Myelin Proteolipid Protein antibody | plpc1
Mouse anti myelin proteolipid protein antibody, clone plpc1 (MCA839G) used for the detection of proteolipid protein on formalin fixed, paraffin embedded brain tissue.
Image caption:
NL scheme and PLP staining. (A) Type-I NL with demyelination of the whole width of the cortex (#) and adjacent WM (*). (B) Type-II intracortical lesion evolving around a vessel. (C) Type-III subpial NL. Demyelination spreads from the pial surface until cortical layer 3. Scale bars represent 500 μm.
From:
Yao B, Hametner S, van Gelderen P, Merkle H, Chen C, et al. (2014)
7 Tesla Magnetic Resonance Imaging to Detect Cortical Pathology in Multiple Sclerosis.
PLoS ONE 9(10): e108863.
This image is from an open access article distributed under the terms of a Creative Commons Attribution License.
Mouse anti myelin proteolipid protein antibody, clone plpc1 (MCA839G) used for the detection of proteolipid protein on formalin fixed, paraffin embedded brain tissue.
Image caption:
NLs on MRI and tissue sections stained for PLP and iron. Examples Examples of NLs from tissue MS1 (A, B and C) identified on MRI magnitude (TE = 25.2 ms) and R2* images as well as color-coded PLP-staining and iron staining. Red arrows point towards NLs identified by MRI and confirmed to correspond to area of demyelination by the color-coded PLP staining. Blue arrows point towards NLs identified by the color-coded PLP staining and only retrospectively identified by MRI. Black arrows and black box point towards NLs identified by the color-coded PLP staining and not by MRI even upon a second retrospective image inspection. In the black box we include a large area of demyelination which goes entirely undetected by MRI. In the color-coded PLP staining of figure: green = complete WM demyelination, red = complete GM demyelination, yellow = areas of variably reduced myelin density.
From:
Yao B, Hametner S, van Gelderen P, Merkle H, Chen C, et al. (2014)
7 Tesla Magnetic Resonance Imaging to Detect Cortical Pathology in Multiple Sclerosis.
PLoS ONE 9(10): e108863.
This image is from an open access article distributed under the terms of a Creative Commons Attribution License.
Mouse anti myelin proteolipid protein antibody, clone plpc1 (MCA839G) used for the detection of proteolipid protein on formalin fixed, paraffin embedded brain tissue.
Image caption:
Iron loss in NLs. PLP myelin staining (B) and iron staining (C) on two consecutive slides of tissue MS2 disclose iron loss together with myelin loss in a NL (red arrows). Higher magnification (D, E, F, G) of PLP (D, F) and iron stainings (E, G). In NAGM (D, E), iron is present in oligodendrocytes (black arrow and inset in E) and myelin sheaths. In a NL (F, G), iron is removed from the demyelinated cortical parenchyma and present in perivascular macrophages and microglia (black arrow and inset in G).
From:
Yao B, Hametner S, van Gelderen P, Merkle H, Chen C, et al. (2014)
7 Tesla Magnetic Resonance Imaging to Detect Cortical Pathology in Multiple Sclerosis.
PLoS ONE 9(10): e108863.
This image is from an open access article distributed under the terms of a Creative Commons Attribution License.
Mouse anti myelin proteolipid protein antibody, clone plpc1 (MCA839G) used for detection of myelin proteolipid protein in human and porcine brain lysates by western blotting
Image caption:
Validation of monomer and oligomer preference of αSN interacting proteins. Proteins pulled down by monomer αSN (M), oligomer αSN (O), and buffer control (B) from porcine (A-F) and human (G-I) brain extracts were analyzed by immunoblotting using antibodies against antigens selected among the monomer and oligomer binding proteins. Monomer binding antigens were myelin proteolipid protein (mPLP) and Abl interactor 1 (Abl1) and oligomer binding proteins were glial fibrillary acidic protein (GFAP), glutamate decarboxylase 2 (GAD2), and synapsin 1 (Syn1). VAMP-2 was tested because it has been reported to bind &apha;SN, although it was not detected in our proteomic analysis. One representative of three experiments is presented for porcine αSN binding proteins (A, C, E), and the quantification of the three experiments is presented in panels B, D, F. The quantification of bands was performed after subtracting the non-specific signal in the buffer control from the specific bands in monomer and oligomer samples. Bars represent mean ratio between monomer and oligomer ± S.D. of the three replicates. The values for binding to monomer and oligomer were compared by Student's t-test and the resulting p-values are listed above the bars. * Indicates that the band intensity from oligomer did not differ significantly from background making quantifications impracticable. In order to ensure that the interaction were not due to species differences between human and porcine proteins we conducted validations in human brain extracts. One representative of two experiments is presented for each validated protein. The validation for both porcine and human of mPLP, Abl1, Syn1 and VAMP-2 was conducted in the LP2 fraction enriched in synaptic vesicle and the validation to GFAP and GAD2 in the LS1 fraction of synaptosomal lysate.
From: Betzer C, Movius AJ, Shi M, Gai W-P, Zhang J, et al. (2015) Identification of Synaptosomal Proteins Binding to Monomeric and Oligomeric α-Synuclein.
