Desmoplakin 1/2 antibody | DP-2.15

Mouse anti Desmoplakin 1/2

Product Type
Monoclonal Antibody
Clone
DP-2.15
Isotype
IgG1
Specificity
Desmoplakin 1/2

Product Code Applications Pack Size List Price Your Price Qty
2722-5204
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SDS Safety Datasheet SDS
C IF WB 50 µg loader
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loader
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Mouse anti Desmoplakin 1/2 antibody, clone DP-2.15 recognizes both desmoplakin 1 and 2 from stratified epithelia, simple epithelia including glands, urothelium, thymic reticular epithelium, hepatocytes, intercalated disks of myocardium and arachnoid cells of meninges. Mouse anti Desmoplakin 1/2 antibody, clone DP-2.15 can be used for the detection of primary and metastatic carcinomas.
Mouse anti Desmoplakin 1/2 antibody, clone DP-2.15 recognizes the N terminus of the rod domain of desmoplakin ( Bornslaeger et al. 1996).

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Bovine
Chicken
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
<0.1% Sodium Azide (NaN3)
Immunogen
Native bovine desmoplakin 1 and 2 purified from bovine snout desmosomes.
Approx. Protein Concentrations
IgG concentration 1mg/ml
Fusion Partners
Spleen cells from immunized Balb/c mice were fused with cells from the NS0 mouse myeloma cell line.
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Immunofluorescence
Immunohistology - Frozen
Western Blotting
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.

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References for Desmoplakin 1/2 antibody

  1. Cowin, P. et al. (1985) The complement of desmosomal plaque proteins in different cell types.
    J Cell Biol. 101 (4): 1442-54.
  2. Jheon, A.H. et al. (2011) PERP regulates enamel formation via effects on cell-cell adhesion and gene expression.
    J Cell Sci. 124: 745-54.
  3. Bornslaeger, E.A. et al. (1996) Breaking the connection: displacement of the desmosomal plaque protein desmoplakin from cell-cell interfaces disrupts anchorage of intermediate filament bundles and alters intercellular junction assembly.
    J. Cell. Biol. 134: 985-1001.
  4. Park, D.S. et al. (2015) Genetically engineered SCN5A mutant pig hearts exhibit conduction defects and arrhythmias.
    J Clin Invest. 125 (1): 403-12.
  5. DeQuach JA et al. (2010) Simple and high yielding method for preparing tissue specific extracellular matrix coatings for cell culture.
    PLoS One. 5 (9): e13039.
  6. Basheer, W.A. et al. (2015) Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis.
    J Mol Cell Cardiol. 88: 1-13.
  7. Yung, H.W. et al. (2016) Placental endoplasmic reticulum stress in gestational diabetes: the potential for therapeutic intervention with chemical chaperones and antioxidants.
    Diabetologia. 59 (10): 2240-50.
  8. Chkourko, H.S. et al. (2012) Remodeling of mechanical junctions and of microtubule-associated proteins accompany cardiac connexin43 lateralization.
    Heart Rhythm. 9 (7): 1133-1140.e6.
  9. View The Latest Product References
  10. Vila, J. et al. (2017) Structural and molecular pathology of the atrium in boxer arrhythmogenic right ventricular cardiomyopathy.
    J Vet Cardiol. 19 (1): 57-67.
  11. Yung, H.W. et al. (2016) Placental endoplasmic reticulum stress in gestational diabetes: the potential for therapeutic intervention with chemical chaperones and antioxidants.
    Diabetologia. 59 (10): 2240-50.
  12. Papageorgiou, I. et al. (2014) Interaction of micron and nano-sized particles with cells of the dura mater.
    J Biomed Mater Res B Appl Biomater. 102 (7): 1496-505.
  13. Otten, J. et al. (2010) Complete loss of murine Xin results in a mild cardiac phenotype with altered distribution of intercalated discs.
    Cardiovasc Res. 85 (4): 739-50.

Immunofluorescence

RRID
AB_619950
UniProt
P15924
Entrez Gene
DSP
GO Terms
GO:0001533 cornified envelope
GO:0030674 protein binding, bridging
GO:0005200 structural constituent of cytoskeleton
GO:0006921 cellular component disassembly involved in apoptosis
GO:0018149 peptide cross-linking
GO:0030057 desmosome
GO:0030216 keratinocyte differentiation
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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