C3aR antibody | 17 (hC3aRZ8)
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Mouse anti Human C3aR
- Product Type
- Monoclonal Antibody
- Clone
- 17 (hC3aRZ8)
- Isotype
- IgG2b
- Specificity
- C3aR
Antibody Quality and Performance Guarantee
| Mouse anti Human C3aR antibody, clone 1hC3aRZ8, recognizes the human receptor of C3a (C3aR), this clone is also known in the literature as clone hC3aRZ8. C3a is a ligand to the seven-transmembrane coupled receptor C3aR. C3aR is expressed in myeloid cells including monocytes, macrophages, dendritic cells as well as T cells, endothelial, epithelial, glial cells and neurons (Wang et al. 2019). The response of C3a binding to C3aR has been shown to be cell type specific. For example, in mast cells, C3a elicits a proinflammatory histamine degranulation response, whereas on neutrophils, C3a exhibits an anti-inflammatory response, through attenuation of neutrophil mobilization into circulation after injury (Mathern & Heeger 2015). Other functionalities have included leukocyte activation, vascular permeability and chemotaxis (Wang et al. 2019). Beyond its immune related functions C3aR has been shown to facilitate osteoclast differentiation and bone formation (Ignatius et al. 2011). It has also been shown to be up-regulated in multiple sclerosis, with increased expression on glial cells (Gasque et al. 1998). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Approx. Protein Concentrations
- IgG concentration 0.1 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry |  |
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| Functional Assays | |||
| Immunohistology - Frozen | |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse IgG2b Negative Control | MCA691 | F | 100 Tests |
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| List Price | Your Price | ||||||
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| Description | Mouse IgG2b Negative Control | ||||||
- UniProt
- Q16581
- Entrez Gene
- C3AR1
- GO Terms
- GO:0004435 phosphatidylinositol phospholipase C activity
- GO:0004876 complement component C3a receptor activity
- GO:0004943 C3a anaphylatoxin receptor activity
- GO:0005887 integral to plasma membrane
- GO:0006935 chemotaxis
- GO:0006954 inflammatory response
- GO:0007204 elevation of cytosolic calcium ion concentration
- GO:0008015 blood circulation
MCA6160GA
157932
166394
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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