PLoS ONE 10(2): e0116473.
This image is from an open access article distributed under the terms of a Creative Commons Attribution License.
Mouse anti myelin proteolipid protein antibody, clone plpc1 (MCA839G) used for detection of proteolipid protein in formalin fixed, paraffin embedded multiple sclerosis brain tissue.
Image caption:
Microglia associated with preactive lesions express NADPH oxidase-2 subunits. Clusters of HLA-DR immunopositive microglia (B and C, HLA-DR) in NAWM (PLP, A) express various NADPH oxidase-2 subunits, including gp91phox (D), p22phox (E) and p47phox (F) in consecutive sections. Figure1C-F represents a magnification of the outlined square in Figure1B. Original magnifications A, B: 4×, C-F: 40×.
From: van Horssen J, Singh S, van der Pol S, Kipp M, Lim JL, Peferoen L, Gerritsen W, Kooi EJ, Witte ME, Geurts JJ, de Vries HE, Peferoen-Baert R, van den Elsen PJ, van der Valk P, Amor S.
Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation.
J Neuroinflammation. 2012 Jul 2;9:156.
This image is from an open access article distributed under the terms of a Creative Commons Attribution License.
Mouse anti myelin proteolipid protein antibody, clone plpc1 (MCA839G) used for detection of proteolipid protein in formalin fixed, paraffin embedded multiple sclerosis brain tissue
Image caption:
Preactive lesions are composed of clusters of HLA-DR-positive microglia. In NAWM, i.e., in the absence of apparent myelin loss (A, E: proteolipid protein) preactive lesions are defined as circumscribed nodules of activated microglia expressing HLA-DR (B, C) and CD68 (D). Preactive lesions are predominantly observed in blocks containing active lesions (E: proteolipid protein; F, G: HLA-DR). Figure1G represents a magnification of the outlined square in (F). In some cases microglial nodules are surrounded by a halo devoid of microglia (H: HLA-DR). Original magnifications: A, B: 20×; C, D: 40×; E, F: 4×; G, H: 40×.
From: van Horssen J, Singh S, van der Pol S, Kipp M, Lim JL, Peferoen L, Gerritsen W, Kooi EJ, Witte ME, Geurts JJ, de Vries HE, Peferoen-Baert R, van den Elsen PJ, van der Valk P, Amor S.
Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation.
J Neuroinflammation. 2012 Jul 2;9:156.
This image is from an open access article distributed under the terms of a Creative Commons Attribution License.
Mouse anti myelin proteolipid protein antibody, clone plpc1 (MCA839G) used for detection of myelin proteolipid protein in brain lysates by western blotting
Image caption:
Presence of &apha;SN binding proteins chosen for validation in synaptosomal fractions. 30μg of each of the fractions synaptosomal membranes LP1, synaptosomal lysate (LS1), synaptic vesicles (LP2) and synaptosomal cytosol (LS2) were immunoblotted, and analyzed for the presence of myelin Proteolipid protein (mPLP), Abl interactor 1 (Abl1), Glial fibrillary acidic protein (GFAP), Glutamic acid decarboxylase 2 (GAD2), Synapsin 1 (Syn1), and Vesicle associated membrane protein 2 (VAMP2).
From: Betzer C, Movius AJ, Shi M, Gai W-P, Zhang J, et al. (2015)
Identification of Synaptosomal Proteins Binding to Monomeric and Oligomeric α-Synuclein.
PLoS ONE 10(2): e0116473.
This image is from an open access article distributed under the terms of a Creative Commons Attribution License.
Mouse anti Myelin proteolipid protein, clone plpc1 (MCA839G) used for the evaluation of PLP expression in human brain by immunohistochemistry on formalin fixed, paraffin embedded biopsy sections.
Image caption:
LRP1 expression is increased in MS lesions. a Immunohistochemistry on consecutive sections from an early active (EA) MS lesion (upper row) shows: (1) myelin (PLP) laden macrophages consistent with ongoing demyelinating activity, (2) abundant macrophage infiltration (CD68), (3) hypertrophic reactive astrocytes indicating gliosis (GFAP), and (4) LRP1 immunoreactivity present on both astrocytes (arrowhead) and macrophages (arrow and inset). In contrast, the periplaque gray matter (PPGM, lower row) shows: (1) normal appearing myelin (PLP), (2) limited microglial reactivity (CD68), (3) astrocytes with regular size and morphology (GFAP), and (4) limited LRP1 immunoreactivity. (Scale bars = 20 μm). b Luxol Fast Blue histology (LFB) and immunofluorescence for CD68 and LRP1 shows that myeloid cells express LRP1 within the lesion (Scale bar = 100 μm)
From: Chuang TY, Guo Y, Seki SM, Rosen AM, Johanson DM, Mandell JW, Lucchinetti CF, Gaultier A.
LRP1 expression in microglia is protective during CNS autoimmunity.
Acta Neuropathol Commun. 2016 Jul 11;4(1):68.
