Influenza A Nucleoprotein antibody | AA5H
Mouse anti Influenza A Nucleoprotein antibody, clone AA5H (MCA400) used for the detection of viral nucleoproitein in influenza infected HEK-293 cells by western blotting.
Image caption:
Forced expression of influenza viral proteins does not result in impaired IFNβ-induced STAT1 and STAT2 phosphorylation. HEK293 cells were transfected with 500 ng plasmid DNA for expression of viral NP, M, NS, (A) PA, PB1 and PB2 (C) genes (see Table 1 for accession numbers of viral genes) using L2000 according to manufacturer's instructions. Note that the Pol II constructs in use also give rise to expression of second reading frames in the NS, M and PB1 genes (NS2, M2, PB1-F2). 48 h post transfection cells were stimulated with human IFNβ (500 U/ml) for 15 minutes. Total protein lysates were subjected to Western blot analysis using anti-phospho-STAT1, anti-phospho-STAT2, anti-STAT1 antibodies. Expression of influenza viral proteins was monitored with antibodies against NP, M1, NS1, PA, PB1 or PB2. (E) HEK293 cells were infected with the human influenza virus PR8 (H1N1) (MOI = 5) for the indicated time points and were subsequently stimulated for 15 min with either human IFNβ at a concentration of 100 U/ml. Cell lysates were subjected to Western blots as described. (B, D, F) Quantification of relative pSTAT1 and pSTAT2 band intensities in A, C and E using AIDA software and 2D densitometry (Fuji).
From: Pauli E-K, Schmolke M, Wolff T, Viemann D, Roth J, Bode JG, et al. (2008)
Influenza A Virus Inhibits Type I IFN Signaling via NF-κB-Dependent Induction of SOCS-3 Expression.
PLoS Pathog 4(11): e1000196.
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.
Mouse anti Influenza A Nucleoprotein antibody, clone AA5H (MCA400) used for the identification of influenza viral nucleoprotein in infected cell lysates by western botting.
Image caption:
Replication and IFN-β induction by human and avian H5N1 strains in human cells. (A, B) A549 cells were infected at a multiplicity of 0.01 (A) or 1 (B) with the highly-pathogenic human H5N1 IAV isolates A/Hong Kong/156/1997 (HK/97) and A/Thailand/1 (KAN-1)/2004 (Thai/04), the avian H5N1 strains A/chicken/Indonesia/R132/2004 (Ch/Ind), A/duck/Vietnam/TG24-O1/2005 (Duck/VN) and A/common buzzard/Berlin/1/2006 (Buzz/Bln) as well as with the prototypic seasonal A/Panama/2007/99 (Pan/99) H3N2 virus and its mutant variant with a deleted NS1 gene (Pan-delNS1; shown only in panel A). Supernatant of infected cell cultures was sampled at the indicated time points and viral titers were determined by plaque assay. Mean data+SEM of at least three independent experiments is shown. (C) Immunoblot analysis of lysates from A549 cells infected at MOI = 1 using a viral NP-specific antibody at the indicated time points post infection (p.i.). Relative intensities of NP bands normalized to actin controls are depicted in comparison to Thai/04, which was arbitrarily set as 100%. (D, E) Concentrations of IFN-β in cell culture supernatants of A549 cells infected with the indicated viruses at low (MOI = 0,01, panel D) or high multiplicity (MOI = 1, panel E) determined via ELISA at 24 and 48 hpi (D) or at 16 hpi (E). Mean data of at least three independent experiments +/– SEM is shown. Symbols indicate significant differences between given results with p<0.05 (*), p<0.01 (**), or p<0.001(***), respectively, as determined by unpaired two-tailed t-tests.
From: Matthaei M, Budt M, Wolff T (2013)
Highly Pathogenic H5N1 Influenza A Virus Strains Provoke Heterogeneous IFN-α/β Responses That Distinctively Affect Viral Propagation in Human Cells.
PLoS ONE 8(2): e56659.
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.
