Mouse anti Human Myeloperoxidase antibody, clone 4A4 recognizes myeloperoxidase (MPO). MPO is an important component of azurophilic granules in neutrophils, being involved in microbicidal processes. The protein is a multimer of 2 heavy chains (~55 kDa) and two light chains (~15 kDa), the heavy chains being linked by a disulphide bond.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Human myeloperoxidase.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
- 12 months from date of despatch
- Entrez Gene
- GO Terms
stored secretory granule
low-density lipoprotein particle remodeling
hydrogen peroxide catabolic process
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Myeloperoxidase antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
Copyright © 2021 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
Product Specific References
References for Myeloperoxidase antibody
Chatfield, S.M. et al. (2018) Monosodium Urate Crystals Generate Nuclease-Resistant Neutrophil Extracellular Traps via a Distinct Molecular Pathway.
J Immunol. 200 (5): 1802-16.
Demoruelle, M.K. et al. (2017) Anti-Citrullinated Protein Antibodies Are Associated With Neutrophil Extracellular Traps in the Sputum in Relatives of Rheumatoid Arthritis Patients.
Arthritis Rheumatol. 69 (6): 1165-75.
Demoruelle, M.K. et al. (2018) Antibody Responses to Citrullinated and Noncitrullinated Antigens in the Sputum of Subjects With Rheumatoid Arthritis and Subjects at Risk for Development of Rheumatoid Arthritis.
Arthritis Rheumatol. 70 (4): 516-27.
Mikacenic, C. et al. (2018) Neutrophil extracellular traps (NETs) are increased in the alveolar spaces of patients with ventilator-associated pneumonia.
Crit Care. 22 (1): 358.
Guo, L. et al. (2019) A high-risk luminal A dominant breast cancer subtype with increased mobility.
Breast Cancer Res Treat. 175 (2): 459-72.
Helseth, R. et al. (2019) Neutrophil Extracellular Trap Components Associate with Infarct Size, Ventricular Function, and Clinical Outcome in STEMI.
Mediators of Inflammation. 2019: 1-10.
Donkel, S.J. et al. (2021) Circulating Myeloperoxidase (MPO)-DNA complexes as marker for Neutrophil Extracellular Traps (NETs) levels and the association with cardiovascular risk factors in the general population.
PLoS One. 16 (8): e0253698.
Zenlander, R. et al. (2021) Neutrophil extracellular traps in patients with liver cirrhosis and hepatocellular carcinoma.
Sci Rep. 11 (1): 18025.
Zapponi, K.C.S. et al. (2021) Neutrophil activation and circulating neutrophil extracellular traps are increased in venous thromboembolism patients for at least one year after the clinical event.
J Thromb Thrombolysis. Aug 27 [Epub ahead of print].
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