Renin antibody | 2H2

Mouse anti Human Renin:Preservative Free

Product Type
Monoclonal Antibody
Clone
2H2
Isotype
IgG1
Specificity
Renin

Product Code Applications Pack Size List Price Your Price Qty
MCA3411Z
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
WB 0.1 mg loader
List Price Your Price
loader
Search for Batch Specific Datasheets

Mouse anti Human renin antibody, clone 2H2 recognizes human renin also known as Angiotensinogenase. Renin is a 340 amino acid ~37 kDa endopeptidase responsible for the generation angiotensin I from plasma angiotensinogen.

Mutations in the REN gene can lead to the development of Renal tubular dysgenesis (RTD), a severe autosomal disorder of renal tubular development leading to perinatal death (Gribouval et al. 2005). Mutation of the REN gene can also lead to Familial juvenile hyperuricemic nephropathy 2 (HNFJ2) characterized by juvenile onset progressive renal failure and anemia (Zivna et al. 2009).

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from ascites
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
None present
Immunogen
Recombinant protein corresponding to aa 24-407 of human Renin.
Approx. Protein Concentrations
Ig concentration 0.5 mg/ml
Fusion Partners
Spleen cells from immunized Balb/c mice were fused with cells from the Sp2/0 myeloma cell line.
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Western Blotting 0.1 10 ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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Description Goat anti Mouse IgG (H/L):DyLight®650 (Multi Species Adsorbed)
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Description Goat anti Mouse IgG (H/L):DyLight®550 (Multi Species Adsorbed)

RRID
AB_2269568
UniProt
P00797
Entrez Gene
REN
GO Terms
GO:0002003 angiotensin maturation
GO:0016020 membrane
GO:0004190 aspartic-type endopeptidase activity
GO:0005615 extracellular space
GO:0043408 regulation of MAPKKK cascade
Request a different product with this specificity

Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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