Alpha Fetoprotein antibody | 2I9/2 (166)
Mouse anti Human alpha fetoprotein antibody, clone 219/2 recognizes alpha fetoprotein (AFP), a member of the albuminoid superfamily. It is a ~68 kDa plasma protein found in fetuses over four weeks old, produced by the yolk sac and the fetal liver, with the highest concentration reached during the 12th to 16th week of gestation. It binds and transports various ligands such as bilirubin, fatty acids, steroids, heavy metals and various drugs. After birth, plasma levels drop to trace amounts in healthy adults
Elevated AFP levels are indicative of certain cancers, particularly hepatocellular carcinoma, cancer of the testes or ovaries or a malignant teratoma. During pregnancy increased levels of AFP may indicate neural tube defects such as spina bifida, while decreased levels could indicate Down's syndrome.
Mouse anti Human alpha fetoprotein antibody, clone 219/2 does not cross-react with human albumin and other human serum proteins.
Elevated AFP levels are indicative of certain cancers, particularly hepatocellular carcinoma, cancer of the testes or ovaries or a malignant teratoma. During pregnancy increased levels of AFP may indicate neural tube defects such as spina bifida, while decreased levels could indicate Down's syndrome.
Mouse anti Human alpha fetoprotein antibody, clone 219/2 does not cross-react with human albumin and other human serum proteins.
Product Details
- Target Species
- Human
- Product Form
- Ig fraction - liquid
- Preparation
- Ig fraction prepared by chromatography
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Human fetal cord serum.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
Storage Information
- Storage
- This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P02771
- Entrez Gene
- AFP
- GO Terms
- GO:0046872 metal ion binding
- GO:0006810 transport
- Regulatory
- For research purposes only
Applications of Alpha Fetoprotein antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
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