FRIZZLED-5 antibody | CD02-3B3
Mouse anti Human FRIZZLED-5
- Product Type
- Monoclonal Antibody
- Clone
- CD02-3B3
- Isotype
- IgG1
- Specificity
- FRIZZLED-5
Antibody Quality and Performance Guarantee
| Mouse anti human Frizzled-5, clone CD02-3B3 recognizes the Frizzled-5 protein, also known as FZD5 or C2orf31. Frizzled proteins are G-protein coupled receptors which have the ability to bind to WNT ligands. When FZD5 is bound to WNT ligand WNT7A, the resulting signals induce an increase in endometrial and ovarian cell cancer proliferation and growth via the β-catenin pathway. (Dong et al. 2021). |
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Rat - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- E. coli-derived recombinant protein, aa 27-238 of human Frizzled-5
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Western Blotting |  |
1/2000 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Western Blotting
- Mouse anti Human Frizzled-5 antibody detects a band of 61 kDa in HepG2 cell lysates
- UniProt
- Q13467
- Entrez Gene
- FZD5
- GO Terms
- GO:0005886 plasma membrane
- GO:0000139 Golgi membrane
- GO:0001525 angiogenesis
- GO:0006915 apoptosis
- GO:0016021 integral to membrane
- GO:0042813 Wnt receptor activity
- GO:0004930 G-protein coupled receptor activity
- GO:0007409 axonogenesis
- GO:0007420 brain development
- View More GO Terms
- GO:0008406 gonad development
- GO:0008595 anterior/posterior axis specification, embryo
- GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
- GO:0017147 Wnt-protein binding
- GO:0030165 PDZ domain binding
- GO:0031076 embryonic camera-type eye development
- GO:0031077 post-embryonic camera-type eye development
- GO:0032729 positive regulation of interferon-gamma production
- GO:0033077 T cell differentiation in thymus
- GO:0042995 cell projection
- GO:0060061 Spemann organizer formation
- GO:0060070 canonical Wnt receptor signaling pathway
- GO:0060716 labyrinthine layer blood vessel development
- GO:0071219 cellular response to molecule of bacterial origin
MCA6421GA
100007686
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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