This image is from an open access article distributed under the terms of a Creative Commons Attribution License.
Mouse anti myelin proteolipid protein antibody, clone plpc1 (MCA839G) used for the evaluation of PLP expression in human brain by immuohistochemistry on formalin fixed, paraffin embedded tissue sections.
Image caption:
Basic Pathology of HAE: a: Topographical distribution of demyelinated lesions in the brain shows the prominent periventricular demyelination with peri-venous extensions (Dawson Fingers) and demyelinated plaques in the cortex and the deep grey matter nuclei; green: white matter lesions, red: cortical and hippocampal lesions, blue: lesions in thalamus and basal ganglia; the blue dots in the meninges show the location of prominent meningeal inflammatory infiltrates; b: Sections stained with luxol fast blue depicts the demyelinated lesions in the white matter; c: Immunocytochemistry for CD68 shows the accumulation of macrophages at the edge of active white matter lesions; d: Double staining for proteolipid (PLP) protein (red) and mRNA (black) reveals loss of oligodendrocytes within the lesion and the presence of numerous macrophages with PLP degradation products at the lesion edge; e: In sections stained for phosphorylated neurofilament only a mild to moderate reduction of axonal density is seen in the lesions; the insert shows a neuron in the substantia nigra with an α-synuclein reactive Lewy body. f: The section stained for iron shows prominent iron accumulation in the deep grey matter nuclei and at the cortico/subcortical border; some increased iron reactivity is seen within the periventricular demyelinated lesions: g: Subpial cortical lesion in the insular cortex (Fig. 1a) with selective loss of myelin in the cortex; h, i: The subpial lesions shows an actively demyelinating edge with high density of activated microglia (Iba-1, Fig. 1h), expressing the phagocytosis associated marker CD68 (Fig. 1i). j, k: In the meninges, covering the active lesion, inflammatory infiltrates are seen, composed or perivascular T-cells (CD3, Fig. 1j) and B-cells (CD20, Fig. 1k); l: The active lesion edge of the cortical lesions contains numerous macrophages with PLP reactive myelin degradation products; m: Activated microglia and macrophages at the lesions edge express NADPH oxidase.
From: Höftberger R, Leisser M, Bauer J, Lassmann H.
Autoimmune encephalitis in humans: how closely does it reflect multiple sclerosis?
Acta Neuropathol Commun. 2015 Dec 4;3:80.
This image is from an open access article distributed under the terms of a Creative Commons Attribution License.
Mouse anti myelin proteolipid glycoprotein antibody, clone plpc1 (MCA839G) used for the demonstration of plp expression in brain tissue from multiple sclerosis affected specimens.
Image caption:
Side-by-side R2* (A), LFB (B), PLP (C) and TBB (iron, D) staining. One can appreciate examples of ROIs showing WM-L (solid red arrow on PLP and R2* maps), DWMI (dashed red arrow on PLP and R2* maps), and areas of increased iron accumulation in the dGM (red rectangle on TBB and R2* maps).
From: Bagnato F, Hametner S, Boyd E, Endmayr V, Shi Y, Ikonomidou V, et al. (2018)
Untangling the R2* contrast in multiple sclerosis: A combined MRI-histology study at 7.0 Tesla.
PLoS ONE 13(3): e0193839.
This image is from an open access article distributed under the terms of a Creative Commons Attribution License.
Mouse anti myelin proteolipid protein antibody, clone plpc1 (MCA839G) used for the visualization of myelin in a model of experimental autoimmune encephalomyelitis in rhesus monkey brain by immunohistochemistry on formalin fixed paraffin embedded tissue sections.
Image caption:
Expression of oxidative stress pathway markers.
Expression of key markers of the oxidative stress pathway was analyzed by immunohistochemistry. Shown is a representative brain area with EAE lesions stained for PLP (A), MRP14 (B) and Iba-1 (C). Image scale bars are 500 μm.
From: Dunham J, van de Vis R, Bauer J, Wubben J, van Driel N, Laman JD, et al. (2017)
Severe oxidative stress in an acute inflammatory demyelinating model in the rhesus monkey.
PLoS ONE 12(11): e0188013.
This image is from an open access article distributed under the terms of a Creative Commons Attribution License.
Mouse anti myelin proteolipid protein antibody, clone plpc1 (MCA839G) used for the visualization of myelin in a model of experimental autoimmune encephalomyelitis in rhesus monkey brain by immunohistochemistry on formalin fixed paraffin embedded tissue sections.
Image caption:
Characterization of rhesus monkey EAE brain pathology.
Tissue was stained for myelin (PLP)The image scale bar is 100 μm.
From: Dunham J, van de Vis R, Bauer J, Wubben J, van Driel N, Laman JD, et al. (2017)
Severe oxidative stress in an acute inflammatory demyelinating model in the rhesus monkey.
PLoS ONE 12(11): e0188013.
This image is from an open access article distributed under the terms of a Creative Commons Attribution License.
Mouse anti myelin proteolipid protein antibody, clone plpc1 (MCA839G) used for the visualization of myelin in a model of experimental autoimmune encephalomyelitis in rhesus monkey brain by immunohistochemistry on formalin fixed paraffin embedded tissue sections.
