CD140b antibody | PR7212



PDGF receptor beta is a member of the class III receptor tyrosine kinase family that also includes M-CSF receptor, SCF receptor and Flt-3. Binding of PDGF-BB induces receptor homodimerization or heterodimerization with PDGF receptor alpha.
Product Details
- Target Species
- Human
- Species Cross-Reactivity
-
Target Species Cross Reactivity Mouse Baboon Rat Monkey - N.B. Antibody reactivity and working conditions may vary between species.
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein G from ascites
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
0.09% Sodium Azide (NaN3) - Immunogen
- Human skin fibroblast cell membrane extracts.
- Approx. Protein Concentrations
- 1.0 mg/ml
Storage Information
- Storage
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P09619
- Entrez Gene
- PDGFRB
- GO Terms
- GO:0004992 platelet activating factor receptor activity
- GO:0005019 platelet-derived growth factor beta-receptor activity
- GO:0005021 vascular endothelial growth factor receptor activity
- GO:0005887 integral to plasma membrane
- GO:0005161 platelet-derived growth factor receptor binding
- GO:0005524 ATP binding
- GO:0008284 positive regulation of cell proliferation
- GO:0018108 peptidyl-tyrosine phosphorylation
- GO:0030335 positive regulation of cell migration
- GO:0046777 protein autophosphorylation
- GO:0048407 platelet-derived growth factor binding
- GO:0060326 cell chemotaxis
- Regulatory
- For research purposes only
Applications of CD140b antibody
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Flow Cytometry | 25 �g/ml | ||
Immunofluorescence | |||
Immunohistology - Frozen | |||
Immunohistology - Paraffin | 25 �g/ml | ||
Immunoprecipitation | |||
Western Blotting |
- Histology Positive Control Tissue
- Human breast cancer tissue
Secondary Antibodies Available
Negative Isotype Controls Available
Description | Product Code | Applications | Pack Size | List Price | Quantity |
---|---|---|---|---|---|
Mouse IgG1 Negative Control | MCA928 | F | 100 Tests |
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Product Specific References
References for CD140b antibody
-
Hart, C.E. et al. (1987) Synthesis, phosphorylation, and degradation of multiple forms of the platelet-derived growth factor receptor studied using a monoclonal antibody.
J Biol Chem. 262: 10780-5. -
Hart, C.E. et al. (1988) Two classes of PDGF receptor recognize different isoforms of PDGF.
Science. 240: 1529-31. -
Franklin, W.A. et al. (1990) In situ distribution of the beta-subunit of platelet-derived growth factor receptor in nonneoplastic tissue and in soft tissue tumors.
Cancer Res. 50: 6344-8. -
Seifert, R.A. et al. (1989) Two different subunits associate to create isoform-specific platelet-derived growth factor receptors.
J Biol Chem. 264: 8771-8. -
Krane, J.F. et al. (1991) Increased dermal expression of platelet-derived growth factor receptors in growth-activated skin wounds and psoriasis.
J Invest Dermatol. 96: 983-6. -
Palman, C. et al. (1992) Platelet-derived growth factor receptor (beta-subunit) immunoreactivity in soft tissue tumors.
Lab Invest. 66: 108-15. -
Ascoli, V. et al. (1995) Platelet-derived growth factor receptor immunoreactivity in mesothelioma and nonneoplastic mesothelial cells in serous effusions.
Acta Cytol. 39: 613-22. -
Gilbertson, D.G. et al. (2001) Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor.
J Biol Chem. 276: 27406-14. -
Wang, J. et al. (1994) Cell proliferation in human soft tissue tumors correlates with platelet-derived growth factor B chain expression: an immunohistochemical and in situ hybridization study.
Cancer Res. 54: 560-4. -
Meng, J. et al. (2011) Contribution of human muscle-derived cells to skeletal muscle regeneration in dystrophic host mice.
PLoS One. 6: e17454.
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