DAXX antibody | DAXX-01
Mouse anti Human DAXX
- Product Type
- Monoclonal Antibody
- Clone
- DAXX-01
- Isotype
- IgG1
- Specificity
- DAXX
Mouse anti Human DAXX antibody, clone DAXX-01 recognizes human Death domain-associated protein 6, also known as DAXX, ETS1-associated protein 1, EAP1 or Fas death domain-associated protein. DAXX is a 740 amino acid ~81 kDa nucleoplasmic protein. DAXX is a regulator of apoptosis implicated in Fas and TGF beta induced apoptosis. DAXX is predominantly a nuclear protein, where it as a repressor of EtsI and Pax3 transactivation. When in association with ASK1 kinase DAXX translocates from the nucleus to the cytoplasm. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- < 0.1% sodium azide (NaN3)
- Immunogen
- Recombinant C-terminal DAXX protein (aa 558-740).
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Immunofluorescence | |||
Immunohistology - Frozen | |||
Western Blotting |
References for DAXX antibody
-
Boehrer, S. et al. (2005) Daxx overexpression in T-lymphoblastic Jurkat cellsenhances caspase-dependent death receptor- and drug-induced apoptosis in distinct ways.
Cell Signal. 17:581-95. -
Tavalai, N. et al. (2006) Evidence for a role of the cellular ND10 protein PML in mediating intrinsic immunity against human cytomegalovirus infections.
J Virol. 80: 8006-18. -
Sourvinos, G. et al. (2007) Recruitment of human cytomegalovirus immediate-early 2 protein onto parental viral genomes in association with ND10 in live-infected cells.
J Virol. 81: 10123-36. -
Tavalai, N. et al. (2008) Insertion of an EYFP-pp71 (UL82) coding sequence into the human cytomegalovirus genome results in a recombinant virus with enhanced viral growth.
J Virol. 82: 10543-55. -
Full, F. et al. (2012) Herpesvirus saimiri antagonizes nuclear domain 10-instituted intrinsic immunity via an ORF3-mediated selective degradation of cellular protein Sp100.
J Virol. 86 (7): 3541-53. -
Full, F. et al. (2014) Kaposi's Sarcoma Associated Herpesvirus Tegument Protein ORF75 Is Essential for Viral Lytic Replication and Plays a Critical Role in the Antagonization of ND10-Instituted Intrinsic Immunity.
PLoS Pathog. 10(1):e1003863. -
Brown, J.R. et al. (2016) SUMO Ligase Protein Inhibitor of Activated STAT1 (PIAS1) Is a Constituent Promyelocytic Leukemia Nuclear Body Protein That Contributes to the Intrinsic Antiviral Immune Response to Herpes Simplex Virus 1.
J Virol. 90 (13): 5939-52.
- Synonyms
- Death DOMAIN-ASSOCIATED Protein 6
- RRID
- AB_2088900
- UniProt
- Q9UER7
- Entrez Gene
- DAXX
- GO Terms
- GO:0000775 chromosome, centromeric region
- GO:0002039 p53 binding
- GO:0006915 apoptosis
- GO:0005057 receptor signaling protein activity
- GO:0005730 nucleolus
- GO:0006350 transcription
- GO:0007257 activation of JUN kinase activity
- GO:0008134 transcription factor binding
- GO:0008625 induction of apoptosis via death domain receptors
- View More GO Terms
- GO:0016481 negative regulation of transcription
- GO:0016605 PML body
- GO:0031072 heat shock protein binding
- GO:0030521 androgen receptor signaling pathway
- GO:0031396 regulation of protein ubiquitination
- GO:0031625 ubiquitin protein ligase binding
- GO:0042803 protein homodimerization activity
- GO:0044419 interspecies interaction between organisms
- GO:0045892 negative regulation of transcription, DNA-dependent
- GO:0047485 protein N-terminus binding
- GO:0050681 androgen receptor binding
MCA2143
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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