Complement Factor H antibody | 028B-244.2.10X (10-10)
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Mouse anti Human Complement Factor H
- Product Type
- Monoclonal Antibody
- Clone
- 028B-244.2.10X (10-10)
- Isotype
- IgG1
- Specificity
- Complement Factor H
Antibody Quality and Performance Guarantee
| Mouse anti Human Complement Factor H antibody, clone 028B-244.2.10X (10-10) recognizes human complement factor H which exists in 2 forms. The most common form, of 150 kDa, and the less common form of 43 kDa. Factor H is secreted by the liver into the blood serum. It is important in regulating the complement pathway, preventing unnecessary inflammation which can damage the host tissue. Complement factor H functions as a cofactor in the inactivation of C3b by factor I. It makes C3b susceptible to cleavage by factor I, resulting in iC3b. Factor H also inhibits the formation of the C3bBb complex (C3 convertase) and increases the rate of dissociation of both C3 convertase and the (C3b)NBB complex (C5 convertase). This prevents these components of the classical and of alternative complement pathways from forming a positive feedback loop. Mutations in factor H are associated with hemolytic-uremic syndrome, age-related macular degeneration, membranoproliferative glomerulonephritis (MPGN) type II and chronic hypocomplementemic nephropathy. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from ascites
- Buffer Solution
- Borate buffered saline
- Preservative Stabilisers
- 0.1% Sodium Azide (NaN3)
- Immunogen
- Purified human complement factor H from serum.
- Approx. Protein Concentrations
- Current, batch-specific concentration 1.11 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- Guaranteed until date of expiry. Please see product label.
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
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| Flow Cytometry | |
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| Immunohistology - Frozen | |
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| Western Blotting | |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Histology Positive Control Tissue
- Kidney from post streptococcal glomerulonephritis patients.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse IgG1 Negative Control | MCA928 | F | 100 Tests |
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| List Price | Your Price | ||||||
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| Description | Mouse IgG1 Negative Control | ||||||
Further Reading
-
Alexander JJ & Quigg RJ (2007) The simple design of complement factor H: Looks can be deceiving.
Mol Immunol. 44 (1-3): 123-32. -
Harrison, R.A. & Lachmann, P.J. (1980) The physiological breakdown of the third component of human complement.
Mol Immunol. 17 (1): 9-20.
- Synonyms
- H Factor 1
- RRID
- AB_2260573
- UniProt
- P08603
- Entrez Gene
- CFH
MCA2614
146284
157760
158318
162579
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
View more products with COMPLEMENT FACTOR specificity
Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"
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