Complement Factor I antibody | 052.11.3 (3R/8)
|Mouse anti Human Complement Factor I antibody, clone 052.11.3 (3R/8) recognizes complement factor I, a member of the peptidase S1 family present in the blood plasma. Factor I is an 88 kDa protein consisting of one polypeptide chain of 35.4 kDa and one of 27.6 kDa. Factor I is a serine protease which inactivates complement components C3b and C4b. C3b cleavage requires the presence of cofactors complement component (3b/4b) receptor 1 (CR1), membrane cofactor protein or factor H, while C4b cleavage requires complement component 4 binding protein or CR1. Factor I has no natural inhibitors.
Dysfunctional factor I can lead to uncontrolled activation of the alternative complement pathway causing in systemic depletion of C3 and lower levels of factors B and H, resulting in recurrent pyogenic infections. Defects in CFI are also associated with haemolytic uraemic syndrome.
Mouse anti Human Complement Factor I antibody, clone 3R/8 blocks function of complement factor I.
Removal of Sodium Azide is recommended prior to use in functional assays.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein A
- Buffer Solution
- Borate buffered saline
- Preservative Stabilisers
0.1% Sodium Azide (NaN3)
- Native human factor I from serum.
- Approx. Protein Concentrations
- Current, batch-specific concentration 1.20 mg/ml
- For research purposes only
- Guaranteed until date of expiry. Please see product label.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen|
- Histology Positive Control Tissue
- Kidney from post streptoccal glomerulonephritis patients
References for Complement Factor I antibody
Dragon-Durey, M.A. & Frémeaux-Bacchi, V. (2005) Atypical haemolytic uraemic syndrome and mutations in complement regulator genes.
Springer Semin Immunopathol. 27 (3): 359-74.
Nilsson, S.C. et al. (2007) A mutation in factor I that is associated with atypical hemolytic uremic syndrome does not affect the function of factor I in complement regulation.
Mol Immunol. 44 (8): 1835-44.
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