CD26 antibody | rA13B13-08/4C8
Mouse anti Human CD26
- Product Type
- Monoclonal Antibody
- Clone
- rA13B13-08/4C8
- Isotype
- IgG1
- Specificity
- CD26
Antibody Quality and Performance Guarantee
TZA076GA
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| Mouse anti Human CD26 antibody, clone rA13B13-08/4C8, is a recombinant monoclonal antibody that recognizes CD26, also known as dipeptidyl peptidase 4 (DPP4) or adenosine deaminase complexing protein 2. CD26 is a single pass type II transmembrane glycoprotein expressed by activated T cells, B cells, natural killer cells and myeloid cells. A soluble form of CD26 can be derived by cleavage of the membrane bound form between residues 38-39. CD26 has DPP4 activity, cleaving off amino-terminal dipeptides with either L-alanine or L-proline in the second position. CD26 also interacts with a variety of binding partners, including Caveolin-1 and CXCR4. In the immune system, CD26 has a role in T cell development and activation. CD26 is involved in immune-mediated disorders, including rheumatoid arthritis and graft-versus-host disease (GVHD). CD26 expression has been associated with more aggressive variants in certain cancers through the regulation of metastasis and local invasion. CD26 absence has also been linked to the development of other cancers due to its ability to regulate cancer progression. CD26 is the functional receptor for the pathogenic Middle East respiratory syndrome coronavirus. |
- Target Species
- Human
- Product Form
- Purified recombinant IgG containing a SpyTag at the C-terminus of the antibody heavy chain – liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Source
- CHO cells
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- Recombinant CD26 Asn29-Pro766 expressed by mammalian cells
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- 12 months from date of despatch
- Acknowledgements
- This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry |  |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 5μl of the suggested working dilution to label 0.5x106 cells in 100μl. Best practices suggest a 5 min centrifugation at 6,000g prior to sample application.
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse IgG1 Negative Control | MCA928 | F | 100 Tests |
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| Description | Mouse IgG1 Negative Control | ||||||
- Synonyms
- ADCP-2
- Dipeptidyl Peptidase 4
- UniProt
- P27487
- Entrez Gene
- DPP4
- GO Terms
- GO:0001666 response to hypoxia
- GO:0002020 protease binding
- GO:0004252 serine-type endopeptidase activity
- GO:0004177 aminopeptidase activity
- GO:0008239 dipeptidyl-peptidase activity
- GO:0005102 receptor binding
- GO:0007155 cell adhesion
- GO:0016021 integral to membrane
- GO:0005576 extracellular region
- View More GO Terms
- GO:0004872 receptor activity
- GO:0030139 endocytic vesicle
- GO:0006508 proteolysis
- GO:0008284 positive regulation of cell proliferation
- GO:0009986 cell surface
- GO:0010716 negative regulation of extracellular matrix disassembly
- GO:0016324 apical plasma membrane
- GO:0031258 lamellipodium membrane
- GO:0031295 T cell costimulation
- GO:0033632 regulation of cell-cell adhesion mediated by integrin
- GO:0042110 T cell activation
- GO:0042803 protein homodimerization activity
- GO:0043542 endothelial cell migration
- GO:0045121 membrane raft
- GO:0071438 invadopodium membrane
TZA076GA
64714515
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