Mouse anti folate binding protein antibody, clone SF55,
recognizes the folate receptor alpha, also known as folate binding protein (FBP) and Milk folate-binding protein. Folate receptor alpha is a 241 amino acid 30 kDa protein with a 19 amino acid signal peptide and a 7 amino acid c-terminal propeptide cleaved in the mature form. The folate receptor alpha has a high affinity for folate and several reduced folic acid derivatives and mediates the intracelullar delivery of 5 methyltetrahydrofolate. Membrane bound and soluble forms of a high affinity FBP have been found in kidney, placenta, serum, milk, and several cell lines.
Mouse anti folate binding protein antibody, clone SF55 can enhance STAT3 activation through binding to the folatereceptor alpha (Hansen et al. 2015
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from ascites
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- Folate binding protein from bovine milk.
- Approx. Protein Concentrations
- 1.0 mg/ml
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
folic acid binding
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Folate Binding Protein antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
Copyright © 2020 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
Product Specific References
References for Folate Binding Protein antibody
Hansen, M.F. et al. (2015) Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha.
Cell Signal. 27 (7): 1356-68.
Henderson, G.B. (1990) Folate-binding proteins.
Annu Rev Nutr. 10: 319-35.
Jones, M.L. & Nixon, P.F. (2002) Tetrahydrofolates are greatly stabilized by binding to bovine milk folate-binding protein.
J Nutr. 132 (9): 2690-4.