CD122 antibody | TU27
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Mouse anti Human CD122
- Product Type
- Monoclonal Antibody
- Clone
- TU27
- Isotype
- IgG1
- Specificity
- CD122
Antibody Quality and Performance Guarantee
| Mouse anti Human CD122 recognizes CD122 also known as IL-2 receptor beta chain. CD122 is a 70-75 kDa transmembrane protein and member of of the Ig superfamily. CD122 is primarily expressed by NK cells and but also by certain subsets of T cells. CD122 dimerises with either CD132 or CD25 to form IL-2 receptors. Activation of the IL-2 receptor induces signaling within MAPK, PI3K and JAK-STAT pathways. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Immunogen
- TL-Mor cell line.
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
- Fusion Partners
- Spleen cells from immunized Balb/c mice were fused with cells from the murine SP2/0-Ag14 non-secreting myeloma.
- Regulatory
- For research purposes only
- Guarantee
- Guaranteed for 12 months from the date of despatch or until the date of expiry, whichever comes first. Please see label for expiry date.
Store at +4oC. DO NOT FREEZE.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| Flow Cytometry |  |
1/10 | 1/40 |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
- Flow Cytometry
- Use 10 μl of the suggested working dilution to label 1x106 cells in 100ul
| Description | Product Code | Applications | Pack Size | List Price | Your Price | Quantity | |
|---|---|---|---|---|---|---|---|
| Mouse IgG1 Negative Control | MCA928 | F | 100 Tests |
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| List Price | Your Price | ||||||
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| Description | Mouse IgG1 Negative Control | ||||||
Source Reference
-
Takeshita, T. et al. (1989) Monoclonal antibody defining a molecule possibly identical to the p75 subunit of interleukin 2 receptor.
J Exp Med. 169 (4): 1323-32.
References for CD122 antibody
-
Phillips, J.H. et al. (1989) Activation of natural killer cells via the p75 interleukin 2 receptor.
J Exp Med. 170 (1): 291-6. -
Yagita, H. et al. (1989) Activation of peripheral blood T cells via the p75 interleukin 2 receptor.
J Exp Med. 170 (4): 1445-50. -
Suzuki, J. et al. (1989) IL-2 receptor subunit, p75: direct demonstration of its IL-2 binding ability by using a novel monoclonal antibody.
Int Immunol. 1 (4): 373-7. -
Espinoza-delgado, I. et al. (1990) Expression and role of p75 interleukin 2 receptor on human monocytes.
J Exp Med. 171 (5): 1821-6. -
Starkey, P.M. (1991) Expression on cells of early human pregnancy decidua, of the p75, IL-2 and p145, IL-4 receptor proteins.
Immunology. 73 (1): 64-70. -
Trentin, L. et al. (1992) Expression and functional role of the p75 interleukin 2 receptor chain on leukemic hairy cells.
Cancer Res. 52 (19): 5223-8.
- UniProt
- P14784
- Entrez Gene
- IL2RB
- GO Terms
- GO:0004911 interleukin-2 receptor activity
- GO:0005887 integral to plasma membrane
- GO:0006461 protein complex assembly
- GO:0009897 external side of plasma membrane
- GO:0044419 interspecies interaction between organisms
- GO:0045885 positive regulation of survival gene product expression
MCA6060GA
151938
166799
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