MAdCAM-1 antibody | CA 102.2C1

Mouse anti Human MAdCAM-1:Preservative Free

Product Type
Monoclonal Antibody
Clone
CA 102.2C1
Isotype
IgG1
Specificity
MAdCAM-1

Product Code Applications Pack Size List Price Your Price Qty
MCA2096Z
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
E FN WB 0.1 mg loader
List Price Your Price
loader
Search for Batch Specific Datasheets

Mouse anti Human MAdCAM-1 antibody, clone CA102.2C1 recognizes human mucosal addressin cell adhesion molecule -1, also known as MAdCAM-1. Human MAdCAM-1 is a 382 amino acid ~40-60 kDa single pass type 1 transmembrane glycoprotein expressed by vascular endothelium (UniProt :Q13477).

Mouse anti Human MAdCAM-1 antibody, clone CA102.2C1 has been reported to block the binding of human cells expressing alpha4 Beta7 to immobilized MAdCAM-1 in vitro (Grant et al. 2001).

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
None present
Immunogen
Bacterially expressed human MAdCAM-1.
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Regulatory
For research purposes only
Guarantee
Guaranteed for 12 months from the date of despatch or until the date of expiry, whichever comes first. Please see label for expiry date.

Store at -20o only.

This product should be stored undiluted.

Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the product. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Functional Assays
Western Blotting
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.

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References for MAdCAM-1 antibody

  1. Eksteen, B. et al. (2006) Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10.
    J Immunol. 177: 593-603.
  2. Liaskou, E. et al. (2011) Regulation of mucosal addressin cell adhesion molecule 1 expression in human and mice by vascular adhesion protein 1 amine oxidase activity.
    Hepatology. 53: 661-72.
  3. Krissansen, G. et al. (2007) Monoclonal Antibodies That Recognise Mucosal Addressin Cell Adhesion Molecule-1 (Madcam-1), Soluble Madcam-1 And Uses Thereof
    US Patent Application: US20070202097A1.
  4. Liaskou, E. (2010) MAdCAM-1 Expression and Function in Human Liver.
    PhD Thesis, University of Birmingham, UK.

Synonyms
Mucosal Addressin Cell Adhesion MOLECULE-1
RRID
AB_324565
UniProt
Q13477
Entrez Gene
MADCAM1
GO Terms
GO:0005886 plasma membrane
GO:0007155 cell adhesion
GO:0016021 integral to membrane
GO:0007165 signal transduction
GO:0005624 membrane fraction
GO:0006955 immune response
GO:0050776 regulation of immune response
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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