CD26 antibody | M-A261
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|Mouse anti Human CD26 antibody, clone M-A261, recognizes human dipeptidyl peptidase 4, also known as adenosine deaminase complexing protein 2, CD26, TP103, ADABP or DPP IV. CD26 is a 766 amino acid ~110 kDa single pass type II transmembrane glycoprotein expressed by activated T cells, B cells and macrophages. A soluble form of CD26 can be derived by cleavage of the membrane bound form between residues 38-39 (Uniprot: 27487).
CD26 acts as a functional receptor for the pathogenic Middle East respiratory syndrome coronavirus [MERS-CoV] (Raj et al. 2014), a severe and frequently fatal disease in humans and marmosets sharing identical CD26 sequence at the site of interaction with the MERS-CoV spike protein (Lu et al. 2013, Wang et al. 2013).
Mouse anti Human CD26 antibody, clone M-A261 has been used successfully for the immunohistochemical detection of CD26 on formalin fixed, paraffin embedded tissues and the demonstration of elevated CD26 expression in thyroid neoplasia (Kholová et al. 2003). Mouse anti Human CD26 antibody, clone M-A261 has also been used for the immunohistochemical detection of CD26 on cryostat sections using both immunoperoxidase and immunofluorescence staining in liver biopsies from NASH patients (Balaban et al. 2007).
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% sodium azide (NaN3)
- Carrier Free
- Human T-cell leukemia cells (T-CLL)
- Approx. Protein Concentrations
- IgG concentration 1 mg/ml
- Fusion Partners
- Spleen cells from immunised BALB/c mice were fused with cells of the mouse P3.X63 Ag8.653 myeloma cell line
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen 1|
|Immunohistology - Paraffin|
- 1The epitope recognised by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. Bio-Rad recommends the use of acetone fixation for frozen sections.
- Flow Cytometry
- Use 10μl of the suggested working dilution to label 106 cells or 100μl whole blood
- Histology Positive Control Tissue
References for CD26 antibody
Berg, L.P. et al. (2002) Functional consequences of noncognate interactions between CD4+ memory T lymphocytes and the endothelium.
J Immunol. 168 (7): 3227-34.
Post, S. et al. (2010) Impaired recruitment of HHT-1 mononuclear cells to the ischaemic heart is due to an altered CXCR4/CD26 balance.
Cardiovasc Res. 85: 494-502.
Balaban, Y.H. et al. (2007) Dipeptidyl peptidase IV (DDP IV) in NASH patients.
Ann Hepatol. 6: 242-50.
Krijnen, P.A. et al. (2012) Loss of DPP4 activity is related to a prothrombogenic status of endothelial cells: implications for the coronary microvasculature of myocardial infarction patients.
Basic Res Cardiol. 107: 233.
Kholová, I. et al. (2003) Immunohistochemical detection of dipeptidyl peptidase IV (CD 26) in thyroid neoplasia using biotinylated tyramine amplification.
Neoplasma. 50: 159-64.
Lutz, M.S. and Burk, R.D. (2006) Primary cilium formation requires von hippel-lindau gene function in renal-derived cells.
Cancer Res. 66: 6903-7.
(2003) Anergic T cells exert antigen-independent inhibition of cell-cell interactions via chemokine metabolism.
Snooks, M.J. et al. (2008) Vectorial entry and release of hepatitis A virus in polarized human hepatocytes.
J Virol. 82: 8733-42.
View The Latest Product References
Sun, A.L. et al. (2012) Dipeptidyl peptidase-IV is a potential molecular biomarker in diabetic kidney disease.
Diab Vasc Dis Res. 9: 301-8.
Le Naour, F. et al. (2006) Profiling of the tetraspanin web of human colon cancer cells.
Mol Cell Proteomics. 5: 845-57.
Akilov, O.E. et al. (2012) Resistance of Sézary cells to TNF-α-induced apoptosis is mediated in part by a loss of TNFR1 and a high level of the IER3 expression.
Exp Dermatol. 21: 287-92.
- Entrez Gene
- GO Terms
- GO:0001666 response to hypoxia
- GO:0002020 protease binding
- GO:0004252 serine-type endopeptidase activity
- GO:0004177 aminopeptidase activity
- GO:0008239 dipeptidyl-peptidase activity
- GO:0005102 receptor binding
- GO:0007155 cell adhesion
- GO:0016021 integral to membrane
- GO:0005576 extracellular region
- View More GO Terms
- GO:0004872 receptor activity
- GO:0030139 endocytic vesicle
- GO:0006508 proteolysis
- GO:0008284 positive regulation of cell proliferation
- GO:0009986 cell surface
- GO:0010716 negative regulation of extracellular matrix disassembly
- GO:0016324 apical plasma membrane
- GO:0031258 lamellipodium membrane
- GO:0031295 T cell costimulation
- GO:0033632 regulation of cell-cell adhesion mediated by integrin
- GO:0042110 T cell activation
- GO:0042803 protein homodimerization activity
- GO:0043542 endothelial cell migration
- GO:0045121 membrane raft
- GO:0071438 invadopodium membrane
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