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CD25 antibody | MEM-181

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Anti Human CD25 Antibody, clone MEM-181 thumbnail image 1 Anti Human CD25 Antibody, clone MEM-181 thumbnail image 2 Anti Human CD25 Antibody, clone MEM-181 thumbnail image 3 Anti Human CD25 Antibody, clone MEM-181 thumbnail image 4 Anti Human CD25 Antibody, clone MEM-181 thumbnail image 5 Anti Human CD25 Antibody, clone MEM-181 thumbnail image 6 Anti Human CD25 Antibody, clone MEM-181 thumbnail image 7 Anti Human CD25 Antibody, clone MEM-181 thumbnail image 8 Anti Human CD25 Antibody, clone MEM-181 thumbnail image 9 Anti Human CD25 Antibody, clone MEM-181 thumbnail image 10 Anti Human CD25 Antibody, clone MEM-181 thumbnail image 11 Anti Human CD25 Antibody, clone MEM-181 thumbnail image 12 Anti Human CD25 Antibody, clone MEM-181 thumbnail image 13 Anti Human CD25 Antibody, clone MEM-181 thumbnail image 14 Anti Human CD25 Antibody, clone MEM-181 thumbnail image 15 Anti Human CD25 Antibody, clone MEM-181 thumbnail image 16 Anti Human CD25 Antibody, clone MEM-181 thumbnail image 17 Anti Human CD25 Antibody, clone MEM-181 thumbnail image 18 Anti Human CD25 Antibody, clone MEM-181 thumbnail image 19 Anti Human CD25 Antibody, clone MEM-181 thumbnail image 20 Anti Human CD25 Antibody, clone MEM-181 thumbnail image 21 Anti Human CD25 Antibody, clone MEM-181 thumbnail image 22 Anti Human CD25 Antibody, clone MEM-181 thumbnail image 23 Anti Human CD25 Antibody, clone MEM-181 thumbnail image 24 Anti Human CD25 Antibody, clone MEM-181 thumbnail image 25 Anti Human CD25 Antibody, clone MEM-181 thumbnail image 26
Anti Human CD25 Antibody, clone MEM-181 gallery image 1
Figure A. Alexa®647 conjugated mouse anti human CD4 (MCA1267A647) and RPE conjugated Mouse IgG1 isotype control (MCA928PE). Figure B. Alexa®647 conjugated mouse anti human CD4 (MCA1267A647) and RPE conjugated mouse anti human CD25 (MCA2127PE). All experiments performed on red cell lysed human peripheral blood gated on lymphocytes in the presence of Human SeroBlock (BUF070A)
Anti Human CD25 Antibody, clone MEM-181 gallery image 2
Published customer image:
PE conjugated Mouse anti Human CD25 antibody, clone MEM-181 (MCA2127PE) used for the identification of human Tregs by flow cytometry.
Image caption:
Potency of Treg-suppression is dependent on strength of stimulus and on Effector:Treg cell (E:T) ratio. (A) Typical FACS plot displaying purity of effector (CD4+CD25−) and Treg (CD4+CD25+) populations in healthy control subjects. (B) Mean counts per minute (CPM) (+SEM) uptake of tritiated thymidine in CD25− effector T cells from healthy controls (N = 27) stimulated with mitogenic CD3/28 beads at 2:1 and 0.2:1 bead: cell ratios. (C) Mean CPM (+SEM) in CD25− effectors v CD25+ Treg cells stimulated with mitogenic CD3/28 beads at 2:1 bead: cell ratio. (D) Mean (+SEM) percentage suppression of effector cell proliferation following activation with CD3/28 beads at 2:1 (closed boxes) and 0.2:1 (open boxes) bead: cell ratios.

