Mouse anti human CD121a, clone 35730,
recognizes interleukin-1 receptor type 1 (IL1R1). IL1RA/CD121a is widely expressed in a number of cell types including T cells and fibroblasts (Sims et al.
)and is involved in the activation of NF-kappa-B (Slack et al.
- Target Species
- Product Form
- Purified IgG - liquid
- Purified IgG prepared by affinity chromatography from ascites
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- 0.09% Sodium Azide (NaN3)
- Recombinant peptide corresponding to the extracellular domain of human CD121a expressed in insect cell line Sf21.
- Approx. Protein Concentrations
- IgG concentration 0.5 mg/ml
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
- 18 months from date of despatch.
- Entrez Gene
- GO Terms
interleukin-1, Type I, activating receptor activity
integral to plasma membrane
platelet-derived growth factor receptor binding
innate immune response
interleukin-1-mediated signaling pathway
response to interleukin-1
- For research purposes only
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Applications of CD121a antibody
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.
Copyright © 2020 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
Product Specific References
Sims, J. et al. (1989) Cloning the interleukin 1 receptor from human T cells.
Proc Natl Acad Sci U S A. 86: 8946-50.
Slack, J. et al. (2000) Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways.
J Biol Chem. 275:4670-8.