Renin antibody | 2H2
Mouse anti Human Renin:Preservative Free
- Product Type
- Monoclonal Antibody
- Clone
- 2H2
- Isotype
- IgG1
- Specificity
- Renin
Mouse anti Human renin antibody, clone 2H2 recognizes human renin also known as Angiotensinogenase. Renin is a 340 amino acid ~37 kDa endopeptidase responsible for the generation angiotensin I from plasma angiotensinogen. Mutations in the REN gene can lead to the development of Renal tubular dysgenesis (RTD), a severe autosomal disorder of renal tubular development leading to perinatal death (Gribouval et al. 2005). Mutation of the REN gene can also lead to Familial juvenile hyperuricemic nephropathy 2 (HNFJ2) characterized by juvenile onset progressive renal failure and anemia (Zivna et al. 2009). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from ascites
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Immunogen
- Recombinant protein corresponding to aa 24-407 of human Renin.
- Approx. Protein Concentrations
- Ig concentration 0.5 mg/ml
- Fusion Partners
- Spleen cells from immunized Balb/c mice were fused with cells from the Sp2/0 myeloma cell line.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Western Blotting | 0.1 | 10 ug/ml |
References for Renin antibody
-
Montes, E. et al. (2012) Renin is an angiotensin-independent profibrotic mediator: role in pulmonary fibrosis.
Eur Respir J. 39 (1): 141-8.
- RRID
- AB_2269568
- UniProt
- P00797
- Entrez Gene
- REN
- GO Terms
- GO:0002003 angiotensin maturation
- GO:0016020 membrane
- GO:0004190 aspartic-type endopeptidase activity
- GO:0005615 extracellular space
- GO:0043408 regulation of MAPKKK cascade
MCA3411Z
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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