Image caption:
Iron accumulates in rhesus brain.
To determine tissue specific iron, Turnbull staining was performed on healthy control and EAE brain tissue from rhesus monkeys. Shown are overview images of PLP (A,D), MRP14 (B,E), and Turnbull (C,F) of a control brain (A-C) and an EAE brain (D-F). In the control brain, iron accumulation was strongest in the GM (A,C). In the EAE brain no distinct pattern of iron staining emerged. Image scale bars are 200 μm (open square).
From: Dunham J, van de Vis R, Bauer J, Wubben J, van Driel N, Laman JD, et al. (2017)
Severe oxidative stress in an acute inflammatory demyelinating model in the rhesus monkey.
PLoS ONE 12(11): e0188013.
This image is from an open access article distributed under the terms of a Creative Commons Attribution License.
Mouse anti myelin proteolipid protein antibody, clone plpc1 (MCA839G) used for the visualization of myelin in a model of experimental autoimmune encephalomyelitis in rhesus monkey brain by immunohistochemistry on formalin fixed paraffin embedded tissue sections.
Image caption:
Iron and oxidative stress.
Shown are adjacent stains of PLP (A), MRP14 (B), p22phox (C), SOD2 (D) and Iron (E) of an EAE lesion. The image scale bar is 100 μm.
From: Dunham J, van de Vis R, Bauer J, Wubben J, van Driel N, Laman JD, et al. (2017)
Severe oxidative stress in an acute inflammatory demyelinating model in the rhesus monkey.
PLoS ONE 12(11): e0188013.
This image is from an open access article distributed under the terms of a Creative Commons Attribution License.
Mouse anti Human myelin proteolipid protein, clone plpc1 (MCA839G) used for the demonstration of plp expressing cells in the spinal cord of a Vanishing White Matter disease patient by immunohistochemistry on formalin fixed, paraffin embedded tissue sections.
Image caption:
The glial cells in the spinal cord white matter of a VWM patient are affected. Stains on a cross‐section of lateral white matter of the thoracic spinal cord of (a, g and m) a healthy control, and (b,h, and o) VWM patient VWM367. Stains are performed for (a–c) H&E; (g–I) nestin; (m–o) PLP. Arrows indicate examples of (I) a nestin‐expressing cell. Scale bar 75 μm.
From: Leferink PS, Breeuwsma N, Bugiani M, van der Knaap MS, Heine VM.
Affected astrocytes in the spinal cord of the leukodystrophy vanishing white matter.
Glia. 2018 Apr;66(4):862-73.
doi: 10.1002/glia.23289.
This image is from an open access article distributed under the terms of a Creative Commons Attribution License.
Mouse anti Myelin Proteolipid Protein antibody, clone plpc1 (MCA839G) used to demonstrate myelin in mouse brain section by immunohistochemistry on vibratome sections.
Image caption:
Histology and IHC of Myelin. Histological staining using Black Gold II, and IHC for CNPase and PLP of hippocampus (upper panels) and higher magnifications of TA (*) and PP (+) in respectively CA1 SLM and molecular layer of the DG (lower panels). Scale bars: upper panels:400 µm; lower panels: 100 μm.
From: Maurin H, Seymour CM, Lechat B, Borghgraef P, Devijver H, Jaworski T, et al. (2013)
Tauopathy Differentially Affects Cell Adhesion Molecules in Mouse Brain: Early Down-Regulation of Nectin-3 in Stratum Lacunosum Moleculare.
PLoS ONE 8(5): e63589.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Mouse anti Human myelin proteolipid protein antibody, clone plpc1 (MCA839G) used to stain myelin in human brain tissue by immunohistochemistry on human white matter tissue sections.
Image caption:
Protein expression of MC4R in MS lesions. Immunostainings of representative control white matter, NAWM, an active lesion, and inactive lesion center. Active MS lesions are characterized by loss of proteolipid protein (PLP) and presence of MHCII positive leukocytes, while inactive lesions are characterized by a demyelinated core, with little presence of MHCII+ cells. MC4R is expressed in control and NAWM and increased immunoreactivity is observed in active lesions (open arrowheads, scale-bar = 25 μm).
From:Kamermans A, Verhoeven T, van Het Hof B, Koning JJ, Borghuis L, Witte M, van Horssen J, de Vries HE, Rijnsburger M.
Setmelanotide, a Novel, Selective Melanocortin Receptor-4 Agonist Exerts Anti-inflammatory Actions in Astrocytes and Promotes an Anti-inflammatory Macrophage Phenotype.
Front Immunol. 2019 Oct 4;10:2312.
doi: 10.3389/fimmu.2019.02312.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Mouse anti myelin proteolipid protein antibody, clone plpc1 (MCA839G) used to demonstrate myelin in brain of Huntington's disease patients by immunohistochemistry on formalin fixed paraffin embedded tissue sections.