From: Thorborn G, Pomeroy L, Isohanni H, Perry M, Peters B, et al. (2010)
Increased Sensitivity of CD4+ T-Effector Cells to CD4+CD25+ Treg Suppression Compensates for Reduced Treg Number in Asymptomatic HIV-1 Infection.
PLoS ONE 5(2): e9254.
This image is from an open access article distributed under the terms of a Creative Commons Attribution License.
Anti Human CD25 Antibody, clone MEM-181 gallery image 3
Published customer image:
AlexaFluor®647 conjugated Mouse anti Human CD25 antibody, clone MEM-181 (MCA2127A647) used for the detection of circulating CD25 expressing cells from peripheral blood of SLE patients by flow cytometry.
Image caption:
Detection of circulating CD4+CD25low/-GITR+cells in SLE patients.(A) Flow-cytometry analysis of anti-GITR and anti-CD25-stained CD4+ T lymphocytes, freshly isolated from blood of a representative SLE patient, reveals the presence of a CD25−GITR+ cell subpopulation. Left panel: gating strategy. Gated CD4+ T lymphocytes were stained with isotype control Abs (middle panel) or anti-GITR and anti-CD25 Abs (right panel). (B) the levels of CD25 expression were evaluated in the upper left and lower left quadrants and MFI is reported. (C) mRNA expression of CD25 (FAM6 fluorochrome) in the indicated subpopulations was evaluated in quadruplicate with real-time PCR. In the same tube, expression of the housekeeping gene HPRT1 (VIC fluorochrome) was evaluated for normalization. Values of CD25 expression (striped column, CD25highGITR−; black column, CD25low/-GITR+) is shown as fold increase of mRNA levels in the positively sorted subpopulations over mRNA levels in effector (CD4+CD25−GITR−) T cells, arbitrarily set equal to 1. Data shown are mean ± SD of four SLE patients. ***P <0.001.

