Myelin Proteolipid Protein antibody | plpc1
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|Mouse anti myelin proteolipid protein antibody, clone plpc1 recognizes myelin proteolipid protein (PLP) in many mammalian species (Stoffel et al. 1985). Clone plpc1 also recognizes the alternative PLP splice variant lacking part of the cytoplasmic domain (amino acids 117-151), known as DM20 (Simons et al. 1987) .
PLP encodes the major protein components of compact CNS myelin and mutations in the PLP gene can lead to severe dysmyelinating disease (Hudson et al. 1989).
Mouse anti myelin proteolipid protein, clone plpc1 has proved a useful immunohistochemical tool for the study of central nervous system injury in patients with multiple sclerosis (Seewan et al. 2011, Huizinga et al. 2011)
- Target Species
- Species Cross-Reactivity
Target Species Cross Reactivity Human Tenerife lizard (Gallotia galloti)
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Synthetic peptide GRGTKF corresponding to C terminal region of myelin proteolipid protein.
- Approx. Protein Concentrations
- IgG concentration 1 mg/ml
- Fusion Partners
- Spleen cells from immunized BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line.
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen|
|Immunohistology - Paraffin|
References for Myelin Proteolipid Protein antibody
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Grade, S. et al. (2010) Functional identification of neural stem cell-derived oligodendrocytes by means of calcium transients elicited by thrombin.
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Moharregh-Khiabani, D. et al. (2010) Effects of fumaric acids on cuprizone induced central nervous system de- and remyelination in the mouse.
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Bramow, S. et al. (2010) Demyelination versus remyelination in progressive multiple sclerosis.
Kooij, G. et al. (2010) Adenosine triphosphate-binding cassette transporters mediate chemokine (C-C motif) ligand 2 secretion from reactive astrocytes: relevance to multiple sclerosis pathogenesis.
Brain. 134: 555-70.
Jaśkiewicz, E. et al. (2005) Expression of recombinant forms of human 21.5 kDa myelin basic protein and proteolipid protein in CHO cells.
Acta. Biochim. Pol. 52: 863-6.
Coulpier, F. et al. (2010) CNS/PNS boundary transgression by central glia in the absence of Schwann cells or Krox20/Egr2 function.
J Neurosci. 30: 5958-67.
Gilmore, C.P. et al. (2006) Spinal cord gray matter demyelination in multiple sclerosis-a novel pattern of residual plaque morphology.
Brain Pathol. 16: 202-8.
View The Latest Product References
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Baeten, K. et al. (2011) Tracking of myelin-reactive T cells in experimental autoimmune encephalomyelitis (EAE) animals using small particles of iron oxide and MRI.
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