Granzyme A antibody | GA6

Product Details
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline.
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
Storage Information
- Storage
- Store at +4oC or at -20oC if preferred.
This product should be stored undiluted.
Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P12544
- Entrez Gene
- GZMA
- GO Terms
- GO:0001772 immunological synapse
- GO:0004252 serine-type endopeptidase activity
- GO:0005576 extracellular region
- GO:0005634 nucleus
- GO:0006922 cleavage of lamin
- GO:0006955 immune response
- GO:0019835 cytolysis
- GO:0032078 negative regulation of endodeoxyribonuclease activity
- GO:0042803 protein homodimerization activity
- GO:0043065 positive regulation of apoptosis
- GO:0043392 negative regulation of DNA binding
- GO:0051354 negative regulation of oxidoreductase activity
- Regulatory
- For research purposes only
Applications of Granzyme A antibody
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Immunohistology - Paraffin 1 | 1/50 | 1/200 | |
Western Blotting |
- 1This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.Sodium citrate buffer pH 6.0 is recommended for this purpose.
Secondary Antibodies Available
Product Specific References
References for Granzyme A antibody
-
Kummer, J.A. et al. (1993) Production and characterization of monoclonal antibodies raised against recombinant human granzymes A and B and showing cross reactions with the natural proteins.
J Immunol Methods. 163 (1): 77-83. -
Mahrus, S. & Craik, C.S. (2005) Selective chemical functional probes of granzymes A and B reveal granzyme B is a major effector of natural killer cell-mediated lysis of target cells.
Chem Biol. 12: 567-77. -
Meade, J.L. et al. (2009) Proteolytic activation of the cytotoxic phenotype during human NK cell development.
J Immunol. 183: 803-13. -
Hochegger, K. et al. (2007) Expression of granzyme A in human polymorphonuclear neutrophils.
Immunology. 121: 166-73. -
Grodzovski, I. et al. (2011) IL-2-granzyme A chimeric protein overcomes multidrug resistance (MDR) through a caspase 3-independent apoptotic pathway.
Int J Cancer. 128: 1966-80. -
Suck, G. et al. (2005) KHYG-1, a model for the study of enhanced natural killer cell cytotoxicity.
Exp Hematol. 33: 1160-71. -
Vrazo, A.C. et al. (2015) Live cell evaluation of granzyme delivery and death receptor signaling in tumor cells targeted by human natural killer cells.
Blood. 126 (8): e1-e10. -
Korten, S. et al. (2008) Natural death of adult Onchocerca volvulus and filaricidal effects of doxycycline induce local FOXP3+/CD4+ regulatory T cells and granzyme expression.
Microbes Infect. 10 (3): 313-24.
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