Mouse anti Influenza A Nucleoprotein antibody, clone AA5H (MCA400) used for the identification of influenza viral nucleoprotein in infected cell lysates.
Image caption:
Published customer image:
Mouse anti Influenza A Nucleoprotein antibody, clone AA5H used for the identification of influenza viral nucleoprotein in infected cell lysates.
Image caption:
H5N1 NS1 proteins inhibit the induction of type I IFN in human cells. (A) IFN-β concentrations of supernatants sampled from A549 cell cultures infected with the Pan99 WT and different NS reassortant viruses (H3N2) (MOI = 0.01) at 24 and 48 hrs p.i., (N≥2+/–SEM). (B) Human 293T cells were co-transfected with plasmids expressing the H5N1- or Pan/99 (H3N2)-derived NS segments or empty vector, the human IFN-β promoter reporter plasmid p125-Luc and pRL-TK-Luc to control for transfection efficiency. Subsequently, cells were infected for 16 h with Pan-delNS1 to stimulate the IFN-β promoter before luciferase reporter activity was determined in cell lysates. IFN-β promoter activation in infected cells is shown as x-fold stimulation of firefly luciferase activity compared to transfected and mock infected cells. Mean data of three independent experiments is shown +/– SD. (C) Immunblot detection of viral NP after Pan-delNS1 (H3N2) infection confirmed equal stimulation of the transfected cells analyzed in panel B.
From: Matthaei M, Budt M, Wolff T (2013)
Highly Pathogenic H5N1 Influenza A Virus Strains Provoke Heterogeneous IFN-α/β Responses That Distinctively Affect Viral Propagation in Human Cells.
PLoS ONE 8(2): e56659.
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.
Mouse anti influenza A nucleoprotein antibody, clone AA5H (MCA400) used for the detection of influenza virus in avian oviduct sections by immunofluorescence.
Image caption:
Influenza A viruses (IAV)-antigen detection and β-tubulin staining of MOC of Pekin duck (Du) and turkey (Tu) (Experiments 1 and 3). MOC were infected with H9N2 [104 focus forming assay (FFU)/MOC] and collected at 12, 24, and 48 hours post infection (hpi). MOC sections were stained for IAV-nucleoprotein (FITC, green), β-tubulin (Cy3, red), and cell nuclei (DAPI, blue) and analyzed by fluorescence microscopy. Presented is a merge of three colors: red, green, and blue. IAV nucleoprotein was detected with mouse monoclonal antibodies which were visualized by secondary Alexa fluor® 488 goat anti-mouse antibodies. Negative virus-negative controls consist of non-infected MOC-Ch. A representative picture of each species is shown.
From: Sid H, Hartmann S, Winter C, Rautenschlein S.
Interaction of Influenza A Viruses with Oviduct Explants of Different Avian Species.
Front Microbiol. 2017 Jul 20;8:1338. doi: 10.3389/fmicb.2017.01338.
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.
Mouse anti influenza A nucleoprotein antibody, clone AA5H (MCA400) used for the detection of influenza virus in avian oviduct sections by immunofluorescence.
Image caption:
Influenza A viruses (IAV)-antigen detection and β-tubulin staining of MOC of Pekin duck (Du) and turkey (Tu) (Experiments 1 and 3). MOC were infected with pH1N1 [104 focus forming assay (FFU)/MOC] and collected at 12, 24, and 48 hours post infection (hpi). MOC sections were stained for IAV-nucleoprotein (FITC, green), β-tubulin (Cy3, red), and cell nuclei (DAPI, blue) and analyzed by fluorescence microscopy. Presented is a merge of three colors: red, green, and blue. IAV nucleoprotein was detected with mouse monoclonal antibodies which were visualized by secondary Alexa fluor® 488 goat anti-mouse antibodies. Negative virus-negative controls consist of non-infected MOC-Ch. A representative picture of each species is shown.
From: Sid H, Hartmann S, Winter C, Rautenschlein S.
Interaction of Influenza A Viruses with Oviduct Explants of Different Avian Species.