Image caption:
Macroscopic colocalization of MRI and histological staining for iron and immunohistological visualization of myelin. (A) Control subject showed macroscopic colocalization of the small focal hypointensities on MRI with small regions of increased staining intensity in both the iron and myelin staining. (B) HD patients exhibited larger focal hypointensities within the caudate nucleus and putamen. Histology showed high iron, but low myelin staining intensity within these regions. The hypointensities as observed on MRI frequently colocalized with vessels and enlarged perivascular spaces.CN = caudate nucleus; PT = putamen; IC = internal capsule; WM = white matter. Scale bar = 1 cm.
From: Bulk, M. et al.
Pathological characterization of T2*-weighted MRI contrast in the striatum of Huntington’s disease patients.
NeuroImage: Clinical 28, 2020, 102498.
doi: 10.1016/j.nicl.2020.102498
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Mouse anti myelin proteolipid protein antibody, clone plpc1 (MCA839G) used to demonstrate myelin in brain of Huntington's disease patients by immunohistochemistry on formalin fixed paraffin embedded tissue sections.
Image caption:
Macroscopic structures affecting the MRI contrast in control subjects and HD patients. (A) Small focal hypointensities on MRI originated from myelinated fiber bundles traversing the caudate nucleus and putamen, which were also characterized by high iron concentrations.
From: Bulk, M. et al.
Pathological characterization of T2*-weighted MRI contrast in the striatum of Huntington’s disease patients.
NeuroImage: Clinical 28, 2020, 102498.
doi: 10.1016/j.nicl.2020.102498
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Mouse anti myelin proteolipid protein antibody, clone plpc1 (MCA839G) used to demonstrate myelin staining in human post mortem brain tissue by immunohistochemistry on cryostat sections.
Image caption:
Representative brain sections of control white matter (CON, upper image; scale bar = 1 mm) and normal appearing white matter (NAWM) as well as lesion-enriched white matter (Lesion) of donors with MS pathology (lower image; scale bar = 1 mm). NAWM tissue shows ramified microglia and intact myelin, based on HLA-DR and PLP staining, respectively. In active lesion, demyelinated center and active microglia/macrophages could be detected throughout the whole lesion. The majority of HLADR+ cells in lesion MS are foamy microglia/macrophages. Scale bar of high resolution pictures is 50 μm.
From: Böttcher C, van der Poel M, Fernández-Zapata C, Schlickeiser S, Leman JKH, Hsiao CC, Mizee MR, Adelia, Vincenten MCJ, Kunkel D, Huitinga I, Hamann J, Priller J.
Single-cell mass cytometry reveals complex myeloid cell composition in active lesions of progressive multiple sclerosis.
Acta Neuropathol Commun. 2020 Aug 18;8(1):136.
doi: 10.1186/s40478-020-01010-8.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Mouse anti myelin proteolipid protein antibody, clone plpc1 (MCA839G) used to label myelin in human brain by immunohistochemistry on formalin fixed, paraffin embedded tissue sections.
Image caption:
Representative images of PLP, MHC-II, TMEM119 and P2RY12 (j, k, l) immunoreactivity in in pre-active lesions (m, n, o, p). Scalebars (m-p) = 50 μm
From: van Wageningen TA, Vlaar E, Kooij G, Jongenelen CAM, Geurts JJG, van Dam AM.
Regulation of microglial TMEM119 and P2RY12 immunoreactivity in multiple sclerosis white and grey matter lesions is dependent on their inflammatory environment.
Acta Neuropathol Commun. 2019 Dec 11;7(1):206.
doi: 10.1186/s40478-019-0850-z.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Mouse anti myelin proteolipid protein antibody, clone plpc1 (MCA839G) used to stain PLP in mouse brains by immunohistochemistry on formalin fixed, paraffin embedded tissue sections
Image caption:
Ermin positive cell density in MS white matter lesions.
Myelin proteolipid protein (PLP) stained tissue section (** represents remyelinated white matter area and demyelinated white matter area is represented by ##); insertion A1 shows a demyelinated area with no remyelination, and insertion (A2) shows a partly remyelinated area
From: Ahmad I, Wergeland S, Oveland E, Bø L (2021)
A higher proportion of ermin-immunopositive oligodendrocytes in areas of remyelination.
PLoS ONE 16(8): e0256155.
doi: 10.1371/journal.pone.0256155
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Mouse anti myelin proteolipid protein antibody, clone plpc1 (MCA839G) used to stain PLP in mouse brains by immunohistochemistry on formalin fixed, paraffin embedded tissue sections
Image caption:
Ermin positive cell density in MS gray matter lesions.
Myelin proteolipid protein (PLP) stained tissue section (** represents remyelinated area, demyelinated area is represented by ##); the insertion A1 shows an area of complete demyelination in gray matter. The insertion A2 shows partial remyelination.
From: Ahmad I, Wergeland S, Oveland E, Bø L (2021)
A higher proportion of ermin-immunopositive oligodendrocytes in areas of remyelination.
PLoS ONE 16(8): e0256155.
doi: 10.1371/journal.pone.0256155
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Mouse anti myelin proteolipid protein antibody, clone plpc1 (MCA839G) used to label plp expressing cells in human CNS cultures by immunofluorescence.
