CCL11 antibody | 1.3_17H09-02C06

CCL11 acts as a chemoattractant for eosinophil recruitment to inflammatory sites, including during asthma attacks (Wen & Rothenberg 2016). Upon binding of CCL11 to its receptor CCR3, a series of signaling events are triggered which can result in calcium mobilization, CD11b upregulation, MAPK activation and actin polymerization. It can also result in a rapid change of shape associated with chemotaxis and granule release (Conroy & Williams 2001).
Product Details
- Target Species
- Human
- Product Form
- Purified IgG - lyophilized
- Reconstitution
- Reconstitute with 0.5 ml distilled water
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
- Buffer Solution
- Phosphate buffered saline
- Preservative Stabilisers
- None present
- Carrier Free
- Yes
- Immunogen
- E. coli derived recombinant human CCL11
- Approx. Protein Concentrations
- IgG concentration 1.0 mg/ml after reconstitution
- Endotoxin Level
- < 1 EU/μg
Storage Information
- Storage
- Prior to reconstitution store at -20°C.
After reconstitution store at -20°C.
This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- 12 months from date of despatch
More Information
- UniProt
- P51671
- Entrez Gene
- CCL11
- GO Terms
- GO:0001938 positive regulation of endothelial cell proliferation
- GO:0009615 response to virus
- GO:0007155 cell adhesion
- GO:0007165 signal transduction
- GO:0005615 extracellular space
- GO:0006468 protein phosphorylation
- GO:0006874 cellular calcium ion homeostasis
- GO:0006935 chemotaxis
- GO:0006954 inflammatory response
- GO:0006955 immune response
- GO:0008009 chemokine activity
- GO:0009314 response to radiation
- GO:0030335 positive regulation of cell migration
- GO:0030838 positive regulation of actin filament polymerization
- GO:0032855 positive regulation of Rac GTPase activity
- Regulatory
- For research purposes only
Applications of CCL11 antibody
Application Name | Verified | Min Dilution | Max Dilution |
---|---|---|---|
ELISA | 2.0 ug/ml | 1.0 ug/ml | |
Western Blotting | 0.25 ug/ml | 0.5 ug/ml |
Secondary Antibodies Available
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