MTMR2 antibody | 4G6
Mouse anti Human MTMR2 antibody, clone 4G6 recognizes human Myotubularin-related protein 2, also known as MTMR2, Phosphatidylinositol-3,5-bisphosphate 3-phosphatase or Phosphatidylinositol-3-phosphate phosphatase. MTMR2 is a 643 amino acid ~75 kDa phosphatase.
Mutations in the MTMR2 gene can lead to development of Charcot-Marie-Tooth disease 4B1 (CMT4B1), an autosomal recessive demyelinating disease marked by progressive atrophy and weakness of peroneal and arm muscles (Bolino et al. 2000).
Mutations in the MTMR2 gene can lead to development of Charcot-Marie-Tooth disease 4B1 (CMT4B1), an autosomal recessive demyelinating disease marked by progressive atrophy and weakness of peroneal and arm muscles (Bolino et al. 2000).
Product Details
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Immunogen
- Recombinant protein corresponding to aa 5-101 of human MTMR2
- Approx. Protein Concentrations
- Ig concentration 0.5 mg/ml
- Fusion Partners
- Spleen cells from immunized Balb/c mice were fused with cells from the Sp2/0 myeloma cell line.
Storage Information
- Storage
- Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 18 months from date of despatch.
More Information
- UniProt
- Q13614 Related reagents
- Entrez Gene
- MTMR2 Related reagents
- GO Terms
- GO:0004437 inositol or phosphatidylinositol phosphatase activity
- GO:0004725 protein tyrosine phosphatase activity
- GO:0005634 nucleus
- GO:0006470 protein dephosphorylation
- GO:0008138 protein tyrosine/serine/threonine phosphatase activity
- Regulatory
- For research purposes only
Applications of MTMR2 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting | 0.1 | 10 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
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