From: Nocentini G, Alunno A, Petrillo MG, Bistoni O, Bartoloni E, Caterbi S, Ronchetti S, Migliorati G, Riccardi C, Gerli R.
Expansion of regulatory GITR+CD25 low/-CD4+ T cells in systemic lupus erythematosus patients.
Arthritis Res Ther.2014 Sep 26;16(5):444.
This image is from an open access article distributed under the terms of a Creative Commons Attribution License.
Anti Human CD25 Antibody, clone MEM-181 gallery image 4
Figure A. Alexa Fluor 647 conjugated Mouse anti Human CD3 (MCA463A647). Figure B. Alexa Fluor 647 conjugated Mouse anti Human CD3 (MCA463A647) and SBV515 conjugated Mouse anti Human CD25 (MCA2127SBV515). All experiments performed on human PBMCs stimulated with PHA for 3 days gated on live single cell lymphocytes, in the presence of 10% human serum. Data acquired on the ZE5 Cell Analyzer.
Anti Human CD25 Antibody, clone MEM-181 gallery image 5
Figure A. Alexa Fluor 647 conjugated Mouse anti Human CD3 (MCA463A647). Figure B. Alexa Fluor 647 conjugated Mouse anti Human CD3 (MCA463A647) and StarBright Violet 670 conjugated Mouse anti Human CD25 (MCA2127SBV670). All experiments performed on human PBMCs stimulated with PHA for 3 days gated on live lymphocytes, in the presence of 10% human serum. Data acquired on the ZE5 Cell Analyzer.
Anti Human CD25 Antibody, clone MEM-181 gallery image 6
Figure A. Alexa Fluor 647 conjugated Mouse anti Human CD3 (MCA463A647). Figure B. Alexa Fluor 647 conjugated Mouse anti Human CD3 (MCA463A647) and SBV440 conjugated Mouse anti Human CD25 (MCA2127SBV440). All experiments performed on human PBMCs stimulated with PHA for 3 days gated on live single lymphocytes, in the presence of 10% human serum. Data acquired on the ZE5 Cell Analyzer.
Anti Human CD25 Antibody, clone MEM-181 gallery image 7
Figure A. Alexa Fluor 647 conjugated Mouse anti Human CD3 (MCA463A647). Figure B. Alexa Fluor 647 conjugated Mouse anti Human CD3 (MCA463A647) and StarBright Violet 610 conjugated Mouse anti Human CD25 (MCA2127SBV610). All experiments performed on human PBMCs stimulated with PHA for 3 days, gated on live single cell lymphocytes, in the presence of 10% human serum. Data acquired on the ZE5 Cell Analyzer.
Anti Human CD25 Antibody, clone MEM-181 gallery image 8
Figure A. Alexa Fluor 647 conjugated Mouse anti Human CD3 (MCA463A647). Figure B. Alexa Fluor 647 conjugated Mouse anti Human CD3 (MCA463A647) and StarBright Violet 570 conjugated Mouse anti Human CD25 (MCA2127SBV570). All experiments performed on human PBMCs stimulated with PHA for 3 days gated on live single cell lymphocytes, in the presence of 10% human serum. Data acquired on the ZE5 Cell Analyzer.
Anti Human CD25 Antibody, clone MEM-181 gallery image 9
Figure A. Alexa Fluor 488 conjugated Mouse anti Human CD3 (MCA463A488). Figure B. Alexa Fluor 488 conjugated Mouse anti Human CD3 (MCA463A488) and StarBright Violet 710 conjugated Mouse anti Human CD25 (MCA2127SBV710). All experiments performed on human PBMCs stimulated with PHA for 3 days gated on live single cell lymphocytes, in the presence of 10% human serum. Data acquired on the ZE5 Cell Analyzer.
Anti Human CD25 Antibody, clone MEM-181 gallery image 10
Figure A. Alexa Fluor 647 conjugated Mouse anti Human CD3 (MCA463A647). Figure B. Alexa Fluor 647 conjugated Mouse anti Human CD3 (MCA463A647) and StarBright Violet 790 conjugated Mouse anti Human CD25 (MCA2127SBV790). All experiments performed on PBMCs extracted from human blood stimulated with PHA for 72 hours, gated on live single cell lymphocytes, in the presence of 10% human serum. Data acquired on the ZE5 Cell Analyzer.
Anti Human CD25 Antibody, clone MEM-181 gallery image 11