Front Microbiol. 2017 Jul 20;8:1338. doi: 10.3389/fmicb.2017.01338.
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.
Mouse anti influenza A nucleoprotein antibody, clone AA5H (MCA400) used for the detection of influenza virus in avian oviduct sections by immunofluorescence.
Image caption:
Influenza A viruses (IAV)-antigen detection and β-tubulin staining of MOC of Pekin duck (Du) and turkey (Tu) (Experiments 1 and 3). MOC were infected with H6N8 [104 focus forming assay (FFU)/MOC] and collected at 12, 24, and 48 hours post infection (hpi). MOC sections were stained for IAV-nucleoprotein (FITC, green), β-tubulin (Cy3, red), and cell nuclei (DAPI, blue) and analyzed by fluorescence microscopy. Presented is a merge of three colors: red, green, and blue. IAV nucleoprotein was detected with mouse monoclonal antibodies which were visualized by secondary Alexa fluor® 488 goat anti-mouse antibodies. Negative virus-negative controls consist of non-infected MOC-Ch. A representative picture of each species is shown.
From: Sid H, Hartmann S, Winter C, Rautenschlein S.
Interaction of Influenza A Viruses with Oviduct Explants of Different Avian Species.
Front Microbiol. 2017 Jul 20;8:1338. doi: 10.3389/fmicb.2017.01338.
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.
Mouse anti Influenza A nucleoprotein antibody, clone AA5H (MCA400) used to demonstrate the presence of viral antigen in chicken tissues by immunohistochemistry on formalin fixed, paraffin embedded tissue sections.
Image caption:
Histological lesions and immunohistochemical detection of viral antigen in lungs, brain, and liver of chicken infected with A(H5N8) HPAI virus; viral antigen staining in red. Note: (a) erythrocytes in the parabronchial lumen and atria of the lung. Bar = 50 μm. (b) The same. Bar = 20 μm. (c) Viral antigen in the alveolar macrophages and alveolar cells. Bar = 20 μm.
From: Prokopyeva EA, Zinserling VA, Bae YC, Kwon Y, Kurskaya OG, Sobolev IA, Kozhin PM, Komissarov A, Fadeev A, Petrov V, Shestopalov AM, Sharshov KA.
Pathology of A(H5N8) (Clade 2.3.4.4) Virus in Experimentally Infected Chickens and Mice.
Interdiscip Perspect Infect Dis. 2019 Jul 4;2019:4124865.
doi: 10.1155/2019/4124865.
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.
Mouse anti Influenza A nucleoprotein antibody, clone AA5H (MCA400) used to demonstrate the presence of viral antigen in chicken tissues by immunohistochemistry on formalin fixed, paraffin embedded tissue sections.
Image caption:
Histological lesions and immunohistochemical detection of viral antigen in lungs, brain, and liver of chicken infected with A(H5N8) HPAI virus; viral antigen staining in red. (d) Venous and capillary hyperemia of the brain. Bar = 100 μm. (e) Local area of brain infiltration. Bar = 20 μm. (f) Many AIV antigens are found in neurons (insert with magnification x1000) and glial cells. Bar = 20 μm.
From: Prokopyeva EA, Zinserling VA, Bae YC, Kwon Y, Kurskaya OG, Sobolev IA, Kozhin PM, Komissarov A, Fadeev A, Petrov V, Shestopalov AM, Sharshov KA.
Pathology of A(H5N8) (Clade 2.3.4.4) Virus in Experimentally Infected Chickens and Mice.
Interdiscip Perspect Infect Dis. 2019 Jul 4;2019:4124865.
doi: 10.1155/2019/4124865.
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.
Mouse anti Influenza A nucleoprotein antibody, clone AA5H (MCA400) used to demonstrate the presence of viral antigen in chicken tissues by immunohistochemistry on formalin fixed, paraffin embedded tissue sections.