Image caption:
Effect of human CCL5 and UV treatment in CNS cultures. (A) CCL5 treatment (100 ng/mL) of rat CNS cultures from DIV 16 until DIV 24. Representative images of a control culture and a human CCL5 treated culture at DIV 24 are shown. Myelin and axons are shown by the immunofluorescence labeling of PLP (green signal) and NF (red signal). Graphs show the quantification of myelin and axons on DIV 24 per field of view of a captured image by CellProfiler software. Values for CCL5-treated cultures were normalized to control. Scale bar = 100μm; n = 7; Mean ± SEM; paired t-test; ** p <0.01. (B) Supernatant of mock- or ZIKV-infected immature mouse CNS cultures was collected at 6 dpi and UV-treated to inactivate viral particles. UV-treated supernatant was mixed 3:1 with fresh medium. Analysis by IF at 6 dpt onto immature cultures. Representative images of myelin staining (MBP, green signal; PLP, red signal) and axon (NF, red signal) staining at 6 dpt (DIV 24) are shown (n = 2). Inset images (upper panels) depict ZIKV (ZIKV E, green signal) infected CNS cells and pathology in cultures used for supernatant collection (6 dpi, DIV 24), with myelin (MBP, green signal; PLP, red signal) and neurofilament (NF, red) shown. Scale bar = 100μm.
From: Schultz V, Cumberworth SL, Gu Q, Johnson N, Donald CL, McCanney GA, Barrie JA, Da Silva Filipe A, Linington C, Willison HJ, Edgar JM, Barnett SC, Kohl A. Zika Virus Infection Leads to Demyelination and Axonal Injury in Mature CNS Cultures. Viruses. 2021 Jan 11;13(1):91. doi: 10.3390/v13010091.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Mouse anti myelin proteolipid protein antibody, clone plpc1 (MCA839G) used to label plp expressing cells in human CNS cultures by immunofluorescence.
Image caption:
ZIKV infection causes damage to mature, myelinated CNS cultures.
(B,C) IF analysis of myelin (PLP, red signal) and axons (β-Tubulin III, red signal). ZIKV infection was assessed with an antibody recognising ZIKV E protein (green signal). A total of four biological replicates (n = 4) were analyzed.
From: Schultz V, Cumberworth SL, Gu Q, Johnson N, Donald CL, McCanney GA, Barrie JA, Da Silva Filipe A, Linington C, Willison HJ, Edgar JM, Barnett SC, Kohl A. Zika Virus Infection Leads to Demyelination and Axonal Injury in Mature CNS Cultures. Viruses. 2021 Jan 11;13(1):91. doi: 10.3390/v13010091.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Mouse anti myelin proteolipid protein antibody, clone plpc1 (MCA839G) used to label myelin in human brain by immunohistochemistry on formalin fixed, paraffin embedded tissue sections.
Image caption:
h–j The more peripheral hemispheric white matter shows massive activation of microglia with ameboid morphology (h, IBA-1), lack of myelin (i, proteolipid protein stain for myelin) and loss of oligodendrocytes by apoptosis (j, CASP3 stain for apoptotic cells).
From: Vanoevelen JM, Bierau J, Grashorn JC, Lambrichs E, Kamsteeg EJ, Bok LA, Wevers RA, van der Knaap MS, Bugiani M, Frisk JH, Colnaghi R, O'Driscoll M, Hellebrekers DMEI, Rodenburg R, Ferreira CR, Brunner HG, van den Wijngaard A, Abdel-Salam GMH, Wang L, Stumpel CTRM.
DTYMK is essential for genome integrity and neuronal survival.
Acta Neuropathol. 2021 Dec 17 [Epub ahead of print]..
doi: 10.1007/s00401-021-02394-0.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Mouse anti myelin proteolipid protein antibody, clone plpc1 (MCA839G) used to stain myelin in normal appearing white matter (NAWM) and white matter lesions (WML) from human brain by immunohistochemistry of formalin fixed, paraffin embedded tissue sections.
Image caption:
Representative images of DAB staining for PLP that was used for sample scoring.
From: Miedema A, Gerrits E, Brouwer N, Jiang Q, Kracht L, Meijer M, Nutma E, Peferoen-Baert R, Pijnacker ATE, Wesseling EM, Wijering MHC, Gabius HJ, Amor S, Eggen BJL, Kooistra SM.
Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter.
Acta Neuropathol Commun. 2022 Jan 28;10(1):8.
doi: 10.1186/s40478-021-01306-3.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Mouse anti Myelin Proteolipid Protein antibody, clone plpc1 (MCA839G) used to label myelin in mouse brain by immunofluorescence of formalin fixed paraffin embedded sections.
