C4d antibody | 057-51.5.1.6

Mouse anti Human C4d (Neoantigen)

Product Type
Monoclonal Antibody
Clone
057-51.5.1.6
Isotype
IgG1
Specificity
C4d
Region
(NEOANTIGEN)

Product Code Applications Pack Size List Price Your Price Qty
MCA2649
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C E 0.1 mg
List Price Your Price
Search for Batch Specific Datasheets

Mouse anti Human C4d (Neoantigen) antibody, clone 057-51.5.1.6 recognizes a neoantigen on the secreted protein complement component 4d (C4d). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4b’s alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonisation and activation of the classical pathway. This requires C4 binding protein or CR1 as a cofactor. iC4b is further degraded into C4d and C4c. The short half life of C4d means that it is present in serum at high enough concentrations to make it a useful marker for classical complement activation.

C4 has been linked to susceptibility to systemic lupus erythematosous.

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from ascites
Buffer Solution
Borate buffered saline
Preservative Stabilisers
0.1% Sodium Azide (NaN3)
Immunogen
Purified human C4d.
Approx. Protein Concentrations
Current, batch-specific concentration 1.10 mg/ml
Regulatory
For research purposes only
Guarantee
Guaranteed until date of expiry. Please see product label.

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Immunohistology - Frozen
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Histology Positive Control Tissue
Kidney from post streptoccal glomerulonephritis patients

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Description Goat anti Mouse IgG (H/L):DyLight®650 (Multi Species Adsorbed)
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Description Goat anti Mouse IgG (H/L):DyLight®550 (Multi Species Adsorbed)

References for C4d antibody

  1. Rogers, J. et al. (1992) Complement activation by beta-amyloid in Alzheimer disease.
    Proc Natl Acad Sci U S A. 89 (21): 10016-20.

Synonyms
Complement Component 4d
RRID
AB_871990
UniProt
P0C0L4
P0C0L5
Entrez Gene
C4A
C4B
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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