CD11c antibody | CBR-p150/4G1

Mouse anti Human CD11c:Preservative Free

Product Type
Monoclonal Antibody
Clone
CBR-p150/4G1
Isotype
IgG2a
Specificity
CD11c

Product Code Applications Pack Size List Price Your Price Qty
MCA2786Z
Datasheet Datasheet Datasheet
SDS Safety Datasheet SDS
C F FN 0.1 mg loader
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loader
Search for Batch Specific Datasheets

Mouse anti Human CD11c antibody, clone CBR-p150/4G1 specifically recognizes human CD11c, otherwise known as integrin alpha X chain and leukocyte adhesion receptor p150,95, a ~150 kDa type I transmembrane protein and member of the integrin alpha chain family, expressed by monocytes, macrophages, granulocytes and NK cells, and is a marker for hairy cell leukaemia cells.

CD11c combines with the CD18 beta chain (ITGB2) to form the leukocyte specific integrin CR4, acts as a mediator of leukocyte adherence to endothelium, and binds to the ligands CD54 (ICAM1), iC3b and fibrinogen.

Mouse anti Human CD11c antibody, clone CBR-p150/4G1 inhibits the binding of CD11c to endothelial cells. Mouse anti Human CD11c antibody, clone CBR-p150/4G1 does not recognize CD11a, CD11b or CD18.

Target Species
Human
Product Form
Purified IgG - liquid
Preparation
Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution
Phosphate buffered saline
Preservative Stabilisers
None present
Immunogen
Recombinant human CD11c.
Approx. Protein Concentrations
IgG concentration 1.0mg/ml
Regulatory
For research purposes only
Guarantee
Guaranteed for 12 months from the date of despatch or until the date of expiry, whichever comes first. Please see label for expiry date.

Store at -20oC only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
Application Name Verified Min Dilution Max Dilution
Flow Cytometry
Functional Assays
Immunohistology - Frozen 5 10ug/ml
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Flow Cytometry
Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.

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References for CD11c antibody

  1. Schack, L. et al. (2009) Osteopontin enhances phagocytosis through a novel osteopontin receptor, the alphaXbeta2 integrin.
    J Immunol. 182: 6943-50.

Further Reading

  1. Corbi, A.L. et al. (1990) Genomic structure of an integrin alpha subunit, the leukocyte p150,95 molecule.
    J Biol Chem. 265 (5): 2782-8.

Synonyms
Integrin Alpha X Chain
RRID
AB_1100627
UniProt
P20702
Entrez Gene
ITGAX
GO Terms
GO:0005515 protein binding
GO:0007596 blood coagulation
GO:0007155 cell adhesion
GO:0004872 receptor activity
GO:0008305 integrin complex
GO:0007229 integrin-mediated signaling pathway
GO:0009887 organ morphogenesis
GO:0050900 leukocyte migration
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Please Note: All Products are "FOR RESEARCH PURPOSES ONLY"

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