Figure A. Alexa Fluor 488 conjugated Mouse anti Human CD3 (MCA463A488) . Figure B. Alexa Fluor 488 conjugated Mouse anti Human CD3 (MCA463A488) and StarBright Violet 475 conjugated Mouse anti Human CD25 (MCA2127SBV475). All experiments performed on human PBMCs stimulated with PHA for 3 days gated on live single cell lymphocytes, in the presence of 10% human serum. Data acquired on the ZE5 Cell Analyzer.
Anti Human CD25 Antibody, clone MEM-181 gallery image 12
Figure A. StarBright Violet 790 conjugated Mouse anti Human CD3 (MCA463SBV790). Figure B. StarBright Violet 790 conjugated Mouse anti Human CD3 (MCA463SBV790) and StarBright UltraViolet 400 conjugated Mouse anti Human CD25 (MCA2127SBUV400). All experiments performed on human PBMCs stimulated with PHA for 3 days, gated on live cells, in the presence of 10% human serum. Data acquired on the ZE5 Cell Analyzer.
Anti Human CD25 Antibody, clone MEM-181 gallery image 13
Figure A. StarBright Violet 440 conjugated Mouse anti Human CD3 (MCA463SBV440). Figure B. StarBright Violet 440 conjugated Mouse anti Human CD3 (MCA463SBV440) and StarBright Violet 760 conjugated Mouse anti Human CD25 (MCA2127SBV760). All experiments performed on PBMCs stimulated with PHA for 3 days gated on live single lymphocytes, in the presence of 10% human serum. Data acquired on the ZE5 Cell Analyzer.
Anti Human CD25 Antibody, clone MEM-181 gallery image 14
Figure A. Alexa Fluor 488 conjugated Mouse anti Human CD3 (MCA463A488). Figure B. Alexa Fluor 488 conjugated Mouse anti Human CD3 (MCA463A488) and StarBright UltraViolet 665 conjugated Mouse anti Human CD25 (MCA2127SBUV665). All experiments performed on human PBMCs stimulated with PHA for 3 days gated on live single cell lymphocytes, in the presence of 10% human serum. Data acquired on the ZE5 Cell Analyzer.
Anti Human CD25 Antibody, clone MEM-181 gallery image 15
Figure A. StarBright Blue 700 conjugated Mouse anti Human CD3 (MCA463SBB700). Figure B. StarBright Blue 700 conjugated Mouse anti Human CD3 (MCA463SBB700) and StarBright UltraViolet 445 conjugated Mouse anti Human CD25 (MCA21274SBUV445). All experiments performed on human PBMCs stimulated with PHA for 3 days gated on live single cell lymphocytes, in the presence of 10% human serum. Data acquired on the ZE5 Cell Analyzer.
Anti Human CD25 Antibody, clone MEM-181 gallery image 16
Figure A. FITC conjugated Mouse anti Human CD3 (MCA463F). Figure B. FITC conjugated Mouse anti Human CD3 (MCA463F) and StarBright UltraViolet 795 conjugated Mouse anti Human CD25 (MCA2127SBUV795). All experiments performed on PBMCs extracted from human blood stimulated with PHA for 72 hours, gated on live single cell lymphocytes, in the presence of 10% human serum. Data acquired on the ZE5 Cell Analyzer.
Anti Human CD25 Antibody, clone MEM-181 gallery image 17
Figure A. StarBright Violet 790 conjugated Mouse anti Human CD3 (MCA463SBV790). Figure B. StarBright Violet 790 conjugated Mouse anti Human CD3 (MCA463SBV790) and StarBright UltraViolet 510 conjugated Mouse anti Human CD25 (MCA2127SBUV510). All experiments performed on human PBMCs stimulated with PHA for 3 days gated on live single lymphocytes, in the presence of 10% human serum. Data acquired on the ZE5 Cell Analyzer.
Anti Human CD25 Antibody, clone MEM-181 gallery image 18
Figure A. StarBright Violet 440 conjugated Mouse anti Human CD3 (MCA463SBV440). Figure B. StarBright Violet 440 conjugated Mouse anti Human CD3 (MCA463SBV440) and StarBright UltraViolet 575 conjugated Mouse anti Human CD25 (MCA2127SBUV575). All experiments performed on human PBMCs stimulated with PHA for 3 days gated on live single cell lymphocytes, in the presence of 10% human serum. Data acquired on the ZE5 Cell Analyzer.
