Integrin Alpha 9 Beta 1 antibody | Y9A2
Mouse anti Human Integrin Alpha 9 Beta 1
- Product Type
- Monoclonal Antibody
- Integrin Alpha 9 Beta 1
|Mouse anti Human Integrin alpha 9 beta 1 antibody, clone Y9A2 recognizes human Integrin alpha 9/ beta 1, a receptor for VCAM1, cytotactin and osteopontin.
In functional applications Mouse anti Human Integrin alpha 9 beta 1 antibody, clone Y9A2 has been shown to cause 100% inhibition of α9β1-mediated adhesion to the third fibronectin type III repeat in tenascin at <10ug/ml. Mouse anti Human Integrin alpha 9 beta 1 antibody, clone Y9A2 has been used to demonstrate Itgα9 blocking of progenitor cell proliferation (Schreiber et al. 2009).
- Target Species
- Species Cross-Reactivity
Target Species Cross Reactivity Guinea Pig
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Antibody purified from ascites
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Murine L cells transfected with human alpha-9 integrin.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- For research purposes only
- 12 months from date of despatch
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen|
|Immunohistology - Paraffin|
|Immunohistology - Resin|
References for Integrin Alpha 9 Beta 1 antibody
Wang, A. et al. (1996) Differential regulation of airway epithelial integrins by growth factors.
Am J Respir Cell Mol Biol. 15: 664-72.
Staniszewska, I. et al. (2008) Integrin alpha9 beta1 is a receptor for nerve growth factor and other neurotrophins.
J Cell Sci. 121: 504-13.
Bazan-Socha, S. et al. (2004) Structural requirements of MLD-containing disintegrins for functional interaction with alpha 4 beta 1 and alpha 9 beta1 integrins.
Kawataki, T. et al. (2007) Laminin isoforms and their integrin receptors in glioma cell migration and invasiveness: Evidence for a role of alpha5-laminin(s) and alpha3beta1 integrin.
Exp Cell Res. 313 (18): 3819-31.
Graham KL et al. (2005) Rotaviruses interact with alpha4beta7 and alpha4beta1 integrins by binding the same integrin domains as natural ligands.
J Gen Virol. 86 (Pt 12): 3397-408.
Sime W et al. (2009) Human mast cells adhere to and migrate on epithelial and vascular basement membrane laminins LM-332 and LM-511 via alpha3beta1 integrin.
J Immunol. 183 (7): 4657-65.
Schreiber, T.D. et al. (2009) The integrin alpha9beta1 on hematopoietic stem and progenitor cells: involvement in cell adhesion, proliferation and differentiation.
Haematologica. 94 (11): 1493-501.
Wagner, B.J. et al. (2011) Simvastatin reduces tumor cell adhesion to human peritoneal mesothelial cells by decreased expression of VCAM-1 and β1 integrin.
Int J Oncol. 39 (6): 1593-600.
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"View all Anti-Human Products
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