Integrin Alpha 9 Beta 1 antibody | Y9A2
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Mouse anti Human Integrin Alpha 9 Beta 1
- Product Type
- Monoclonal Antibody
- Clone
- Y9A2
- Isotype
- IgG1
- Specificity
- Integrin Alpha 9 Beta 1
Antibody Quality and Performance Guarantee
| Mouse anti Human Integrin alpha 9 beta 1 antibody, clone Y9A2 recognizes human Integrin alpha 9/ beta 1, a receptor for VCAM1, cytotactin and osteopontin. In functional applications Mouse anti Human Integrin alpha 9 beta 1 antibody, clone Y9A2 has been shown to cause 100% inhibition of α9β1-mediated adhesion to the third fibronectin type III repeat in tenascin at <10ug/ml. Mouse anti Human Integrin alpha 9 beta 1 antibody, clone Y9A2 has been used to demonstrate Itgα9 blocking of progenitor cell proliferation (Schreiber et al. 2009). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Guinea Pig - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Antibody purified from ascites
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Immunogen
- Murine L cells transfected with human alpha-9 integrin.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry |  |
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| Functional Assays | |
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| Immunohistology - Frozen | |||
| Immunohistology - Paraffin | |||
| Immunohistology - Resin | |||
| Immunoprecipitation | |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse IgG1 Negative Control | MCA928 | F | 100 Tests |
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| List Price | Your Price | ||||||
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| Description | Mouse IgG1 Negative Control | ||||||
References for Integrin Alpha 9 Beta 1 antibody
-
Wang, A. et al. (1996) Differential regulation of airway epithelial integrins by growth factors.
Am J Respir Cell Mol Biol. 15: 664-72. -
Bazan-Socha, S. et al. (2004) Structural requirements of MLD-containing disintegrins for functional interaction with alpha 4 beta 1 and alpha 9 beta1 integrins.
Biochemistry. 43:1639-47. -
Graham KL et al. (2005) Rotaviruses interact with alpha4beta7 and alpha4beta1 integrins by binding the same integrin domains as natural ligands.
J Gen Virol. 86 (Pt 12): 3397-408. -
Kawataki, T. et al. (2007) Laminin isoforms and their integrin receptors in glioma cell migration and invasiveness: Evidence for a role of alpha5-laminin(s) and alpha3beta1 integrin.
Exp Cell Res. 313 (18): 3819-31. -
Staniszewska, I. et al. (2008) Integrin alpha9 beta1 is a receptor for nerve growth factor and other neurotrophins.
J Cell Sci. 121: 504-13. -
Schreiber, T.D. et al. (2009) The integrin alpha9beta1 on hematopoietic stem and progenitor cells: involvement in cell adhesion, proliferation and differentiation.
Haematologica. 94 (11): 1493-501. -
Sime W et al. (2009) Human mast cells adhere to and migrate on epithelial and vascular basement membrane laminins LM-332 and LM-511 via alpha3beta1 integrin.
J Immunol. 183 (7): 4657-65. -
Wagner, B.J. et al. (2011) Simvastatin reduces tumor cell adhesion to human peritoneal mesothelial cells by decreased expression of VCAM-1 and β1 integrin.
Int J Oncol. 39 (6): 1593-600.
View The Latest Product References
- RRID
- AB_617319
- UniProt
- Q13797
- Entrez Gene
- ITGA9
- GO Terms
- GO:0007155 cell adhesion
- GO:0004872 receptor activity
- GO:0008305 integrin complex
- GO:0007229 integrin-mediated signaling pathway
- GO:0007411 axon guidance
OBT1715Z
148065
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