MDM4 antibody | AB01/4H9
Mouse anti Human MDM4
- Product Type
- Monoclonal Antibody
- Clone
- AB01/4H9
- Isotype
- IgG1
- Specificity
- MDM4
Antibody Quality and Performance Guarantee
| Mouse anti human MDM4 antibody, clone AB01/4H9 recognizes protein MDM4 also known as p53-binding protein MDM4. MDM4 is comprised of four key domains, which include an N-terminus, an acidic region, a zinc region and a C-terminal RING. It is on this N-terminus whereby MDM4 binds to the major tumor suppressor p53 (Haupt et al. 2019). MDM4 is structurally similar to MDM2. Both proteins are involved in suppression of p53 activity and have been seen to increase in a number of cancers (Yu et al. 2020). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Carrier Free
- Yes
- Immunogen
- E. coli-derived recombinant protein, aa 1-490 of human MDM4.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1,000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Mouse anti Human MDM4 detects a band of approximately 70 kDa in HEK293 cell lysates.
- UniProt
- O15151
- Entrez Gene
- MDM4
- GO Terms
- GO:0000122 negative regulation of transcription from RNA polymerase II promoter
- GO:0006915 apoptosis
- GO:0005634 nucleus
- GO:0006461 protein complex assembly
- GO:0008270 zinc ion binding
- GO:0008283 cell proliferation
- GO:0008285 negative regulation of cell proliferation
- GO:0050821 protein stabilization
- GO:0019899 enzyme binding
- View More GO Terms
- GO:0042177 negative regulation of protein catabolic process
- GO:0045023 G0 to G1 transition
MCA6426GA
100007866
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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