CXCL16 antibody | B06-3H6
Mouse anti Human CXCL16
- Product Type
- Monoclonal Antibody
- Clone
- B06-3H6
- Isotype
- IgG1
- Specificity
- CXCL16
Antibody Quality and Performance Guarantee
| Mouse anti Human CXCL16 antibody, clone B06-3H6, recognizes C-X-C motif Chemokine 16 (CXCL16). Unlike most chemokines, CXCL16 is a membrane bound ligand anchored through transmembrane domains. Although a soluble form of CXCL16 is generated through proteolytic cleavage. Transmembrane CXCL16 is mainly expressed on macrophages, dendritic cells, B cells and various tumor cells. In this form, it acts as an adhesion molecule though the binding of its receptor CXCR6 expressed on other cells including T cells. Transmembrane CXCL16 also binds gram positive and gram negative bacteria, playing a role in innate and adaptive immune responses (Shimaoka et al. 2003). Soluble CXCL16 has chemoattractant activity, and elicits this response through the receptor CXCR6. CXCL16 may also play a role in tumor progression and serve as a biomarker for the evaluation of some tumor type prognoses (Richardsen et al. 2015, Shibata et al. 2020, Gooden et al. 2014). The purified Mouse anti Human CXCL16 antibody, clone B06-3H6 (MCA6222GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human CXCL16 antibody, clone C19-5F9 (MCA6223B) as the detection antibody. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Carrier Free
- Yes
- Immunogen
- E. coli derived recombinant human full length CXCL16 (Asn49-Pro137)
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Cell fusion between immunized BALB/c mouse spleen cells and mouse myeloma SP2/0
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
1.0 ug/ml |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse anti Human CXCL16:Biotin | MCA6223B | E | 0.1 mg |
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| Description | Mouse anti Human CXCL16:Biotin | ||||||
- UniProt
- Q9H2A7
- Entrez Gene
- CXCL16
- GO Terms
- GO:0005886 plasma membrane
- GO:0016021 integral to membrane
- GO:0005041 low-density lipoprotein receptor activity
- GO:0005044 scavenger receptor activity
- GO:0005615 extracellular space
- GO:0006898 receptor-mediated endocytosis
- GO:0008009 chemokine activity
- GO:0030307 positive regulation of cell growth
- GO:0030335 positive regulation of cell migration
- View More GO Terms
- GO:0034341 response to interferon-gamma
- GO:0034612 response to tumor necrosis factor
- GO:0048247 lymphocyte chemotaxis
MCA6222GA
100005284
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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