Image caption:
Histological lesions and immunohistochemical detection of viral antigen in lungs, brain, and liver of chicken infected with A(H5N8) HPAI virus; viral antigen staining in red. (g) The venous and capillary hyperemia in liver. Bar = 20 μm. (h) The dystrophic changes at a vast area of liver parenchyma; the predominance of active macrophages; and a large number of mast cells, basophils, and eosinophils. Bar = 100 μm. (i) Viral antigen in the Kupffer cell (insert with magnification x1000) and in hepatocytes (bar = 20 μm). Insert demonstrates viral antigen presence in hepatocyte. Magnification x1000.
From: Prokopyeva EA, Zinserling VA, Bae YC, Kwon Y, Kurskaya OG, Sobolev IA, Kozhin PM, Komissarov A, Fadeev A, Petrov V, Shestopalov AM, Sharshov KA.
Pathology of A(H5N8) (Clade 2.3.4.4) Virus in Experimentally Infected Chickens and Mice.
Interdiscip Perspect Infect Dis. 2019 Jul 4;2019:4124865.
doi: 10.1155/2019/4124865.
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.
Mouse anti Influenza A nucleoprotein antibody, clone AA5H (MCA400) used to demonstrate the presence of viral antigen in chicken tissues by immunohistochemistry on formalin fixed, paraffin embedded tissue sections.
Image caption:
Histological lesions and immunohistochemical detection of viral antigen in heart, intestine, kidneys, and spleen of chicken infected with HPAI A(H5N8) virus; viral antigen staining in red. Note: (a) the lymphohistiocytic myocarditis. Bar = 20 μm. (b) Viral antigen in myocytes. Bar = 20 μm.
HE: hematoxylin-and-eosin staining; IHC: immunohistochemical staining.
From: Prokopyeva EA, Zinserling VA, Bae YC, Kwon Y, Kurskaya OG, Sobolev IA, Kozhin PM, Komissarov A, Fadeev A, Petrov V, Shestopalov AM, Sharshov KA.
Pathology of A(H5N8) (Clade 2.3.4.4) Virus in Experimentally Infected Chickens and Mice.
Interdiscip Perspect Infect Dis. 2019 Jul 4;2019:4124865.
doi: 10.1155/2019/4124865.
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.
Mouse anti Influenza A nucleoprotein antibody, clone AA5H (MCA400) used to demonstrate the presence of viral antigen in chicken tissues by immunohistochemistry on formalin fixed, paraffin embedded tissue sections.
Image caption:
Histological lesions and immunohistochemical detection of viral antigen in heart, intestine, kidneys, and spleen of chicken infected with HPAI A(H5N8) virus; viral antigen staining in red. (c) Intensive mononuclear infltration of the small intestine; desquamation of epithelium. Bar = 20 μm. (d) Viral antigen in epithelial cells. Bar = 20 μm.
HE: hematoxylin-and-eosin staining; IHC: immunohistochemical staining.
From: Prokopyeva EA, Zinserling VA, Bae YC, Kwon Y, Kurskaya OG, Sobolev IA, Kozhin PM, Komissarov A, Fadeev A, Petrov V, Shestopalov AM, Sharshov KA.
Pathology of A(H5N8) (Clade 2.3.4.4) Virus in Experimentally Infected Chickens and Mice.
Interdiscip Perspect Infect Dis. 2019 Jul 4;2019:4124865.
doi: 10.1155/2019/4124865.
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.
Mouse anti Influenza A nucleoprotein antibody, clone AA5H (MCA400) used to demonstrate the presence of viral antigen in chicken tissues by immunohistochemistry on formalin fixed, paraffin embedded tissue sections.
Image caption:
Histological lesions and immunohistochemical detection of viral antigen in heart, intestine, kidneys, and spleen of chicken infected with HPAI A(H5N8) virus; viral antigen staining in red. (c) Intensive mononuclear infltration of the small intestine; desquamation of epithelium. Bar = 20 μm. (d) Viral antigen in epithelial cells. Bar = 20 μm.
HE: hematoxylin-and-eosin staining; IHC: immunohistochemical staining.
