Epstein-Barr Virus Nuclear Antigen antibody | E1-2.5
Epstein-Barr Virus, also known as HHV-4 or Human herpesvirus 4, is a member of the herpesvirus family and one of the most common infectious viruses known, being responsible for a wide range of illnesses from infectious mononucleosis to nasal-pharyngeal cancer. EBNA-1 is the only viral protein expressed during group 1 latency and mediates the replication and partitioning of the episome during host cell division, binding to a replication origin (oriP) within the viral genome. The Gly-Ala repeat recognized by Mouse anti Epstein-Barr Virus Nuclear Antigen antibody, clone E1-2.5, inhibits the host’s CD8-restricted cytotoxic T-cell response to infected cells, by impairing antigen processing and MHC class I-restricted antigen presentation.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
- This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
- 12 months from date of despatch
- GO Terms
- GO:0005515 protein binding
- GO:0003677 DNA binding
- GO:0006275 regulation of DNA replication
- GO:0006350 transcription
- GO:0030683 evasion by virus of host immune response
- GO:0042025 host cell nucleus
- GO:0045449 regulation of transcription
- For research purposes only
Applications of Epstein-Barr Virus Nuclear Antigen antibody
|Application Name||Verified||Min Dilution||Max Dilution|
Secondary Antibodies Available
Product Specific References
References for Epstein-Barr Virus Nuclear Antigen antibody
Sim, A.C. et al. (2013) Defining the expression hierarchy of latent T-cell epitopes in Epstein-Barr virus infection with TCR-like antibodies.
Sci Rep. 3: 3232.
Münz, C. (2004) Epstein-barr virus nuclear antigen 1: from immunologically invisible to a promising T cell target.
J Exp Med. 199 (10): 1301-4.
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