Anti Human CD25 Antibody, clone MEM-181 gallery image 19
Figure A. APC conjugated Mouse anti Human CD3 (MCA6146APC). Figure B. APC conjugated Mouse anti Human CD3 (MCA6146APC) and StarBright Blue 580 conjugated Mouse anti Human CD25 (MCA2127SBB580). All experiments performed on human PBMCs stimulated with PHA for 3 days, gated on live cells, in the presence of 10% human serum. Data acquired on the ZE5 Cell Analyzer.
Anti Human CD25 Antibody, clone MEM-181 gallery image 20
Figure A. Alexa Fluor 488 conjugated Mouse anti Human CD3 (MCA463A488). Figure B. Alexa Fluor 488 conjugated Mouse anti Human CD3 (MCA463A488) and StarBright Blue 615 conjugated Mouse anti Human CD25 (MCA2127SBB615). All experiments performed on human PBMCs stimulated with PHA for 3 days, gated on live cells, in the presence of 10% human serum. Data acquired on the ZE5 Cell Analyzer.
Anti Human CD25 Antibody, clone MEM-181 gallery image 21
Figure A. StarBright Violet 440 conjugated Mouse anti Human CD3 (MCA463SBV440). Figure B. StarBright Violet 440 conjugated Mouse anti Human CD3 (MCA463SBV440) and StarBright Blue 675 conjugated Mouse anti Human CD25 (MCA2127SBB675). All experiments performed on PBMCs stimulated with PHA for 3 days gated on live single lymphocytes, in the presence of 10% human serum. Data acquired on the ZE5 Cell Analyzer.
Anti Human CD25 Antibody, clone MEM-181 gallery image 22
Figure A. StarBright Violet 440 conjugated Mouse anti Human CD3 (MCA463SBV440). Figure B. StarBright Violet 440 conjugated Mouse anti Human CD3 (MCA463SBV440) and StarBright Blue 765 conjugated Mouse anti Human CD25 (MCA2127SBB765). All experiments performed on human PBMCs stimulated with PHA for 3 days gated on live lymphocytes, in the presence of 10% human serum. Data acquired on the ZE5 Cell Analyzer.
Anti Human CD25 Antibody, clone MEM-181 gallery image 23
Figure A. StarBright Violet 670 conjugated Mouse anti Human CD3 (MCA463SBV670). Figure B. StarBright Violet 670 conjugated Mouse anti Human CD3 (MCA463SBV670) and StarBright Blue 810 conjugated Mouse anti Human CD25 (MCA2127SBB810). All experiments performed on human PBMCs stimulated with PHA for 3 days gated on live lymphocytes, in the presence of 10% human serum. Data acquired on the ZE5 Cell Analyzer.
Anti Human CD25 Antibody, clone MEM-181 gallery image 24
Figure A. StarBright Blue 810 conjugated Mouse anti Human CD3 (MCA463SBB810). Figure B. StarBright Blue 810 conjugated Mouse anti Human CD3 (MCA463SBB810) and StarBright Yellow 575 conjugated Mouse anti Human CD25 (MCA2127SBY575). All experiments performed on human PBMCs stimulated with PHA for 3 days gated on live lymphocytes, in the presence of 10% human serum. Data acquired on the ZE5 Cell Analyzer.
Anti Human CD25 Antibody, clone MEM-181 gallery image 25
Figure A. StarBright Violet 610 conjugated Mouse anti Human CD3 (MCA463SBV610). Figure B. StarBright Violet 610 conjugated Mouse anti Human CD3 (MCA463SBV610) and StarBright Yellow 720 conjugated Mouse anti Human CD25 (MCA2127SBY720). All experiments performed on human PBMCs stimulated with PHA for 3 days gated on live lymphocytes, in the presence of 10% human serum. Data acquired on the ZE5 Cell Analyzer.
Anti Human CD25 Antibody, clone MEM-181 gallery image 26
Figure A. StarBright Blue 810 conjugated Mouse anti Human CD3 (MCA463SBB810). Figure B. StarBright Blue 810 conjugated Mouse anti Human CD3 (MCA463SBB810) and StarBright Yellow 605 conjugated Mouse anti Human CD25 (MCA2127SBY605). All experiments performed on human PBMCs stimulated with PHA for 3 days gated on live single cell lymphocytes, in the presence of 10% human serum. Data acquired on the ZE5 Cell Analyzer.

