Desmoplakin 1/2 antibody | DP-2.15
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Mouse anti Desmoplakin 1/2
- Product Type
- Monoclonal Antibody
- Desmoplakin 1/2
|Mouse anti Desmoplakin 1/2 antibody, clone DP-2.15 recognizes both desmoplakin 1 and 2 from stratified epithelia, simple epithelia including glands, urothelium, thymic reticular epithelium, hepatocytes, intercalated disks of myocardium and arachnoid cells of meninges. Mouse anti Desmoplakin 1/2 antibody, clone DP-2.15 can be used for the detection of primary and metastatic carcinomas.
Mouse anti Desmoplakin 1/2 antibody, clone DP-2.15 recognizes the N terminus of the rod domain of desmoplakin ( Bornslaeger et al. 1996).
- Target Species
- Species Cross-Reactivity
Target Species Cross Reactivity Bovine Chicken Mouse Rat
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Native bovine desmoplakin 1 and 2 purified from bovine snout desmosomes.
- Approx. Protein Concentrations
- IgG concentration 1mg/ml
- Fusion Partners
- Spleen cells from immunized Balb/c mice were fused with cells from the NS0 mouse myeloma cell line.
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen|
References for Desmoplakin 1/2 antibody
Cowin, P. et al. (1985) The complement of desmosomal plaque proteins in different cell types.
J Cell Biol. 101 (4): 1442-54.
Otten, J. et al. (2010) Complete loss of murine Xin results in a mild cardiac phenotype with altered distribution of intercalated discs.
Cardiovasc Res. 85 (4): 739-50.
DeQuach JA et al. (2010) Simple and high yielding method for preparing tissue specific extracellular matrix coatings for cell culture.
PLoS One. 5 (9): e13039.
Jheon, A.H. et al. (2011) PERP regulates enamel formation via effects on cell-cell adhesion and gene expression.
J Cell Sci. 124: 745-54.
Chkourko, H.S. et al. (2012) Remodeling of mechanical junctions and of microtubule-associated proteins accompany cardiac connexin43 lateralization.
Heart Rhythm. 9 (7): 1133-1140.e6.
Papageorgiou, I. et al. (2014) Interaction of micron and nano-sized particles with cells of the dura mater.
J Biomed Mater Res B Appl Biomater. 102 (7): 1496-505.
Basheer, W.A. et al. (2015) Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis.
J Mol Cell Cardiol. 88: 1-13.
Park, D.S. et al. (2015) Genetically engineered SCN5A mutant pig hearts exhibit conduction defects and arrhythmias.
J Clin Invest. 125 (1): 403-12.
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Yung, H.W. et al. (2016) Placental endoplasmic reticulum stress in gestational diabetes: the potential for therapeutic intervention with chemical chaperones and antioxidants.
Diabetologia. 59 (10): 2240-50.
Vila, J. et al. (2017) Structural and molecular pathology of the atrium in boxer arrhythmogenic right ventricular cardiomyopathy.
J Vet Cardiol. 19 (1): 57-67.
- Entrez Gene
- GO Terms
- GO:0001533 cornified envelope
- GO:0030674 protein binding, bridging
- GO:0005200 structural constituent of cytoskeleton
- GO:0006921 cellular component disassembly involved in apoptosis
- GO:0018149 peptide cross-linking
- GO:0030057 desmosome
- GO:0030216 keratinocyte differentiation
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