From: Prokopyeva EA, Zinserling VA, Bae YC, Kwon Y, Kurskaya OG, Sobolev IA, Kozhin PM, Komissarov A, Fadeev A, Petrov V, Shestopalov AM, Sharshov KA.
Pathology of A(H5N8) (Clade 2.3.4.4) Virus in Experimentally Infected Chickens and Mice.
Interdiscip Perspect Infect Dis. 2019 Jul 4;2019:4124865.
doi: 10.1155/2019/4124865.
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.
Mouse anti Influenza A nucleoprotein antibody, clone AA5H (MCA400) used to demonstrate the presence of viral antigen in chicken tissues by immunohistochemistry on formalin fixed, paraffin embedded tissue sections.
Image caption:
Histological lesions and immunohistochemical detection of viral antigen in heart, intestine, kidneys, and spleen of chicken infected with HPAI A(H5N8) virus; viral antigen staining in red. (g) Local area of necrosis in spleen. Bar = 20 μm. (h) Viral antigen in spleen macrophages. Bar = 20 μm.
HE: hematoxylin-and-eosin staining; IHC: immunohistochemical staining.
From: Prokopyeva EA, Zinserling VA, Bae YC, Kwon Y, Kurskaya OG, Sobolev IA, Kozhin PM, Komissarov A, Fadeev A, Petrov V, Shestopalov AM, Sharshov KA.
Pathology of A(H5N8) (Clade 2.3.4.4) Virus in Experimentally Infected Chickens and Mice.
Interdiscip Perspect Infect Dis. 2019 Jul 4;2019:4124865.
doi: 10.1155/2019/4124865.
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.
Mouse anti Influenza A Nucleoprotein antibody, clone AA5H (MCA400) used for the detection of viral protein in a range of organs from an influenza infected patient using immunohistochemistry on formalin fixed, paraffin embedded tissue sections.
Image caption:
The results of IHC stain with antibody against NP. Positive stain seen with diaminobenzidine (brown; Dako). Slides counterstained with haematoxylin. (A) Positive stain presented in pneumocytes of lung (arrow). (B) Endotheliocyte of aortopulmonary vessel (arrow). (C) Positive stain in nuclei and cytoplasm of axillary lymphoid-node (arrow). (D) Positive stain in lymphocytes of spleen (arrow). (E) Positive stain in cytoplasm of neuron and gliocyte from cerebral cortex (arrows). (F) Positive stain in nuclei and cytoplasm of intestine mucosa (arrows). (G) Positive stain in nuclei of mononuclear-like cells (arrows) with morphological features of macrophages from liver. (H) Positive stain in cytoplasm and nuclei of endotheliocytes of renal contex. (I) Positive stain in nuclei and cytoplasm of epithelial cells from ureter (arrow). Original magnifications: (A) ×20, (B–E) ×40, (F–G) ×20, (H–I) ×40.
From: Gao R, Dong L, Dong J, Wen L, Zhang Y, Yu H, et al. (2010)
A Systematic Molecular Pathology Study of a Laboratory Confirmed H5N1 Human Case.
PLoS ONE 5(10): e13315.
This image is from an open access article distributed under the terms of the Creative Commons Attribution License.
Mouse anti Influenza A Nucleoprotein antibody, clone AA5H (MCA400) used to demonstrate viral NP in host cells by immunofluorescence.
Image caption:
Interferon-independent LE/L cholesterol accumulation impairs early IAV infection. (A) A549-WT cells transfected with GFP, AnxA6-GFP, or AnxA6-GFP together with YFP-NPC1 were infected with IAV (PR8M; MOI of 5, 4 h). Cells were stained with anti-NP antibodies, and nuclei were labeled with DAPI. Bar, 20 μumbers of transfected cells with NP-positive nuclei were determined from 150 transfected cells per condition from at least three independent experiments. Data are expressed as mean percentages ± P ≤; ***, P ≤1; ns, not significant (one-way ANOVA with Tukey’s multiple-comparison test).
From: Kühnl A, Musiol A, Heitzig N, Johnson DE, Ehrhardt C, Grewal T, Gerke V, Ludwig S, Rescher U.
