Folate Binding Protein antibody | SF55 (BGN/1210/55)

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Mouse anti Folate Binding Protein

Product Type
Monoclonal Antibody
Clone
SF55 (BGN/1210/55)
Isotype
IgG1
Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
0100-0528 E 0.2 mg
Mouse anti folate binding protein antibody, clone SF55, recognizes the folate receptor alpha, also known as folate binding protein (FBP) and Milk folate-binding protein. Folate receptor alpha is a 241 amino acid 30 kDa protein with a 19 amino acid signal peptide and a 7 amino acid c-terminal propeptide cleaved in the mature form. The folate receptor alpha has a high affinity for folate and several reduced folic acid derivatives and mediates the intracelullar delivery of 5 methyltetrahydrofolate. Membrane bound and soluble forms of a high affinity FBP have been found in kidney, placenta, serum, milk, and several cell lines.

Mouse anti folate binding protein antibody, clone SF55 can enhance STAT3 activation through binding to the folatereceptor alpha (Hansen et al. 2015).

Product Details

Target Species
Bovine
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.1%Sodium Azide (NaN3)
Immunogen
Folate binding protein from bovine milk.
Approx. Protein Concentrations
1.0 mg/ml

Storage Information

Storage
Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life
18 months from date of despatch.

More Information

UniProt
P02702 Related reagents
Entrez Gene
FBP1 Related reagents
GO Terms
GO:0004872 receptor activity
GO:0005542 folic acid binding
Regulatory
For research purposes only

Applications of Folate Binding Protein antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.

Product Specific References

References for Folate Binding Protein antibody

  1. Hansen, M.F. et al. (2015) Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha.
    Cell Signal. 27 (7): 1356-68.

Further Reading

  1. Henderson, G.B. (1990) Folate-binding proteins.
    Annu Rev Nutr. 10: 319-35.
  2. Jones, M.L. & Nixon, P.F. (2002) Tetrahydrofolates are greatly stabilized by binding to bovine milk folate-binding protein.
    J Nutr. 132 (9): 2690-4.