Integrin Alpha 9 Beta 1 antibody | Y9A2

Mouse anti Human Integrin Alpha 9 Beta 1

Product Type
Monoclonal Antibody
Clone
Y9A2
Isotype
IgG1
Specificity
Integrin Alpha 9 Beta 1

Product Code Applications Pack Size List Price Your Price Qty
OBT1715Z
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
F FN IP 0.1 mg loader
List Price Your Price
loader
Search for Batch Specific Datasheets

Mouse anti Human Integrin alpha 9 beta 1 antibody, clone Y9A2 recognizes human Integrin alpha 9/ beta 1, a receptor for VCAM1, cytotactin and osteopontin.

In functional applications Mouse anti Human Integrin alpha 9 beta 1 antibody, clone Y9A2 has been shown to cause 100% inhibition of α9β1-mediated adhesion to the third fibronectin type III repeat in tenascin at <10ug/ml. Mouse anti Human Integrin alpha 9 beta 1 antibody, clone Y9A2 has been used to demonstrate Itgα9 blocking of progenitor cell proliferation (Schreiber et al. 2009).

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Guinea Pig
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Antibody purified from ascites
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
None present
Immunogen
Murine L cells transfected with human alpha-9 integrin.
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry
Functional Assays
Immunohistology - Frozen
Immunohistology - Paraffin
Immunohistology - Resin
Immunoprecipitation
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.

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References for Integrin Alpha 9 Beta 1 antibody

  1. Wang, A. et al. (1996) Differential regulation of airway epithelial integrins by growth factors.
    Am J Respir Cell Mol Biol. 15: 664-72.
  2. Staniszewska, I. et al. (2008) Integrin alpha9 beta1 is a receptor for nerve growth factor and other neurotrophins.
    J Cell Sci. 121: 504-13.
  3. Bazan-Socha, S. et al. (2004) Structural requirements of MLD-containing disintegrins for functional interaction with alpha 4 beta 1 and alpha 9 beta1 integrins.
    Biochemistry. 43:1639-47.
  4. Kawataki, T. et al. (2007) Laminin isoforms and their integrin receptors in glioma cell migration and invasiveness: Evidence for a role of alpha5-laminin(s) and alpha3beta1 integrin.
    Exp Cell Res. 313 (18): 3819-31.
  5. Graham KL et al. (2005) Rotaviruses interact with alpha4beta7 and alpha4beta1 integrins by binding the same integrin domains as natural ligands.
    J Gen Virol. 86 (Pt 12): 3397-408.
  6. Sime W et al. (2009) Human mast cells adhere to and migrate on epithelial and vascular basement membrane laminins LM-332 and LM-511 via alpha3beta1 integrin.
    J Immunol. 183 (7): 4657-65.
  7. Schreiber, T.D. et al. (2009) The integrin alpha9beta1 on hematopoietic stem and progenitor cells: involvement in cell adhesion, proliferation and differentiation.
    Haematologica. 94 (11): 1493-501.
  8. Wagner, B.J. et al. (2011) Simvastatin reduces tumor cell adhesion to human peritoneal mesothelial cells by decreased expression of VCAM-1 and β1 integrin.
    Int J Oncol. 39 (6): 1593-600.
  9. View The Latest Product References

Flow Cytometry

Functional Assays

RRID
AB_617319
UniProt
Q13797
Entrez Gene
ITGA9
GO Terms
GO:0007155 cell adhesion
GO:0004872 receptor activity
GO:0008305 integrin complex
GO:0007229 integrin-mediated signaling pathway
GO:0007411 axon guidance