CD84 antibody | CD84.1.21
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F ResetMouse anti Human CD84
- Product Type
- Monoclonal Antibody
- Clone
- CD84.1.21
- Isotype
- IgG1
- Specificity
- CD84
Antibody Quality and Performance Guarantee
| Mouse anti Human CD84 antibody, clone CD84.1.21 recognizes human SLAM family member 5, also known as CD84, Cell surface antigen MAX.3, Hly9-beta or Signaling lymphocytic activation molecule 5. CD84 is a highly glycosylated cell surface antigen of ~64-82 kDa, predominantly expressed by B lymphocytes, monocytes and macrophages, although lower levels of expression have also been reported on T cells, granulocytes and platelets. Mouse anti Human CD84 antibody, clone CD84.1.21 has been shown to partially block CD84 homophilic binding (Moore et al. 2001). |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% sodium azide (NaN3)
- Carrier Free
- Yes
- Immunogen
- Mouse pre-B cell line 300.19 transfected with CD84 cDNA.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS-1 myeloma cell line.
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry |  |
1/25 | 1/100 |
| Immunoprecipitation | |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10μl of the suggested working dilution to label 106 cells or 100μl whole blood
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse IgG1 Negative Control | MCA928 | F | 100 Tests |
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| List Price | Your Price | ||||||
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| Description | Mouse IgG1 Negative Control | ||||||
Source Reference
-
Martin, M. et al. (2001) CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1.
J Immunol. 167 (7): 3668-76.
References for CD84 antibody
-
Romero, X. et al. (2005) CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse.
J Immunol. 174 (11): 7033-42. -
Sayós J et al. (2001) Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP.
Blood. 97 (12): 3867-74. -
Mihalache, C.C. et al. (2011) Inflammation-associated autophagy-related programmed necrotic death of human neutrophils characterized by organelle fusion events.
J Immunol. 186: 6532-42. -
Wang, X. et al. (2016) Neutrophil Necroptosis Is Triggered by Ligation of Adhesion Molecules following GM-CSF Priming.
J Immunol. 197 (10): 4090-100.
MCA2123
148427
1806
If you cannot find the batch/lot you are looking for please contact our technical support team for assistance.
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