KIR antibody | NKVFS1
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F ResetMouse anti Human KIR
- Product Type
- Monoclonal Antibody
- Clone
- NKVFS1
- Isotype
- IgG1
- Specificity
- KIR
Antibody Quality and 
Unrivaled 
| Mouse anti Human KIR antibody, clone NKVFS1 recognizes KIR2D members of the killer cell immunoglobulin (Ig)-like receptor (KIR) family, CD158a, CD158b and P50.3. KIR2D family members are cell surface glycoproteins with two Ig domains, which are expressed on natural killer cells and some T cells. Mouse anti Human KIR antibody, clone NKVFS1 recognizes the long and short forms CD158a and CD158b (KIR2DL, KIR2DS1 and KIR2DS2 respectively) and also p50.3 (KIR2DS4). Mouse anti Human KIR antibody, clone NKVFS1 is reported to have functional activity, activating NK cell cytotoxicity via KIR2DS and inhibiting via KIR2DL forms.. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- MCA2243: Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- MCA2243GA: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide - Carrier Free
- Yes
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
||
| Flow Cytometry | |
1/50 | 1/100 |
| Immunoprecipitation | |
||
| Western Blotting | |
Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 106 cells in 100ul.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse IgG1 Negative Control | MCA928 | F | 100 Tests |
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| List Price | Your Price | ||||||
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| Description | Mouse IgG1 Negative Control | ||||||
References for KIR antibody
-
Spaggiari, G.M. et al. (2002) Soluble HLA class I molecules induce natural killer cell apoptosis through the engagement of CD8: evidence for a negative regulation exerted by members of the inhibitory receptor superfamily.
Blood. 99 (5): 1706-14. -
Spaggiari, G.M. et al. (2002) Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-activating HLA class I receptors through FasL-Fas interaction.
Blood. 100 (12): 4098-107. -
Older Aguilar, A.M. et al. (2010) Coevolution of killer cell Ig-like receptors with HLA-C to become the major variable regulators of human NK cells.
J Immunol. 185 (7): 4238-51. -
Patterson, S. et al. (2008) Human invariant NKT cells display alloreactivity instructed by invariant TCR-CD1d interaction and killer Ig receptors.
J Immunol. 181 (5): 3268-76. -
Hilton, H.G. et al. (2015) The production of KIR-Fc fusion proteins and their use in a multiplex HLA class I binding assay.
J Immunol Methods. 425: 79-87. -
Moesta, A.K. et al. (2009) Chimpanzees use more varied receptors and ligands than humans for inhibitory killer cell Ig-like receptor recognition of the MHC-C1 and MHC-C2 epitopes.
J Immunol. 182 (6): 3628-37. -
Van Der Ploeg, K. et al. (2017) Modulation of Human Leukocyte Antigen-C by Human Cytomegalovirus Stimulates KIR2DS1 Recognition by Natural Killer Cells.
Front Immunol. 8: 298. -
Wang, Y. et al. (2009) Characteristics of expanded CD4+CD28null T cells in patients with chronic hepatitis B.
Immunol Invest. 38 (5): 434-46.
View The Latest Product References
-
Wijaya, R.S. et al. (2020) Expansion of dysfunctional CD56-CD16+ NK cells in chronic hepatitis B patients.
Liver Int. Dec 23 [Epub ahead of print].
- Synonyms
- Killer Cell IMMUNOGLOBIN-LIKE Receptors
- RRID
- AB_2130355
- UniProt
- P43626
- P43627
- P43628
- Q14954
- P43631
- P43632
- Entrez Gene
- KIR2DL1
- KIR2DL2
- KIR2DL3
- KIR2DS2
- KIR2DS4
- KIR2DS1
- GO Terms
- GO:0005515 protein binding
- GO:0002769 natural killer cell inhibitory signaling pathway
- GO:0004872 receptor activity
- GO:0005887 integral to plasma membrane
- GO:0006955 immune response
- GO:0005886 plasma membrane
- GO:0016021 integral to membrane
- GO:0050776 regulation of immune response
- GO:0003823 antigen binding
- View More GO Terms
- GO:0004888 transmembrane receptor activity
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