CD11c antibody | CBR-p150/4G1

CD11c combines with the CD18 beta chain (ITGB2) to form the leukocyte specific integrin CR4, acts as a mediator of leukocyte adherence to endothelium, and binds to the ligands CD54 (ICAM1), iC3b and fibrinogen.
Mouse anti Human CD11c antibody, clone CBR-p150/4G1 inhibits the binding of CD11c to endothelial cells. Mouse anti Human CD11c antibody, clone CBR-p150/4G1 does not recognize CD11a, CD11b or CD18.
Product Details
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Immunogen
- Recombinant human CD11c.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
Storage Information
- Storage
- Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P20702
- Entrez Gene
- ITGAX
- GO Terms
- GO:0005515 protein binding
- GO:0007596 blood coagulation
- GO:0007155 cell adhesion
- GO:0004872 receptor activity
- GO:0008305 integrin complex
- GO:0007229 integrin-mediated signaling pathway
- GO:0009887 organ morphogenesis
- GO:0050900 leukocyte migration
- Regulatory
- For research purposes only
Applications of CD11c antibody
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
Flow Cytometry | |||
Functional Assays | |||
Immunohistology - Frozen | 5 | 10ug/ml |
- Flow Cytometry
- Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
Secondary Antibodies Available
Negative Isotype Controls Available
Description | Product Code | Applications | Pack Size | List Price | Quantity |
---|---|---|---|---|---|
Mouse IgG2a Negative Control | MCA929 | F | 100 Tests |
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Product Specific References
References for CD11c antibody
-
Schack, L. et al. (2009) Osteopontin enhances phagocytosis through a novel osteopontin receptor, the alphaXbeta2 integrin.
J Immunol. 182: 6943-50.
Further Reading
-
Corbi, A.L. et al. (1990) Genomic structure of an integrin alpha subunit, the leukocyte p150,95 molecule.
J Biol Chem. 265 (5): 2782-8.
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