Chymotrypsin antibody | CHYMO10-104.5 (4E1)

Mouse anti Human Chymotrypsin

Product Type
Monoclonal Antibody
Clone
CHYMO10-104.5 (4E1)
Isotype
IgG3
Specificity
Chymotrypsin

Product Code Applications Pack Size List Price Your Price Qty
2100-0657
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C E IF P WB 0.2 mg loader
List Price Your Price
loader
Search for Batch Specific Datasheets

Mouse anti Human chymotrypsin antibody, clone 4E1 recognizes human chymotrypsin-C, also known as chymotrypsin or caldecrin. Chymotrypsin is a 239 amino acid ~30 kDa protease with an additional 13 amino acid propeptide region and a 16 amino acid signal peptide.

Variations in the CTRC gene has been associated with susceptibility to hereditary, pancreatitis (PCTT), a disease characterized by pancreatic inflammation and destruction of the parenchyma (Beer et al. 2013).

Target Species
Human
Species Cross-Reactivity
Target SpeciesCross Reactivity
Mouse
Rat
N.B. Antibody reactivity and working conditions may vary between species.
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein G from ascites
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
<0.1% Sodium Azide (NaN3)
Immunogen
Purified human pancreatic chymotrypsin.
Approx. Protein Concentrations
IgG concentration 1.0 mg/ml
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
ELISA
Immunofluorescence
Immunohistology - Frozen
Immunohistology - Paraffin
Western Blotting
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.

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References for Chymotrypsin antibody

  1. Jimenez, R.E. et al. (1999) Immunohistochemical characterization of pancreatic tumors induced by dimethylbenzanthracene in rats.
    Am J Pathol. 154 (4): 1223-9.
  2. Larina, O.et al. (2007) Dynamic regulation of the large exocytotic fusion pore in pancreatic acinar cells.
    Mol Biol Cell. 18:3502-11.
  3. Bockman, D.E. et al. (2003) Origin and development of the precursor lesions in experimental pancreatic cancer in rats.
    Lab Invest. 83 (6): 853-9.
  4. Li, H. et al. (2009) The Ink4/Arf locus is a barrier for iPS cell reprogramming.
    Nature. 460: 1136-9.
  5. Vincent, D.F. et al. (2009) Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas.
    PLoS Genet. 5: e1000575.
  6. Behrendorff, N. et al. (2011) Vesicle-associated membrane protein 8 (VAMP8) is a SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) selectively required for sequential granule-to-granule fusion.
    J Biol Chem. 286 (34): 29627-34.
  7. Guerra, C. et al. (2011) Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence.
    Cancer Cell. 19: 728-39.
  8. Kanayama, K. et al. (2016) Cytological findings of an ectopic pancreas of the stomach obtained at endoscopic ultrasound-guided fine needle aspiration, differential diagnosis from acinar cell carcinoma: a case report.
    Cytopathology. 27 (5): 379-81.
  9. View The Latest Product References
  10. Vincent DF et al. (2012) Tif1γ suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway.
    Am J Pathol. 180 (6): 2214-21.
  11. Kato, Y. et al. (2014) Ectopic tissue consisting of a mixture of glandular gastric, intestinal, and exocrine pancreatic tissue in the forestomach of a rat.
    J Toxicol Pathol. 27 (1): 87-90.
  12. Bansal, S. et al.. (2015) Multilocular Pancreatic Acinar Cystadenoma Containing Areas of Multifocal Branch-Duct Intraductal Papillary Mucinous Neoplasm
    J. Pancreas 15 (5): 475-80.

Immunofluorescence

Immunohistology - Frozen

Immunohistology - Paraffin

RRID
AB_2261171
UniProt
Q99895
Entrez Gene
CTRC
GO Terms
GO:0004252 serine-type endopeptidase activity
GO:0006508 proteolysis
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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