Lactoferrin antibody | 2B8
Mouse anti Human Lactoferrin
- Product Type
- Monoclonal Antibody
|Mouse anti Human Lactoferrin antibody, clone 2B8 recognizes human lactoferrin, a ~80 kDa globular iron binding glycoprotein found in body secretions such as milk and saliva and is a member of the transferrin family proteins. Transferrins control the level of free iron in the body, by binding and transporting iron. Lactoferrin does not appear to have a transporting function, instead it has antimicrobial activity, by keeping the levels of iron in body fluids low and thus preventing microbes from acquiring iron. Removing free iron from body fluids and inflamed areas also serve to protect against the damaging effects of free radicals.Lactoferrin is used as a therapeutic and prophylactic treatment of various illnesses, such as cancers and intestinal illnesses.
Mouse anti Human Lactoferrin antibody, clone 2B8 does not cross-react with human transferrins or other serum proteins.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from ascites
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Purified Lactoferrin from human milk.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised Balb/c mice were fused with cells of the Sp2/0 myeloma cell line.
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
- Western Blotting
- MCA2763 detects a band of approximately 77kDa in immunoblots of whole serum proteins.
References for Lactoferrin antibody
Naegelen I et al. (2014) An essential role of syntaxin 3 protein for granule exocytosis and secretion of IL-1α, IL-1β, IL-12b, and CCL4 from differentiated HL-60 cells.
J Leukoc Biol. pii: jlb.3A0514-254RR.
Shiga Y et al. (2015) Recombinant human lactoferrin-Fc fusion with an improved plasma half-life.
Eur J Pharm Sci. 67: 136-43.
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