CD175 antibody | BRIC111
Mouse anti Human CD175
- Product Type
- Monoclonal Antibody
|Mouse anti Human CD175 antibody, clone BRIC111 recognizes Tn antigen on glycophorin A and glycophorin B in human erythrocytes. Tn is a cryptantigen which was designated CD175 at the 7th Leucocyte Typing Workshop. Tn antigen is not expressed on normal haemopoietic cells but exposure of the Tn is associated with polyagglutination.|
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography from tissue culture supernatant
- Buffer Solution
- TRIS buffered glycine
- Preservative Stabilisers
- <0.1% sodium azide (NaN3)
- Human Tn red blood cells.
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml
- Fusion Partners
- Spleen cells from immunized mice were fused with cells of a myeloma cell line
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Immunohistology - Frozen|
- Histology Positive Control Tissue
- Human breast carcinoma
King, M.J. et al. (1991) Immunochemical studies on the differential binding properties of two monoclonal antibodies reacting with Tn red cells.
Transfusion 31 (2): 142-9.
References for CD175 antibody
King, M.J. et al. (1994) Two different glycosyltransferase defects that result in GalNAc alpha-O-peptide (Tn) expression.
Glycobiology. 4 (3): 267-79.
Wua, A.M. et al. (2005) Further characterization of the binding properties of two monoclonal antibodies recognizing human Tn red blood cells.
J Biomed Sci. 12 (1): 153-66.
Deutscher, S.L. et al. (2010) Carbohydrate antigens in nipple aspirate fluid predict the presence of atypia and cancer in women requiring diagnostic breast biopsy.
BMC Cancer. 10: 519.
(2008) Expression of CD175 (Tn), CD175s (sialosyl-Tn) and CD176 (Thomsen-Friedenreich antigen) on malignant human hematopoietic cells.
Int J Cancer. 123: 89-99.
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