Somatostatin Receptor 4 Antibody | sstr4

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  • Mouse anti Human Somatostatin Receptor 4
(Rated 0.0 out of 5 based on 0 customer reviews)
  • Product Type
    Monoclonal Antibody
  • Clone
    sstr4
  • Isotype
    IgG2a
1 Formats Available
    Product CodeApplicationsDatasheetMSDSPack SizeList PriceQuantity
    MCA5922Pdatasheet pdfdatasheet pdf0.2 mg
    MCA5922
    Summary
    Secondary Antibodies
    Negative Isotype Controls
    Useful Reagents
    Positive Controls
    Histology Controls
    More Images
    References
    Reviews
    -
    • Mouse anti Human Somatostatin Receptor 4 antibody, clone sstr4 recognizes human somatostatin receptor 4, a 388 amino acid multi pass transmembrane glycoprotein freceptor for somatostatin-14. Somatostatin (SST) is a peptide hormone with wide ranging inhibitory effects on hormone secretion and cell proliferation. It is produced as a large preproSST precursor molecule that is cleaved to yield one of two active forms of the peptide: a 14 amino acid peptide (SST-14), or a 28 amino acid peptide (SST-28). The inhibitory effects of SST on hormone release and cell growth have made them candidates for the treatment of cancer and neuroendocrine disorders. Natural SSTs have very short half-lives, which led to the development of more stable synthetic derivatives, such as octreotide and lanreotide, both in common clinical use.

      The effects of SST are mediated via five distinct SST receptors (SSTRs). The receptors have similar affinities for natural SST-14 and SST-28, but there are marked differences in affinities towards the synthetic analogues. Somatostatin receptors are expressed by various tissues, notably neuronal, endocrine, gastrointestinal and immune cells, as well as certain tumours, with tumours often expressing more than one subtype in different combinations.

      Mouse anti Human Somatostatin Receptor 4 antibody, clone sstr4 specifically recognises SSTR type 4, but none of the other SSTR subtypes. Bio-Rad also has antibodies to SSTR subtypes 1, 3 and 5 (MCA5924, MCA5921, MCA5923) available.
    • Intended Use
    • Target Species
      Human
    • Product Form
      Purified IgG - liquid
    • Reconstitution
    • Preparation
    • Preservative Stabilisers
      0.09% Sodium Azide (NaN3)
    • Immunogen
      Synthetic peptide, sequence CQQEALQPEPGRKRIPLT.
    • Purity
    • Approx. Protein Concentrations
      IgG concentration 1mg/ml
    • Reagents In The Kit
    • Preparing The Antibody
    • Test Principle
    • Buffer Solution
      Phosphate buffered saline
    • Storage
      Store at +4oC or at -20oC if preferred.
      Storage in frost-free freezers is not recommended.
      This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
    • Shelf Life
      18 months from date of despatch.
    • GO Terms
      G-protein signaling, coupled to cyclic nucleotide second messenger
      integral to plasma membrane
      negative regulation of cell proliferation
      somatostatin receptor activity
    • UniProt
    • Entrez Gene
    • Acknowledgements
    • Regulatory
      For research purposes only
    • This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

    • Application NameYesNoMin DilutionMax Dilution
      Immunohistology - Paraffin
      Western Blotting

    • Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
    • Technical Advice
    • Recommended Protocol
    • ELISA
    • Immunohistology
    • Histology Positive Control Tissue
      Human lung tissue
    • Immunofluorescence
    • Western Blotting
    • Instructions For Use

    Additional Somatostatin Receptor 4 Antibody Formats

    Formats Clone Applications Sizes available
    Somatostatin Receptor 4 Antibody : Purified sstr4 P 0.2 mg
    • Copyright © 2016 Bio-Rad

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      Recommended Negative Isotype Control

        Useful Reagents

          Recommended Positive Controls

            Histology Controls

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              References

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