Mouse anti Human interleukin-32 antibody, clone E03-4C9,
recognizes interleukin-32 (IL-32), also known as NK4 and TAIF. IL-32 is a pro-inflammatory cytokine with roles in inflammation and immune regulation, and its expression is strongly regulated by pathogens and pro-inflammatory cytokines (Hong et al. 2017
). IL-32 promotes inflammation by upregulating other inflammatory cytokines including TNF-α, IL-1β, IL-6, INF-γ, and IL-8 (Al-Shobaili et al. 2018
). Accordingly, a role for IL-32 has been reported in the pathogenesis of chronic inflammatory diseases including IBD, COPD and RA (Damen et al. 2017
). IL-32 is highly expressed in several cancer tissues, and plays a crucial role in cancer development through tumor initiation, cell proliferation, and tumor maintenance (Yan et al. 2018
The purified Mouse anti Human interleukin-32 antibody, clone E03-4C9 (MCA6212GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human interleukin-32 antibody, clone B01-2A7 (MCA6213B
) as the detection antibody.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of IL-32 antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.