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Mouse anti Human CD25

Product Type
Monoclonal Antibody
Clone
MEM-181
Isotype
IgG1
Specificity
CD25

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MCA2127
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Mouse anti Human CD25, clone MEM-181 recognizes the ~55 kDa alpha subunit of the human IL-2 receptor, also known as p55 or TAC antigen, CD25 is a type 1 transmembrane protein with two Sushi domains, also known as short concensus repeats (SCRs) or complement control protein (CCP) modules (Norman et al. 1991) located within its extracellular domain.

The IL-2 receptor exists in three forms. A high affinity form consisting of a non-covalently linked heterodimer composed of the alpha subunit (CD25) and the IL-2 receptor beta subunit also known as CD122 or p75, a medium affinity beta subunit (CD122) monomer or a low affinity alpha (CD25) subunit monomer.

CD25 is expressed by activated T lymphocytes and activated B lymphocytes responding to antigen or mitogen stimulation. CD25 is also expressed in some thymocytes and oligodendrocytes. In disease, elevated expression of CD25 in noted in a number of chronic inflammatory conditions, tuberculoid leprosy patients demonstrate markedly elevated levels of circulating CD25high FoxP3+ regulatory T cells (T-regs) (Attia et al. 2010).

Elevated levels of CD25 antigen expression are often seen in cases of non-Hodgkin 's lymphoma and diffuse large B cell lymphoma (Fujiwara et al.2013).

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
0.09% sodium azide (NaN3)
Immunogen
Human PHA blasts; day 3 of culture.
Approx. Protein Concentrations
IgG concentration 1 mg/ml
Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse P3.X63 Ag8.653 myeloma cell line.
Regulatory
For research purposes only
Guarantee
12 months from date of despatch

This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.

Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry 1/50 1/200
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 10μl of the suggested working dilution to label 106 cells in 100μl

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References for CD25 antibody

  1. Prager, E. et al. (2001) Induction of hyporesponsiveness and impaired T lymphocyte activation by the CD31 receptor:ligand pathway in T cells.
    J Immunol. 166 (4): 2364-71.
  2. Thorborn, G. et al. (2010) Increased sensitivity of CD4+ T-effector cells to CD4+CD25+ Treg suppression compensates for reduced Treg number in asymptomatic HIV-1 infection.
    PLoS One. 5: e9254.
  3. Cutler, A.J. et al. (2010) Umbilical cord-derived mesenchymal stromal cells modulate monocyte function to suppress T cell proliferation.
    J Immunol. 185: 6617-23.
  4. Lawson, J.M. et al. (2008) Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes.
    Clin Exp Immunol. 154: 353-9.
  5. Holderness, J. et al. (2007) Select plant tannins induce IL-2Ralpha up-regulation and augment cell division in gammadelta T cells.
    J Immunol. 179: 6468-78.
  6. Zhang, Y. et al. (2013) Accelerated in vivo proliferation of memory phenotype CD4+ T-cells in human HIV-1 infection irrespective of viral chemokine co-receptor tropism.
    PLoS Pathog. 9 (4): e1003310.
  7. Nocentini, G. et al. (2014) Expansion of regulatory GITR + CD25 Low/- CD4 + T cells in systemic lupus erythematosus patients.
    Arthritis Res Ther. 16: 444.
  8. Soukup, K. et al. (2015) The MAPK-Activated Kinase MK2 Attenuates Dendritic Cell-Mediated Th1 Differentiation and Autoimmune Encephalomyelitis.
    J Immunol. 195 (2): 541-52.
    9. View The Latest Product References
  9. Kusunoki, Y. et al. (2010) T-cell immunosenescence and inflammatory response in atomic bomb survivors.
    Radiat Res. 174 (6): 870-6.
  10. Bughani, U. et al. (2017) T cell activation and differentiation is modulated by a CD6 domain 1 antibody Itolizumab.
    PLoS One. 12 (7): e0180088.
  11. Knutson, K.L. et al. (2015) Regulatory T cells, inherited variation, and clinical outcome in epithelial ovarian cancer.
    Cancer Immunol Immunother. 64 (12): 1495-504.
  12. Boland, J.W. et al. (2014) A preliminary evaluation of the effects of opioids on innate and adaptive human in vitro immune function.
    BMJ Support Palliat Care. 4 (4): 357-67.
  13. Luger, R. et al. (2013) Toll-like receptor 4 engagement drives differentiation of human and murine dendritic cells from a pro- into an anti-inflammatory mode.
    PLoS One. 8 (2): e54879.
  14. Rezalotfi, A. et al. (2020) Gastrospheres as a Model of Gastric Cancer Stem Cells Skew Th17/Treg Balance toward Antitumor Th17 Cells.
    J Immunol Res. 2020: 6261814.
  15. Thymianou, S et al. (2019) MBP7285 on Human Tcell Activation
    Mobile health Knoledge 21 Jul

Flow Cytometry

Immunofluorescence

Synonyms
IL-2R Alpha Chain
RRID
AB_324271
UniProt
P01589
Entrez Gene
IL2RA
GO Terms
GO:0016021 integral to membrane
GO:0004911 interleukin-2 receptor activity
GO:0008283 cell proliferation

MCA2127

1511 1608

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