MAdCAM-1 antibody | CA 102.2C1

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Mouse anti Human MAdCAM-1:Preservative Free

Product Type: Monoclonal Antibody
Clone: CA 102.2C1
Isotype: IgG1

Product Code	Applications	Datasheet	MSDS	Pack Size	List Price	Quantity
MCA2096Z	E FN WB			0.1 mg

Mouse anti Human MAdCAM-1 antibody, clone CA102.2C1 recognizes human mucosal addressin cell adhesion molecule -1, also known as MAdCAM-1. Human MAdCAM-1 is a 382 amino acid ~40-60 kDa single pass type 1 transmembrane glycoprotein expressed by vascular endothelium (http://www.uniprot.org/uniprot/Q13477).

Mouse anti Human MAdCAM-1 antibody, clone CA102.2C1 has been reported to block the binding of human cells expressing alpha4 Beta7 to immobilized MAdCAM-1 in vitro (Grant et al. 2001).

Product Details

Target Species: Human
Product Form: Purified IgG - liquid
Preparation: Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution: Phosphate buffered saline
Preservative Stabilisers: None present
Immunogen: Bacterially expressed human MAdCAM-1.
Approx. Protein Concentrations: IgG concentration 1.0 mg/ml

Storage Information

Storage: Store at -20^o only.

This product should be stored undiluted.

Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the product. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

More Information

UniProt: Q13477 Related reagents
Entrez Gene: MADCAM1 Related reagents
GO Terms: GO:0005886 plasma membrane; GO:0007155 cell adhesion; GO:0016021 integral to membrane; GO:0007165 signal transduction; GO:0005624 membrane fraction; GO:0006955 immune response; GO:0050776 regulation of immune response
Regulatory: For research purposes only

Applications of MAdCAM-1 antibody

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.

Application Name	Verified	Min Dilution	Max Dilution
ELISA
Functional Assays
Western Blotting

Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.

Secondary Antibodies Available

Description	Product Code	Pack Size	Applications
Goat anti Mouse IgG (H/L):Alk. Phos. (Multi Species Adsorbed)	STAR117A	0.5 mg	E WB
Goat anti Mouse IgG (H/L):DyLight®488 (Multi Species Adsorbed)	STAR117D488GA	0.1 mg	F IF
Goat anti Mouse IgG (H/L):DyLight®549 (Multi Species Adsorbed)	STAR117D549GA	0.1 mg	F IF WB
Goat anti Mouse IgG (H/L):DyLight®649 (Multi Species Adsorbed)	STAR117D649GA	0.1 mg	F IF
Goat anti Mouse IgG (H/L):DyLight®680 (Multi Species Adsorbed)	STAR117D680GA	0.1 mg	F WB
Goat anti Mouse IgG (H/L):DyLight®800 (Multi Species Adsorbed)	STAR117D800GA	0.1 mg	F IF WB
Goat anti Mouse IgG (H/L):FITC (Multi Species Adsorbed)	STAR117F	0.5 mg	F
Goat anti Mouse IgG (H/L):HRP (Multi Species Adsorbed)	STAR117P	0.5 mg	E WB
Goat anti Mouse IgG (Fc):FITC	STAR120F	1 mg	C F
Goat anti Mouse IgG (Fc):HRP	STAR120P	1 mg	E WB
Rabbit F(ab')2 anti Mouse IgG:RPE	STAR12A	1 ml	F
Rabbit F(ab')2 anti Mouse IgG:HRP (Human Adsorbed)	STAR13B	1 mg	C E P RE WB
Goat anti Mouse IgG:FITC (Rat Adsorbed)	STAR70	0.5 mg	F
Goat anti Mouse IgG:RPE (Rat Adsorbed)	STAR76	1 ml	F
Goat anti Mouse IgG:HRP (Rat Adsorbed)	STAR77	0.5 mg	C E P
Goat anti Mouse IgG/A/M:Alk. Phos.	STAR87A	1 mg	C E WB
Goat anti Mouse IgG/A/M:HRP (Human Adsorbed)	STAR87P	1 mg	E
Rabbit F(ab')2 anti Mouse IgG:Dylight®800	STAR8D800GA	0.1 mg	F IF WB
Rabbit F(ab')2 anti Mouse IgG:FITC	STAR9B	1 mg	F

Product Specific References

References for MAdCAM-1 antibody

Eksteen, B. et al. (2006) Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10.
J Immunol. 177: 593-603.
Liaskou, E. et al. (2011) Regulation of mucosal addressin cell adhesion molecule 1 expression in human and mice by vascular adhesion protein 1 amine oxidase activity.
Hepatology. 53: 661-72.
Krissansen, G. et al. (2007) Monoclonal Antibodies That Recognise Mucosal Addressin Cell Adhesion Molecule-1 (Madcam-1), Soluble Madcam-1 And Uses Thereof
US Patent Application: US20070202097A1.

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