Mouse anti Human Myeloperoxidase antibody, clone 4A4 recognizes myeloperoxidase (MPO). MPO is an important component of azurophilic granules in neutrophils, being involved in microbicidal processes. The protein is a multimer of 2 heavy chains (~55 kDa) and two light chains (~15 kDa), the heavy chains being linked by a disulphide bond.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- Human myeloperoxidase.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 18 months from date of despatch.
- Entrez Gene
- GO Terms
stored secretory granule
low-density lipoprotein particle remodeling
hydrogen peroxide catabolic process
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of Myeloperoxidase antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
Copyright © 2019 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
Product Specific References
References for Myeloperoxidase antibody
Chatfield, S.M. et al. (2018) Monosodium Urate Crystals Generate Nuclease-Resistant Neutrophil Extracellular Traps via a Distinct Molecular Pathway.
J Immunol. Jan 24 [Epub ahead of print].
Demoruelle, M.K. et al. (2017) Anti-Citrullinated Protein Antibodies Are Associated With Neutrophil Extracellular Traps in the Sputum in Relatives of Rheumatoid Arthritis Patients.
Arthritis Rheumatol. 69 (6): 1165-75.
Demoruelle, M.K. et al. (2017) Antibody Responses to Citrullinated and Non-Citrullinated Antigens in the Sputum of Subjects with and At-Risk for Rheumatoid Arthritis.
Arthritis Rheumatol. Dec 20 [Epub ahead of print].
Mikacenic, C. et al. (2018) Neutrophil extracellular traps (NETs) are increased in the alveolar spaces of patients with ventilator-associated pneumonia.
Crit Care. 22 (1): 358.
Guo, L. et al. (2019) A high-risk luminal A dominant breast cancer subtype with increased mobility.
Breast Cancer Res Treat. Feb 19 [Epub ahead of print].