C4d antibody | 057-126.96.36.199
|Mouse anti Human C4d (Neoantigen) antibody, clone 057-188.8.131.52 recognizes a neoantigen on the secreted protein complement component 4d (C4d). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4b’s alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonisation and activation of the classical pathway. This requires C4 binding protein or CR1 as a cofactor. iC4b is further degraded into C4d and C4c. The short half life of C4d means that it is present in serum at high enough concentrations to make it a useful marker for classical complement activation.
C4 has been linked to susceptibility to systemic lupus erythematosous.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from ascites
- Buffer Solution
- Borate buffered saline
- Preservative Stabilisers
- 0.1% Sodium Azide (NaN3)
- Purified human C4d.
- Approx. Protein Concentrations
- Current, batch-specific concentration 1.10 mg/ml
- For research purposes only
- Guaranteed until date of expiry. Please see product label.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen|
- Histology Positive Control Tissue
- Kidney from post streptoccal glomerulonephritis patients
References for C4d antibody
Rogers, J. et al. (1992) Complement activation by beta-amyloid in Alzheimer disease.
Proc Natl Acad Sci U S A. 89 (21): 10016-20.
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