C9 antibody | 002-94.8.8
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Mouse anti Human C9 antibody, clone 002-94.8.8 recognises complement component 9 (C9), a 71 kDa member of the complement C6/C7/C8/C9 family present in the blood serum and synthesised by the liver and monocytes. C9 is the last component to be added during the formation of the membrane attack complex (MAC), binding the membrane associated C5b-8 complex and resulting in the circular polymerisation of 12-18 C9 molecules. This forms the hydrophilic transmembrane channel which causes cell lysis. Deficiency of C9 is associated with recurring infections by Neisseria meningitides.
Mouse anti Human C9 antibody, clone 002-94.8.8 does not recognise MAC.
Mouse anti Human C9 antibody, clone 002-94.8.8 does not recognise MAC.
Product Details
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A
- Buffer Solution
- Borate buffered saline
- Preservative Stabilisers
0.1% Sodium Azide (NaN3) - Immunogen
- Purified human C9.
- Approx. Protein Concentrations
- IgG concentration 1.0mg/ml
Storage Information
- Storage
- Store at +4oC or at -20oC if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. - Guarantee
- Guaranteed until date of expiry. Please see product label.
More Information
- UniProt
- P02748 Related reagents
- Entrez Gene
- C9 Related reagents
- GO Terms
- GO:0005576 extracellular region
- GO:0005579 membrane attack complex
- GO:0006957 complement activation, alternative pathway
- GO:0006958 complement activation, classical pathway
- GO:0019835 cytolysis
- GO:0019836 hemolysis by symbiont of host erythrocytes
- Regulatory
- For research purposes only
Applications of C9 antibody
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Copyright © 2019 Bio-Rad Antibodies (formerly AbD Serotec)
Secondary Antibodies Available
Product Specific References
References for C9 antibody
-
Huang, Y. et al. (2006) Defining the CD59-C9 binding interaction.
J Biol Chem. 281 (37): 27398-404.
