Complement Factor P antibody | 062-260 (10-24)
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Mouse anti Human Factor P
- Product Type
- Monoclonal Antibody
- Clone
- 062-260 (10-24)
- Isotype
- IgG1
- Specificity
- Complement Factor P
Antibody Quality and Performance Guarantee
| Mouse anti Human complement factor P antibody, clone 062-260 (10-24) recognises human complement factor P, a 53 kDa glycosylated protein present in serum. Factor P binds to microbial surfaces and binds and stabilizes the complement component 3- and complement component 5-convertase enzyme complexes. C3b then acts as an opsonin or initiates the complement pathway again creating a positive feedback loop which acts only on the bacterial cell, leaving the host cells unharmed. Deficiency of factor P makes the host more susceptible to bacterial infections, particularly to Neisseria species and meningococcal infections. Mouse anti Human complement factor P antibody, clone 10-24 does not inhibit function of complement factor P. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from ascites
- Buffer Solution
- Borate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Purified Human factor P from human serum.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- Guaranteed until date of expiry. Please see product label.
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
||
| Functional Assays | |||
| Immunohistology - Frozen | |
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| Western Blotting | |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Histology Positive Control Tissue
- Kidney from post streptoccal glomerulonephritis patients
Further Reading
-
Hourcade, D.E. (2006) The role of properdin in the assembly of the alternative pathway C3 convertases of complement.
J Biol Chem. 281 (4): 2128-32. -
Jelezarova, E. et al. (2000) Interaction of C3b(2)--IgG complexes with complement proteins properdin, factor B and factor H: implications for amplification.
Biochem J. 349 (Pt 1): 217-23.
- Synonyms
- Properdin
- RRID
- AB_844543
- UniProt
- P27918
- Entrez Gene
- CFP
- GO Terms
- GO:0042742 defense response to bacterium
- GO:0005615 extracellular space
- GO:0006957 complement activation, alternative pathway
MCA2618
153544
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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