Image caption:
The course of de- and remyelination in representative brain regions of C57BL/6 mice exposed to cuprizone. Double immunofluorescence staining with antibodies against the myelin marker proteolipid protein (PLP) was performed to visualize the course of de- and remyelination in the midline (a) and lateral parts of corpus callosum (b), cerebral cortex (c) (represented layers V–VI), and hippocampal areas CA3 (d) and dentate gyrus (e) and in C57BL/6 mice exposed to cuprizone (nuclei were counterstained with DAPI). Representative pictures in the first column show the corresponding regions with intact myelin of untreated animals (week 0). Cuprizone feeding provoked a progressive loss of myelin (middle columns), with nearly complete demyelination at week 5 in all studied brain regions except for the lateral part of the corpus callosum, where only partial demyelination occurred (third column). Finally, re-expression of PLP could be observed 2 weeks after cuprizone withdrawal during remyelination (last column). Scale bars: 20μm (a, c, d, e); 50μm (b)
From: Castillo-Rodriguez, M.d.A., Gingele, S., Schröder, LJ. et al.
Astroglial and oligodendroglial markers in the cuprizone animal model for de- and remyelination.
Histochem Cell Biol (2022) Apr 05 [Epub ahead of print].
doi: 10.1007/s00418-022-02096-y
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Mouse anti myelin proteolipid protein antibody, clone plpc1 (MCA839G) used to identify plp expression in human mesial precentral gyrus by immunohistochemistry on formalin fixed, paraffin embedded archival tissue sections.
Image caption:
Representative immunohistochemistry. Control cases left column. MS cases right column. PLP (A, B), NeuN (C, D), CD68 (E, F), TMEM119 (G, H), Iba1 (I, J), GFAP (K, L). Scale bar 50μm.
From: Yates RL, Pansieri J, Li Q, Bell JS, Yee SA, Palace J, Esiri MM, DeLuca GC.
The influence of HLA-DRB1*15 on the relationship between microglia and neurons in multiple sclerosis normal appearing cortical grey matter.
Brain Pathol. 2022 Jul;32 (4): e13041.
doi: 10.1111/bpa.13041.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Mouse anti myelin proteolipid protein antibody, clone plpc1 (MCA839G) used to evaluate PLP expression levels in human neural samples by western blotting.
Image caption:
Validation of the distinct involvement of proteins in FTD subtypes using immunoblotting. (B) Analysis of PLP1 in temporal cortical tissues. Annotated immunoblots used for the analysis of PLP1 antibody signals (chemi channel) are shown. Average protein signals are quantified and shown in dot plots. Differences in protein expression levels were analysed per group comparison using a Student’s t-test. PLP1 shows a lower expression in both FTD-GRN (0.44x) and FTD-MAPT (0.39x) compared to NDC, with a strong trend for FTD-MAPT (p = 0.0595). All five independent samples show comparable expression levels to those of the original cohort. Numbers represent apparent molecular weights in kDa. Letters represent sample annotations. Protein signal values are corrected for gel loading differences and are normalized to NDC samples. G; FTD-GRN sample, GN; FTD-GRN sample from the independent cohort, M; FTD-MAPT sample, MN; FTD-MAPT sample from the independent cohort, N; non-demented control sample.
From: Miedema SSM, Mol MO, Koopmans FTW, Hondius DC, van Nierop P, Menden K, de Veij Mestdagh CF, van Rooij J, Ganz AB, Paliukhovich I, Melhem S, Li KW, Holstege H, Rizzu P, van Kesteren RE, van Swieten JC, Heutink P, Smit AB.
Distinct cell type-specific protein signatures in GRN and MAPT genetic subtypes of frontotemporal dementia.
Acta Neuropathol Commun. 2022 Jul 7;10(1):100.
doi: 10.1186/s40478-022-01387-8.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
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P WB C IF ResetMouse anti Myelin Proteolipid Protein
- Product Type
- Monoclonal Antibody
- Clone
- plpc1
- Isotype
- IgG2a
- Specificity
- Myelin Proteolipid Protein
Antibody Quality and Performance Guarantee
| Mouse anti myelin proteolipid protein antibody, clone plpc1 recognizes myelin proteolipid protein (PLP) in many mammalian species (Stoffel et al. 1985). Clone plpc1 also recognizes the alternative PLP splice variant lacking part of the cytoplasmic domain (amino acids 117-151), known as DM20 (Simons et al. 1987) . PLP encodes the major protein components of compact CNS myelin and mutations in the PLP gene can lead to severe dysmyelinating disease (Hudson et al. 1989). Mouse anti myelin proteolipid protein, clone plpc1 has proved a useful immunohistochemical tool for the study of central nervous system injury in patients with multiple sclerosis (Seewan et al. 2011, Huizinga et al. 2011) |
- Target Species
- Bovine
- Species Cross-Reactivity
-
Target Species Cross Reactivity Human Tenerife lizard (Gallotia galloti) - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Immunogen
- Synthetic peptide GRGTKF corresponding to C terminal region of myelin proteolipid protein.
- Approx. Protein Concentrations
- IgG concentration 1 mg/ml
- Fusion Partners
- Spleen cells from immunized BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry |  |
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| Immunofluorescence | |
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| Immunohistology - Frozen | |
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| Immunohistology - Paraffin | |
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| Western Blotting | |
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse IgG2a Negative Control | MCA929 | F | 100 Tests |
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| Description | Mouse IgG2a Negative Control | ||||||
References for Myelin Proteolipid Protein antibody
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J Neurosci. 30: 5958-67. -
Gilmore, C.P. et al. (2006) Spinal cord gray matter demyelination in multiple sclerosis-a novel pattern of residual plaque morphology.