Late Endosomal/Lysosomal Cholesterol Accumulation Is a Host Cell-Protective Mechanism Inhibiting Endosomal Escape of Influenza A Virus.
mBio. 2018 Jul 24;9(4):e01345-18.
doi: 10.1128/mBio.01345-18.
This image is from an open access article distributed under terms of a Creative Commons Attribution License.
Mouse anti Influenza A Nucleoprotein
- Product Type
- Monoclonal Antibody
- Clone
- AA5H
- Isotype
- IgG2a
- Specificity
- Influenza A Nucleoprotein
Antibody Quality and Performance Guarantee
| Mouse anti Influenza A Nucleoprotein antibody, clone AA5H recognizes an epitope within Influenza virus A nucleoprotein. Mouse anti Influenza A Nucleoprotein antibody, clone AA5H can be used in influenza A IFA typing in conjunction with MCA401 (clone GA2B). |
- Target Species
- Viral
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Immunogen
- Influenza A / Puerto Rico / 8 / 34 (H1N1) and A/Bangkok / 1 / 79 (H3N2) viruses.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from BALB/c mice were fused with cells of the P3 Ag8.653 mouse myeloma cell line.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Immunofluorescence |  |
||
| Immunohistology - Paraffin | |
||
| Western Blotting | |
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
References for Influenza A Nucleoprotein antibody
-
Herold, S. et al. (2006) Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion molecules.
J Immunol. 177 (3): 1817-24. -
Thompson, C.I. et al. (2006) Infection of human airway epithelium by human and avian strains of influenza a virus.
J Virol. 80: 8060-8. -
Ehrhardt, C. et al. (2007) Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses.
J Virol. 81: 3058-67. -
Ehrhardt, C. et al. (2007) Activation of phosphatidylinositol 3-kinase signaling by the nonstructural NS1 protein is not conserved among type A and B influenza viruses.
J Virol. 81: 12097-100. -
Ehrhardt, C. et al. (2007) A polyphenol rich plant extract, CYSTUS052, exerts anti influenza virus activity in cell culture without toxic side effects or the tendency to induce viral resistance.
Antiviral Res. 76: 38-47. -
Pauli, E.K. et al. (2008) Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression.
PLoS Pathog. 4(11): e1000196. -
Nencioni, L. et al. (2009) Bcl-2 expression and p38MAPK activity in cells infected with influenza A virus: impact on virally induced apoptosis and viral replication.
J Biol Chem. 284: 16004-15. -
Jamali, A. et al. (2010) A DNA vaccine-encoded nucleoprotein of influenza virus fails to induce cellular immune responses in a diabetic mouse model.
Clin Vaccine Immunol. 17: 683-7.
View The Latest Product References
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Seitz, C. et al. (2010) High yields of influenza A virus in Madin-Darby canine kidney cells are promoted by an insufficient interferon-induced antiviral state.
J Gen Virol. 91: 1754-63. -
Luig, C. et al. (2010) MAP kinase-activated protein kinases 2 and 3 are required for influenza A virus propagation and act via inhibition of PKR.
FASEB J. 24: 4068-77. -
Shu, Y. et al. (2010) Avian influenza A(H5N1) viruses can directly infect and replicate in human gut tissues.
J Infect Dis. 201: 1173-7. -
Gao, R. et al. (2010) A systematic molecular pathology study of a laboratory confirmed H5N1 human case.
PLoS One. 5: e13315. -
Matarrese, P. et al. (2011) Pepstatin A alters host cell autophagic machinery and leads to a decrease in influenza A virus production.
J Cell Physiol. 226 (12): 3368-77. -
Gabay, C. et al. (2011) Impact of synthetic and biologic disease-modifying antirheumatic drugs on antibody responses to the AS03-adjuvanted pandemic influenza vaccine: a prospective, open-label, parallel-cohort, single-center study.
