CD140b antibody | PR7212
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Mouse anti Human CD140b
- Product Type
- Monoclonal Antibody
|Mouse anti Human CD140b antibody, clone PR7212 recognizes the extracellular domain of the human PDGF receptor beta subunit., confirmed using several different cell lines and by its ability to immunoprecipitate PDGF receptor beta complexed with 125I-PDGF-BB (Hart et al. 1987). Mouse anti Human CD140b antibody, clone PR7212 does not recognize PDGF receptor alpha.
PDGF receptor beta is a member of the class III receptor tyrosine kinase family that also includes M-CSF receptor, SCF receptor and Flt-3. Binding of PDGF-BB induces receptor homodimerization or heterodimerization with PDGF receptor alpha.
- Target Species
- Species Cross-Reactivity
Target Species Cross Reactivity Mouse Baboon Rat Monkey
- N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography on Protein G from ascites
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- <0.1% Sodium Azide (NaN3)
- Human skin fibroblast cell membrane extracts.
- Approx. Protein Concentrations
- 1.0 mg/ml
- For research purposes only
- 12 months from date of despatch
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
|Application Name||Verified||Min Dilution||Max Dilution|
|Flow Cytometry||25 �g/ml|
|Immunohistology - Frozen|
|Immunohistology - Paraffin||25 �g/ml|
- Histology Positive Control Tissue
- Human breast cancer tissue
Hart, C.E. et al. (1987) Synthesis, phosphorylation, and degradation of multiple forms of the platelet-derived growth factor receptor studied using a monoclonal antibody.
J Biol Chem. 262: 10780-5.
References for CD140b antibody
Hart, C.E. et al. (1988) Two classes of PDGF receptor recognize different isoforms of PDGF.
Science. 240: 1529-31.
Seifert, R.A. et al. (1989) Two different subunits associate to create isoform-specific platelet-derived growth factor receptors.
J Biol Chem. 264: 8771-8.
Franklin, W.A. et al. (1990) In situ distribution of the beta-subunit of platelet-derived growth factor receptor in nonneoplastic tissue and in soft tissue tumors.
Cancer Res. 50: 6344-8.
Krane, J.F. et al. (1991) Increased dermal expression of platelet-derived growth factor receptors in growth-activated skin wounds and psoriasis.
J Invest Dermatol. 96: 983-6.
Palman, C. et al. (1992) Platelet-derived growth factor receptor (beta-subunit) immunoreactivity in soft tissue tumors.
Lab Invest. 66: 108-15.
Wang, J. et al. (1994) Cell proliferation in human soft tissue tumors correlates with platelet-derived growth factor B chain expression: an immunohistochemical and in situ hybridization study.
Cancer Res. 54: 560-4.
Ascoli, V. et al. (1995) Platelet-derived growth factor receptor immunoreactivity in mesothelioma and nonneoplastic mesothelial cells in serous effusions.
Acta Cytol. 39: 613-22.
Gilbertson, D.G. et al. (2001) Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor.
J Biol Chem. 276: 27406-14.
View The Latest Product References
Meng, J. et al. (2011) Contribution of human muscle-derived cells to skeletal muscle regeneration in dystrophic host mice.
PLoS One. 6: e17454.
- PDGF Receptor Beta
- Entrez Gene
- GO Terms
- GO:0004992 platelet activating factor receptor activity
- GO:0005019 platelet-derived growth factor beta-receptor activity
- GO:0005021 vascular endothelial growth factor receptor activity
- GO:0005887 integral to plasma membrane
- GO:0005161 platelet-derived growth factor receptor binding
- GO:0005524 ATP binding
- GO:0008284 positive regulation of cell proliferation
- GO:0018108 peptidyl-tyrosine phosphorylation
- GO:0030335 positive regulation of cell migration
- View More GO Terms
- GO:0046777 protein autophosphorylation
- GO:0048407 platelet-derived growth factor binding
- GO:0060326 cell chemotaxis
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