Myeloperoxidase antibody | 4A4
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|Mouse anti Human Myeloperoxidase antibody, clone 4A4 recognizes myeloperoxidase (MPO). MPO is an important component of azurophilic granules in neutrophils, being involved in microbicidal processes. The protein is a multimer of 2 heavy chains (~55 kDa) and two light chains (~15 kDa), the heavy chains being linked by a disulphide bond.|
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Human myeloperoxidase.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
References for Myeloperoxidase antibody
Chatfield, S.M. et al. (2018) Monosodium Urate Crystals Generate Nuclease-Resistant Neutrophil Extracellular Traps via a Distinct Molecular Pathway.
J Immunol. 200 (5): 1802-16.
Demoruelle, M.K. et al. (2017) Anti-Citrullinated Protein Antibodies Are Associated With Neutrophil Extracellular Traps in the Sputum in Relatives of Rheumatoid Arthritis Patients.
Arthritis Rheumatol. 69 (6): 1165-75.
Demoruelle, M.K. et al. (2018) Antibody Responses to Citrullinated and Noncitrullinated Antigens in the Sputum of Subjects With Rheumatoid Arthritis and Subjects at Risk for Development of Rheumatoid Arthritis.
Arthritis Rheumatol. 70 (4): 516-27.
Mikacenic, C. et al. (2018) Neutrophil extracellular traps (NETs) are increased in the alveolar spaces of patients with ventilator-associated pneumonia.
Crit Care. 22 (1): 358.
Guo, L. et al. (2019) A high-risk luminal A dominant breast cancer subtype with increased mobility.
Breast Cancer Res Treat. 175 (2): 459-72.
Helseth, R. et al. (2019) Neutrophil Extracellular Trap Components Associate with Infarct Size, Ventricular Function, and Clinical Outcome in STEMI.
Mediators of Inflammation. 2019: 1-10.
Donkel, S.J. et al. (2021) Circulating Myeloperoxidase (MPO)-DNA complexes as marker for Neutrophil Extracellular Traps (NETs) levels and the association with cardiovascular risk factors in the general population.
PLoS One. 16 (8): e0253698.
Zenlander, R. et al. (2021) Neutrophil extracellular traps in patients with liver cirrhosis and hepatocellular carcinoma.
Sci Rep. 11 (1): 18025.
View The Latest Product References
Zapponi, K.C.S. et al. (2021) Neutrophil activation and circulating neutrophil extracellular traps are increased in venous thromboembolism patients for at least one year after the clinical event.
J Thromb Thrombolysis. Aug 27 [Epub ahead of print].
Kluge, K.E. et al. (2020) Complement Activation in Association with Markers of Neutrophil Extracellular Traps and Acute Myocardial Infarction in Stable Coronary Artery Disease.
Mediators Inflamm. 2020: 5080743.
Langseth, M.S. et al. (2020) Double-Stranded DNA and NETs Components in Relation to Clinical Outcome After ST-Elevation Myocardial Infarction.
Sci Rep. 10 (1): 5007.
Tilly, M.J. et al. (2022) Immunothrombosis and new-onset atrial fibrillation in the general population: the Rotterdam Study.
Clin Res Cardiol. 111 (1): 96-104.
Takeuchi, S. et al. (2022) Elevated Myeloperoxidase-DNA Complex Levels in Sera of Patients with IgA Vasculitis.
Pathobiology. 89 (1): 23-8.
- Entrez Gene
- GO Terms
- GO:0003682 chromatin binding
- GO:0006952 defense response
- GO:0005764 lysosome
- GO:0004601 peroxidase activity
- GO:0005615 extracellular space
- GO:0005634 nucleus
- GO:0030141 stored secretory granule
- GO:0055114 oxidation-reduction process
- GO:0006916 anti-apoptosis
- View More GO Terms
- GO:0008201 heparin binding
- GO:0020037 heme binding
- GO:0034374 low-density lipoprotein particle remodeling
- GO:0042744 hydrogen peroxide catabolic process
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"View all Anti-Human Products
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