Arthritis Rheum. 63 (6): 1486-96. -
Hrincius, E.R. et al. (2011) Phosphatidylinositol-3-kinase (PI3K) is activated by influenza virus vRNA via the pathogen pattern receptor Rig-I to promote efficient type I interferon production.
Cell Microbiol. 13: 1907-19. -
Calmy, A. et al. (2012) Strong serological responses and HIV RNA increase following AS03-adjuvanted pandemic immunization in HIV-infected patients.
HIV Med. 13 (4): 207-18. -
Koerner, I. et al. (2012) Altered receptor specificity and fusion activity of the haemagglutinin contribute to high virulence of a mouse-adapted influenza A virus.
J Gen Virol. 93 (Pt 5): 970-9. -
Hassan, I.H. et al. (2012) Influenza A viral replication is blocked by inhibition of the inositol-requiring enzyme 1 (IRE1) stress pathway.
J Biol Chem. 287 (7): 4679-89. -
Matthaei M et al. (2013) Highly pathogenic H5N1 influenza A virus strains provoke heterogeneous IFN-α/β responses that distinctively affect viral propagation in human cells.
PLoS One. 8 (2): e56659. -
Dick, A. et al. (2015) Role of nucleotide binding and GTPase domain dimerization in dynamin-like myxovirus resistance protein A for GTPase activation and antiviral activity.
J Biol Chem. 290 (20): 12779-92. -
Shoji, M. et al. (2015) Bakuchiol Is a Phenolic Isoprenoid with Novel Enantiomer-selective Anti-influenza A Virus Activity Involving Nrf2 Activation.
J Biol Chem. 290 (46): 28001-17. -
Wörmann, X. et al. (2016) Genetic characterization of an adapted pandemic 2009 H1N1 influenza virus that reveals improved replication rates in human lung epithelial cells.
Virology. 492: 118-29. -
Kim HR et al. (2016) Ostrich ( Struthio camelus ) Infected with H5N8 Highly Pathogenic Avian Influenza Virus in South Korea in 2014.
Avian Dis. 60 (2): 535-9. -
Thulasi Raman, S.N. et al. (2016) DDX3 Interacts with Influenza A Virus NS1 and NP Proteins and Exerts Antiviral Function through Regulation of Stress Granule Formation.
J Virol. 90 (7): 3661-75. -
Sadewasser, A. et al. (2017) Quantitative Proteomic Approach Identifies Vpr Binding Protein as Novel Host Factor Supporting Influenza A Virus Infections in Human Cells.
Mol Cell Proteomics. 16 (5): 728-42. -
Sid, H. et al. (2017) Interaction of Influenza A Viruses with Oviduct Explants of Different Avian Species.
Front Microbiol. 8: 1338. -
Youchan, B. et al. (2018) Pathological lesions and antigen localization in chicken, ducks and Japanese quail naturally infected by novel highly pathogenic avian influenza (H5N6), Korea, 2016
J Prev Vet Med. 42 (3): 91-8. -
Mayr, J. et al. (2018) Unravelling the Role of O-glycans in Influenza A Virus Infection.
Sci Rep. 8 (1): 16382. -
Prokopyeva, E.A. et al. (2019) Pathology of A(H5N8) (Clade 2.3.4.4) Virus in Experimentally Infected Chickens and Mice.
Interdiscip Perspect Infect Dis. 2019: 4124865. -
MacKerracher, A. et al. (2022) PLGA particle vaccination elicits resident memory CD8 T cells protecting from tumors and infection.
Eur J Pharm Sci. : 106209. -
Kühnl, A. et al. (2018) Late Endosomal/Lysosomal Cholesterol Accumulation Is a Host Cell-Protective Mechanism Inhibiting Endosomal Escape of Influenza A Virus.
mBio. 9 (4): e01345-18. -
Forbester, J.L. et al. (2020) IRF5 Promotes Influenza Virus-Induced Inflammatory Responses in Human Induced Pluripotent Stem Cell-Derived Myeloid Cells and Murine Models.
J Virol. 94 (9): e00121-20.
- RRID
- AB_2151884
MCA400
158183
165120
180725
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