Influenza A Matrix Protein antibody | GA2B
Mouse anti Influenza A matrix protein 1 antibody, clone GA2B can be used in influenza A IFA typing in conjunction with Mouse anti Influenza A matrix protein, clone AA5H.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant.
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Influenza A / Puerto Rico / 8 / 34 (H1N1) and A/Bangkok / 1 / 79 (H3N2) viruses.
- >90% IgG content as established by SDS PAGE
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the P3 Ag8.653 mouse myeloma cell line.
- This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
- GO:0005886 plasma membrane
- GO:0003723 RNA binding
- GO:0005829 cytosol
- GO:0005198 structural molecule activity
- GO:0005654 nucleoplasm
- GO:0019064 viral envelope fusion with host membrane
- GO:0019061 uncoating of virus
- GO:0019065 receptor-mediated endocytosis of virus by host
- GO:0019070 viral genome maturation
- GO:0019072 viral genome packaging
- GO:0019076 release of virus from host
- GO:0019083 viral transcription
- GO:0030666 endocytic vesicle membrane
- GO:0030683 evasion by virus of host immune response
- GO:0031904 endosome lumen
- GO:0042025 host cell nucleus
- GO:0046796 viral genome transport in host cell
- GO:0055036 virion membrane
- GO:0016020 membrane
- For research purposes only
Applications of Influenza A Matrix Protein antibody
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Paraffin|
Secondary Antibodies Available
Product Specific References
References for Influenza A Matrix Protein antibody
Latham, T. & Galarza, J.M. (2001) Formation of wild-type and chimeric influenza virus-like particles following simultaneous expression of only four structural proteins.
J Virol. 75 (13): 6154-65.
Zhirnov, O.P. & Klenk, H.D. (1997) Histones as a target for influenza virus matrix protein M1.
Virology. 235 (2): 302-10.
Viemann, D. et al. (2011) H5N1 virus activates signaling pathways in human endothelial cells resulting in a specific imbalanced inflammatory response.
J Immunol. 186 (1): 164-73.
Yamamoto, Y. et al. (2008) Avian influenza virus (H5N1) replication in feathers of domestic waterfowl.
Emerg Infect Dis. 14: 149-51.
Doucet, J.D. et al. (2011) Endogenously expressed matrix protein M1 and nucleoprotein of influenza A are efficiently presented by class I and class II major histocompatibility complexes.
J Gen Virol. 92 (Pt 5): 1162-71.
Tanimura N et al. (2006) Pathology of fatal highly pathogenic H5N1 avian influenza virus infection in large-billed crows (Corvus macrorhynchos) during the 2004 outbreak in Japan.
Vet Pathol. 43 (4): 500-9.
Kirkeby, S. et al. (2009) Infection with human H1N1 influenza virus affects the expression of sialic acids of metaplastic mucous cells in the ferret airways.
Virus Res. 144: 225-32.
Pauli, E.K. et al. (2008) Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression.
PLoS Pathog. 4(11): e1000196.
Eierhoff, T. et al. (2010) The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells.
PLoS Pathog. 6. pii: e1001099.
Wang, D. et al. (2010) The lack of an inherent membrane targeting signal is responsible for the failure of the matrix (M1) protein of influenza A virus to bud into virus-like particles.
J Virol. 84: 4673-81.
Kang, S.M. et al. (2009) Induction of long-term protective immune responses by influenza H5N1 virus-like particles.
PLoS One. 4: e4667.
Luig, C. et al. (2010) MAP kinase-activated protein kinases 2 and 3 are required for influenza A virus propagation and act via inhibition of PKR.
FASEB J. 24: 4068-77.
Schmolke, M. et al. (2009) Essential impact of NF-kappaB signaling on the H5N1 influenza A virus-induced transcriptome.
J Immunol. 183: 5180-9.
Reinhardt, J. and Wolff, T. (2000) The influenza A virus M1 protein interacts with the cellular receptor of activated C kinase (RACK) 1 and can be phosphorylated by protein kinase C.
Vet Microbiol. 74: 87-100.
Das, S.C. et al. (2012) The Highly Conserved Arginine Residues at Positions 76 through 78 of Influenza A Virus Matrix Protein M1 Play an Important Role in Viral Replication by Affecting the Intracellular Localization of M1.
J Virol. 86: 1522-30.
Liu, Y.V. et al. (2011) Chimeric severe acute respiratory syndrome coronavirus (SARS-CoV) S glycoprotein and influenza matrix 1 efficiently form virus-like particles (VLPs) that protect mice against challenge with SARS-CoV.
Vaccine. 29: 6606-13.
Moncorgé, O. et al. (2013) Investigation of influenza virus polymerase activity in pig cells.
J Virol. 87 (1): 384-94.
Khaperskyy, D.A. et al. (2012) Influenza A virus inhibits cytoplasmic stress granule formation.
FASEB J. 26: 1629-39.
Friesenhagen, J. et al. (2012) Highly pathogenic avian influenza viruses inhibit effective immune responses of human blood-derived macrophages.
J Leukoc Biol. 92: 11-20.
Londrigan, S.L. et al. (2015) Infection of Mouse Macrophages by Seasonal Influenza Viruses Can Be Restricted at the Level of Virus Entry and at a Late Stage in the Virus Life Cycle.
J Virol. 89 (24): 12319-29.
Sadewasser, A. et al. (2017) Quantitative proteomic approach identifies Vpr binding protein as novel host factor supporting influenza A virus infections in human cells.
Mol Cell Proteomics. Mar 13. pii: mcp.M116.065904. doi: 10.1074/mcp.M116.065904. [Epub ahead of print]
Liu, Y.V. et al. (2015) Recombinant virus-like particles elicit protective immunity against avian influenza A(H7N9) virus infection in ferrets.
Vaccine. 33 (18): 2152-8.
Herrmann, V.L. et al. (2015) Cytotoxic T cell vaccination with PLGA microspheres interferes with influenza A virus replication in the lung and suppresses the infectious disease.
J Control Release. 216: 121-31.
Huang, M.T. et al. (2015) DcR3 suppresses influenza virus-induced macrophage activation and attenuates pulmonary inflammation and lethality.
J Mol Med (Berl). 93 (10): 1131-43.
Al-Mubarak, F. et al. (2015) Identification of morphological differences between avian influenza A viruses grown in chicken and duck cells.
Virus Res. 199: 9-19.
Yang, C.H. et al. (2017) Influenza A virus upregulates PRPF8 gene expression to increase virus production.
Arch Virol. 162 (5): 1223-35.
Smith, G.E. et al. (2017) Neuraminidase-based recombinant virus-like particles protect against lethal avian influenza A(H5N1) virus infection in ferrets.
Virology. 509: 90-97.
Usui, T. et al. (2020) Outbreaks of highly pathogenic avian influenza in zoo birds caused by HA clade 188.8.131.52 H5N6 subtype viruses in Japan in winter 2016.
Transbound Emerg Dis. 67 (2): 686-697.
Frensing, T. et al. (2016) Influenza virus intracellular replication dynamics, release kinetics, and particle morphology during propagation in MDCK cells.
Appl Microbiol Biotechnol. 100 (16): 7181-92.
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