muscles.
Invest Ophthalmol Vis Sci. 45: 4233-9. -
Vainionpää, N. et al. (2006) Laminin-10 and Lutheran blood group glycoproteins in adhesion of human endothelial cells.
Am J Physiol Cell Physiol. 290: C764-75. -
Chen, J. et al. (2009) Expression of laminin isoforms, receptors, and binding proteins unique to nucleus pulposus cells of immature intervertebral disc.
Connect Tissue Res. 50: 294-306. -
Määttä, M. et al. (2005) Differential expression of laminin isoforms in ovarian epithelial carcinomas suggesting different origin and providing tools for differential diagnosis.
J Histochem Cytochem. 53: 1293-300. -
Virtanen, I. et al. (2003) Laminin isoforms in fetal and adult human adrenal cortex.
J Clin Endocrinol Metab. 88: 4960-6. -
Kikkawa, Y. et al. (2011) An antibody to the lutheran glycoprotein (Lu) recognizing the LU4 blood type variant inhibits cell adhesion to laminin α5.
PLoS One. 6: e23329. -
Takkunen, M. et al. (2008) Epithelial-mesenchymal transition downregulates laminin alpha5 chain and upregulates laminin alpha4 chain in oral squamous carcinoma cells.
Histochem Cell Biol. 130: 509-25. -
Hasenson, S. et al. (2005) The immortalized human corneal epithelial cells adhere to laminin-10 by using Lutheran glycoproteins and integrin alpha3beta1.
Exp Eye Res. 81: 415-21. -
Liu, J.X. et al. (2011) Different impact of ALS on laminin isoforms in human extraocular muscles versus limb muscles.
Invest Ophthalmol Vis Sci. 52: 4842-52. -
Vuoristo, S. et al. (2009) Laminin isoforms in human embryonic stem cells: synthesis, receptor usage and growth support.
J Cell Mol Med. 13: 2622-33. -
Kikkawa, Y. et al. (2016) Down-regulation of cell adhesion via rho-associated protein kinase (ROCK) pathway promotes tumor cell migration on laminin-511
Experimental Cell Research. Apr 8 [Epub ahead of print] -
Vainionpää N et al. (2007) Basement membrane protein distribution in LYVE-1-immunoreactive lymphatic vessels of normal tissues and ovarian carcinomas.
Cell Tissue Res. 328 (2): 317-28. -
Kikkawa Y et al. (2014) Soluble Lutheran/basal cell adhesion molecule is detectable in plasma of hepatocellular carcinoma patients and modulates cellular interaction with laminin-511in vitro.
Exp Cell Res. 328 (1): 197-206. -
Kikkawa, Y. et al. (2008) Laminin alpha 5 mediates ectopic adhesion of hepatocellular carcinoma through integrins and/or Lutheran/basal cell adhesion molecule.
Exp Cell Res. 314 (14): 2579-90. -
Kikkawa, Y. et al. (2007) The LG1-3 tandem of laminin alpha5 harbors the binding sites of Lutheran/basal cell adhesion molecule and alpha3beta1/alpha6beta1 integrins.
J Biol Chem. 282 (20): 14853-60. -
Kikkawa, Y. et al. (2013) The lutheran/basal cell adhesion molecule promotes tumor cell migration by modulating integrin-mediated cell attachment to laminin-511 protein.
J Biol Chem. 288 (43): 30990-1001. -
Enomoto-Okawa, Y. et al. (2017) An Anti-Human Lutheran Glycoprotein Phage Antibody Inhibits Cell Migration on Laminin-511: Epitope Mapping of the Antibody.
PLoS One. 12 (1): e0167860.
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