C9 antibody | 002-94.8.8
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Mouse anti Human C9
- Product Type
- Monoclonal Antibody
- Clone
- 002-94.8.8
- Isotype
- IgG2b
- Specificity
- C9
Antibody Quality and 
Unrivaled 
| Mouse anti Human C9 antibody, clone 002-94.8.8 recognises complement component 9 (C9), a 71 kDa member of the complement C6/C7/C8/C9 family present in the blood serum and synthesised by the liver and monocytes. C9 is the last component to be added during the formation of the membrane attack complex (MAC), binding the membrane associated C5b-8 complex and resulting in the circular polymerisation of 12-18 C9 molecules. This forms the hydrophilic transmembrane channel which causes cell lysis. Deficiency of C9 is associated with recurring infections by Neisseria meningitides. Mouse anti Human C9 antibody, clone 002-94.8.8 does not recognise MAC. |
- Target Species
- Human
- Product Form
- Purified IgG - liquid
- Preparation
- Purified IgG prepared by affinity chromatography on Protein A from ascites
- Buffer Solution
- Borate buffered saline
- Preservative Stabilisers
0.1% Sodium Azide (NaN3) - Immunogen
- Purified human C9.
- Approx. Protein Concentrations
- IgG concentration 1.01 mg/ml
- Regulatory
- For research purposes only
- Guarantee
- Guaranteed until date of expiry. Please see product label.
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit the antibody protocols page.
| Application Name | Verified | Min Dilution | Max Dilution |
|---|---|---|---|
| ELISA |  |
Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
References for C9 antibody
-
Huang, Y. et al. (2006) Defining the CD59-C9 binding interaction.
J Biol Chem. 281 (37): 27398-404.
- Synonyms
- Complement Component 9
- RRID
- AB_2228271
- UniProt
- P02748
- Entrez Gene
- C9
- GO Terms
- GO:0005576 extracellular region
- GO:0005579 membrane attack complex
- GO:0006957 complement activation, alternative pathway
- GO:0006958 complement activation, classical pathway
- GO:0019835 cytolysis
- GO:0019836 hemolysis by symbiont of host erythrocytes
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