Renin antibody | 2H2
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WB ResetMouse anti Human Renin:Preservative Free
- Product Type
- Monoclonal Antibody
- Clone
- 2H2
- Isotype
- IgG1
- Specificity
- Renin
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| Mouse anti Human renin antibody, clone 2H2 recognizes human renin also known as Angiotensinogenase. Renin is a 340 amino acid ~37 kDa endopeptidase responsible for the generation angiotensin I from plasma angiotensinogen. Mutations in the REN gene can lead to the development of Renal tubular dysgenesis (RTD), a severe autosomal disorder of renal tubular development leading to perinatal death (Gribouval et al. 2005). Mutation of the REN gene can also lead to Familial juvenile hyperuricemic nephropathy 2 (HNFJ2) characterized by juvenile onset progressive renal failure and anemia (Zivna et al. 2009). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from ascites
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Immunogen
- Recombinant protein corresponding to aa 24-407 of human Renin.
- Approx. Protein Concentrations
- Ig concentration 0.5 mg/ml
- Fusion Partners
- Spleen cells from immunized Balb/c mice were fused with cells from the Sp2/0 myeloma cell line.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
0.1 | 10 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- RRID
- AB_2269568
- UniProt
- P00797
- Entrez Gene
- REN
- GO Terms
- GO:0002003 angiotensin maturation
- GO:0016020 membrane
- GO:0004190 aspartic-type endopeptidase activity
- GO:0005615 extracellular space
- GO:0043408 regulation of MAPKKK cascade
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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