Brain Pathol. 16: 202-8.
View The Latest Product References
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Mult Scler. 22 (10): 1306-14. -
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Mult Scler Relat Disord. 8: 11-8. -
Shakhbazau, A. et al. (2016) Demyelination induces transport of ribosome-containing vesicles from glia to axons: evidence from animal models and MS patient brains.
Mol Biol Rep. 43 (6): 495-507. -
Kilsdonk, I.D. et al. (2016) Increased cortical grey matter lesion detection in multiple sclerosis with 7 T MRI: a post-mortem verification study.
Brain. 139 (Pt 5): 1472-81. -
Dooves, S. et al. (2016) Astrocytes are central in the pathomechanisms of vanishing white matter.
J Clin Invest. 126 (4): 1512-24. -
Clarner, T. et al. (2015) CXCL10 triggers early microglial activation in the cuprizone model.
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Brain Behav Immun. 59: 103-17. -
Zimmermann, J. et al. (2018) IL-17A Promotes Granulocyte Infiltration, Myelin Loss, Microglia Activation, and Behavioral Deficits During Cuprizone-Induced Demyelination.
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Zendedel, A. et al. (2016) Regulatory effect of triiodothyronine on brain myelination and astrogliosis after cuprizone-induced demyelination in mice.
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Bihler, K. et al. (2017) Formyl Peptide Receptor 1-Mediated Glial Cell Activation in a Mouse Model of Cuprizone-Induced Demyelination.
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Acta Neuropathol Commun. 8 (1): 136. -
van Wageningen, T.A. et al. (2019) Regulation of microglial TMEM119 and P2RY12 immunoreactivity in multiple sclerosis white and grey matter lesions is dependent on their inflammatory environment.
Acta Neuropathol Commun. 7 (1): 206. -
Esser, S. et al. (2018) Toll-Like Receptor 2-Mediated Glial Cell Activation in a Mouse Model of Cuprizone-Induced Demyelination.
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de Jong C. et al. (2018) Galectin-4, a Negative Regulator of Oligodendrocyte Differentiation, Is Persistently Present in Axons and Microglia/Macrophages in Multiple Sclerosis Lesions.
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Yates, R.L. et al. (2021) The influence of HLA-DRB1*15 on the relationship between microglia and neurons in multiple sclerosis normal appearing cortical grey matter.
Brain Pathol. 2021: e13041. -
Tham, M. et al. (2021) Iron Heterogeneity in Early Active Multiple Sclerosis Lesions.
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Acta Neuropathol. 143 (2): 245-62. -
Miedema, A. et al. (2022) Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter.
Acta Neuropathol Commun. 10 (1): 8. -
Vanoevelen, J.M. et al. (2022) DTYMK is essential for genome integrity and neuronal survival.
Acta Neuropathol. 143 (2): 245-62. -
Cooze, B.J. et al. (2022) The association between neurodegeneration and local complement activation in the thalamus to progressive multiple sclerosis outcome.
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van den Bosch, A. et al. (2022) Neurofilament Light Chain Levels in Multiple Sclerosis Correlate With Lesions Containing Foamy Macrophages and With Acute Axonal Damage.
Neurol Neuroimmunol Neuroinflamm. 9 (3): e1154. -
Castillo-Rodriguez, M.L.A. et al. (2022) Astroglial and oligodendroglial markers in the cuprizone animal model for de- and remyelination.
Histochem Cell Biol. 158 (1): 15-38. -
Hardy, T.A. et al. (2022) The clinical spectrum of haemorrhagic CNS inflammatory demyelinating lesions.
Mult Scler. 28 (11): 1710-8. -
Yates, R.L. et al. (2022) The influence of HLA-DRB1*15 on the relationship between microglia and neurons in multiple sclerosis normal appearing cortical grey matter.
Brain Pathol. 32 (4): e13041. -
Miedema, S.S.M. et al. (2022) Distinct cell type-specific protein signatures in GRN and MAPT genetic subtypes of frontotemporal dementia.
Acta Neuropathol Commun. 10 (1): 100. -
Muñoz, U. et al. (2022) Main Role of Antibodies in Demyelination and Axonal Damage in Multiple Sclerosis.
Cell Mol Neurobiol. 42 (6): 1809-27. -
Valencia-Sanchez, C. et al. (2022) Cerebral Cortical Encephalitis in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.
Ann Neurol. Nov 13 [Epub ahead of print]. -
Baksmeier, C. et al. (2021) Modified recombinant human IgG1-Fc is superior to natural intravenous immunoglobulin at inhibiting immune-mediated demyelination.
Immunology. 164 (1): 90-105.
- Synonyms
- DM20
- PLP
- RRID
- AB_2237198
- UniProt
- P04116
- Entrez Gene
- PLP1
- GO Terms
- GO:0016021 integral to membrane
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