GRB14 antibody | I01-10B4
Mouse anti Human GRB14
- Product Type
- Monoclonal Antibody
- Clone
- I01-10B4
- Isotype
- IgG2b
- Specificity
- GRB14
Antibody Quality and Performance Guarantee
| Mouse anti human GRB14 antibody, clone I01-10B4 recognizes growth factor receptor-bound protein (GRB) 14, also known as GRB14 adapter protein. GRB14 is an adapter molecule of the GRB7/10/14 family. GRB14 has been shown to inhibit insulin receptor (IR) catalytic activity and mediate peptide substrate binding. Members of this GRB family have also been shown to interact with other kinases through their SH2 domain. GRB14 is thought to play a role in the regulation of receptor signaling and modulation of thyroid cancer progression (Balogh et al. 2012). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- E. coli-derived recombinant protein, aa 75-249 of human GRB14
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/1,000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Mouse anti Human GRB14 antibody detects a band of 60 kDa in K562 cell lysates
- UniProt
- Q14449
- Entrez Gene
- GRB14
- GO Terms
- GO:0005886 plasma membrane
- GO:0000139 Golgi membrane
- GO:0007596 blood coagulation
- GO:0005829 cytosol
- GO:0007165 signal transduction
- GO:0005070 SH3/SH2 adaptor activity
- GO:0005792 microsome
- GO:0010008 endosome membrane
- GO:0050900 leukocyte migration
- View More GO Terms
MCA6417GA
100007682
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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