IL-34 antibody | D02-3A7
Mouse anti Human INTERLEUKIN-34
- Product Type
- Monoclonal Antibody
- Clone
- D02-3A7
- Isotype
- IgG2b
- Specificity
- IL-34
Antibody Quality and Performance Guarantee
| Mouse anti Human interleukin-34 antibody, clone D02-3A7, recognizes interleukin-34 (IL-34), also known as C16orf77. IL-34 is an inflammatory cytokine with the ability to induce macrophage activation and migration (Zhou et al. 2016). This protein is produced by multiple cell types including endothelial cells, adipocytes, neurons, macrophages, fibroblasts, and epithelial cells (Franzè et al. 2020). IL-34 is involved with development and maintenance of multiple macrophage subsets, including osteoclasts, Langerhans cells, and microglia. If macrophages are cultured in the presence of IL-34, these cells show immunosuppressive properties (Lindau et al. 2018). Due to its inflammatory role, IL-34 dysregulation can be involved with inflammatory bowel disease, rheumatoid arthritis, heart failure, and kidney diseases (Cheng et al. 2017). IL-34 is overexpressed in several cancer types, and tumor cells can produce and respond to this cytokine (Franzè et al. 2020) The purified Mouse anti Human interleukin-34 antibody, clone D02-3A7 (MCA6214GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human interleukin-34 antibody, clone C03-5C3 (MCA6215B) as the detection antibody. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Carrier Free
- Yes
- Immunogen
- E. coli derived recombinant human full length interleukin-34 (Asn21-Pro242)
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Cell fusion between immunized BALB/c mouse spleen cells and mouse myeloma SP2/0
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
1.0 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse anti Human INTERLEUKIN-34:Biotin | MCA6215B | E | 0.1 mg |
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| Description | Mouse anti Human INTERLEUKIN-34:Biotin | ||||||
- UniProt
- Q6ZMJ4
- Entrez Gene
- IL34
- GO Terms
- GO:0001934 positive regulation of protein phosphorylation
- GO:0005125 cytokine activity
- GO:0005157 macrophage colony-stimulating factor receptor binding
- GO:0005615 extracellular space
- GO:0008083 growth factor activity
- GO:0008284 positive regulation of cell proliferation
MCA6214GA
100005154
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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